Research progress of traditional Chinese medicine monomer and compound intervention on the Wnt signaling pathway in regulating bone metabolism
- VernacularTitle:中药单体及复方干预Wnt信号通路调控骨代谢的研究进展
- Author:
Ting LI
1
;
Xiaoqiong ZHANG
2
;
Mei LIU
2
;
Qin WANG
1
Author Information
1. College of Pharmacy，Chongqing Medical University，Chongqing 400016，China
2. Dept. of Pharmacy，the First Affiliated Hospital of Chongqing College of Traditional Chinese Medicine/Chongqing Traditional Chinese Medicine Hospital，Chongqing 400021，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine monomer;
traditional Chinese medicine compound;
bone metabolism;
Wnt signaling
- From:
China Pharmacy
2024;35(5):623-628
- CountryChina
- Language:Chinese
-
Abstract:
Bone metabolism refers to the decomposition and anabolism occurring during bone remodeling， and its balance is regulated by bone resorption and bone formation. A slight deviation of this balance causes various skeletal diseases， such as osteoporosis and renal osteodystrophy. Traditional Chinese medicine （TCM） monomers and compounds have certain advantages in treating bone metabolism diseases. The Wnt signaling pathway includes the canonical Wnt signaling pathway， dependent on β-catenin， and the non-canonical Wnt signaling pathway， independent of β-catenin. Both types of pathways can maintain bone metabolism balance by regulating bone formation and bone resorption and are essential for bone development， bone mass maintenance， and bone remodeling. A variety of TCM monomers （albiflorin， catalpol and icariin） and formulas （Zuogui pill， Yishen gugu prescription， Duzhong jiangu prescription， etc.） have been confirmed to promote differentiation of bone marrow mesenchymal stem cells， proliferation and differentiation of osteoblasts， bone injury repair， and osteoporosis improvement by activating the Wnt signaling pathway in recent years. Here， this article summarizes the research progress in the Wnt signaling pathway regulation of bone metabolism by TCM monomers and compounds to provide ideas for the clinical application of TCM and the research and development of new drugs for the prevention and treatment of bone metabolism diseases.
