Research progress of microRNA in choroidal neovascularization signaling pathway
10.3980/j.issn.1672-5123.2024.3.06
- VernacularTitle:微小RNA在脉络膜新生血管相关信号通路中的研究进展
- Author:
Lingqi YANG
1
;
Yang LYU
1
Author Information
1. First School of Clinical Medical, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China; Ophthalmic Center; Laboratory of Stem Cell and Gene Medicine of Gansu Province, the 940th Hospital of Joint Service Support Forces of the Chinese People's Liberation Army, Lanzhou 730050, Gansu Province, China
- Publication Type:Journal Article
- Keywords:
choroidal neovascularization;
microRNA;
signaling pathway;
vascular endothelial growth factor;
bone marrow-derived cell
- From:
International Eye Science
2024;24(3):362-367
- CountryChina
- Language:Chinese
-
Abstract:
Choroidal neovascularization(CNV)is the ultimate pathological manifestation of various ocular diseases. Its pathogenesis is extremely complex and involves multiple cells, cytokines, and signaling pathways. MicroRNA(miRNA), as a kind of small biological molecules, is a non-coding RNA composed of 22 nucleotides that regulates gene expression by degrading or inhibiting mRNA translation of target genes. Having been increasingly studied and their involvement in the development of various diseases through miRNA-mediated signaling pathways have been revealed. In the field of ophthalmology, miRNA target specific protein genes through various signaling pathways to promote or inhibit CNV. Therefore, revealing the role and mechanism of miRNA in the pathogenesis of CNV is an important direction of future research on the pathogenesis of CNV. This article aims to review on phosphatidylinositol 3 kinase- protein kinase B(PI3K-Akt), transforming growth factor-beta(TGF-β), nuclear factor-kappa B(NF-κB), Notch and Wnt signaling pathways in miRNA regulation of CNV, providing new insights into the pathogenesis of CNV and targeted therapy for CNV.
