Advances in low-frequency ultrasound combined with microbubbles in targeted tumor therapy.

Li-Ying WANG; Shu-Sen ZHENG

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Advances in low-frequency ultrasound combined with microbubbles in targeted tumor therapy.

Author: Li-Ying WANG ¹ ; Shu-Sen ZHENG ²
Author Information

1. Department of Ultrasound, Shaoxing Second Hospital, Shaoxing 312000, China.
2. Key Laboratory of Combined Multi-organ Transplantation, Ministry of Health, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Publication Type:Review
Keywords: Low-frequency ultrasound; Microbubble; Gene; Drug; Cell death
MeSH: Antineoplastic Agents/therapeutic use*; Apoptosis; Autophagy; Cell Membrane Permeability; Cell Proliferation; Contrast Media/administration & dosage*; Drug Delivery Systems; Humans; Microbubbles; Microcirculation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms/therapy*; Patient Safety; Transfection; Ultrasonic Therapy/methods*
From: Journal of Zhejiang University. Science. B 2019;20(4):291-299
CountryChina
Language:English
Abstract: The development of low-frequency ultrasound imaging technology and the improvement of ultrasound contrast agent production technology mean that they play an increasingly important role in tumor therapy. The interaction between ultrasound and microbubbles and their biological effects can transfer and release microbubbles carrying genes and drugs to target tissues, mediate the apoptosis of tumor cells, and block the embolization of tumor microvasculature. With the optimization of ultrasound parameters, the development of targeted microbubbles, and the emergence of various composite probes with both diagnostic and therapeutic functions, low-frequency ultrasound combined with microbubble contrast agents will bring new hope for clinical tumor treatment.