Dopamine receptor D2 polymorphism is associated with alleviation of obesity after 8-year follow-up: a retrospective cohort study in obese Chinese children and adolescents.
- Author:
Jian-Fang ZHU
1
;
Lian-Hui CHEN
2
;
Ke YUAN
1
;
Li LIANG
1
;
Chun-Lin WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Obesity; Follow-up study; Dopamine receptor D2; Children; Adolescent
- MeSH: Adolescent; Body Mass Index; Child; Female; Humans; Male; Obesity/genetics*; Polymorphism, Single Nucleotide; Receptors, Dopamine D2/genetics*; Retrospective Studies
- From: Journal of Zhejiang University. Science. B 2018;19(10):807-814
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:The aim of this study was to explore the association of dopamine receptor D2 (DRD2) polymorphism and alleviation of obesity in children and adolescents after 8-year follow-up.
METHODS:This retrospective cohort study included obese children and adolescents with a follow-up period of 8 years. Baseline clinical characteristics and DRD2 polymorphisms (including rs1076562, rs2075654, and rs4586205) were extracted from medical records. A follow-up visit was performed in May 2017 to collect related data including height, weight, diet compliance, and exercise compliance.
RESULTS:One hundred and nine obese children and adolescents were included in the current study. Among three DRD2 single nucleotide polymorphisms, only rs2075654 had a statistically significant association with alleviation of obesity, as the alleviation rate for minor allele carriers (68.6% for TC+TT) was higher compared to the major allele homozygote (43.3% for CC). After adjusting for all related factors, the hazard ratio of rs2075654 minor allele carriers for the alleviation of obesity was 3.34 (95% confidence interval (CI): 1.30‒8.58).
CONCLUSIONS:The rs2075654 polymorphism of DRD2 is related to long-term obesity alleviation in obese Chinese children and adolescents.
