Modulation Agents of Wound Healing in Ocular Surgeries
https://doi.org/10.47836/mjmhs.20.1.37
- Author:
Yaakub Azhany
1
;
Mohd-Yusof Siti-Fairuz
2
;
Azlina Ahmad
3
;
Wan Nazirah Wan Yusuf
4
;
Low Jen Hou
4
;
Ahmad-Tajudin Liza-Sharmini
2
;
Jemaima Che Hamzah
5
Author Information
1. Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia&Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
2. Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
3. Biochemistry/Molecular Biology, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Malaysia
4. Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
5. Department of Ophthalmology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia&
- Publication Type:Review
- Keywords:
Modulation agent, wound healing, ocular surgeries, trabeculectomy
- From:Malaysian Journal of Medicine and Health Sciences
2024;20(No.1):293-303
- CountryMalaysia
- Language:English
-
Abstract:
Wound healing is a complex process that includes haemostasis and inflammation, followed by a proliferation period and repair and finally remodelling. Ocular surgeries, particularly in glaucoma cases, aim at minimal fibrosis to preserve the function of trabeculectomy as an alternative pathway for aqueous drainage. Hence, it is important to find an agent to modulate the wound healing process. This review presents compilation of wound modulation agents that have been tested in vitro, in vivo, or clinically on patients undergoing ocular surgeries, particularly for glaucoma. We identified agents into four groups, mostly for glaucoma filtration operations: anti-metabolites, anti-growth factors, mechanical barriers and rho kinases. The effect of these agents is highlighted in this review. In conclusion,
despite recognized drawbacks of antimetabolites, they are still regarded as the gold standard and the most efficient treatment as anti-scarring agents use in ocular surgeries. More studies are needed to inquire agents that efficient yet has minimal adverse effects both in short and long term.
- Full text:11.2024my1741.pdf
