Application of a polygenic risk score in the early prediction of myopia in children and adolescents
10.16835/j.cnki.1000-9817.2024012
- VernacularTitle:多基因风险评分在儿童青少年近视早期预测研究中的应用
- Author:
GAO Zhenshan, TAO Fangbiao
1
Author Information
1. Department of Maternal, Child & Adolescent Health, School of Public Health, Anhui Medical University, Hefei (230032) , Anhui Province, China
- Publication Type:Journal Article
- Keywords:
Genes;
Myopia;
Models,statistical;
Child;
Adolescent
- From:
Chinese Journal of School Health
2024;45(1):148-152
- CountryChina
- Language:Chinese
-
Abstract:
Abstract:Myopia has become a major public health issue of global concern. Scientific and effective myopia prediction models can help identify high risk groups for myopia, thereby achieving precise prevention. With the rapid development of genome wide association studies and the establishment of large scale prospective population cohorts, the polygenic risk score (PRS) model has been used to predict myopia phenotypes, advancing the myopia prediction window and thus predicting high myopia risk for early screening and intervention for at risk groups. The review aims to systematically elaborate the identification and verification of myopia genes in recent years, briefly describe the practice and effectiveness evaluation of the PRS model in myopia prevention research at home and abroad, reveal the application value in myopia prediction research, and emphasize the relationship between the PRS prediction model and outdoor activities. Close eye use and other preventive measures are of great significance to promote the precise prevention of myopia in children and adolescents.
