The Prognostic Value of Prognostic Nutritional Index Combined with D-dimer in Patients with Diffuse Large B-Cell Lymphoma.
10.19746/j.cnki.issn.1009-2137.2023.05.021
- Author:
Ye HAN
1
;
Ying SONG
1
;
Yin WANG
1
;
Qi-Qi JIN
1
;
Hao-Yun JIANG
1
;
Ye CHAI
1
;
Peng-Yun ZENG
1
;
Ling-Ling YUE
1
;
Chong-Yang WU
2
Author Information
1. Department of Hematology, The Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China.
2. Department of Hematology, The Second Hospital of Lanzhou University, Lanzhou 730030, Gansu Province, China E-mail: wuchy@lzu.edu.cn.
- Publication Type:Journal Article
- Keywords:
D-dimer;
diffuse large B-cell lymphoma;
prognosis;
prognostic nutritional index
- MeSH:
Humans;
Prognosis;
Nutrition Assessment;
Retrospective Studies;
Lymphoma, Large B-Cell, Diffuse/pathology*
- From:
Journal of Experimental Hematology
2023;31(5):1385-1393
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the effects of prognostic nutritional index (PNI) combined with D-dimer on the prognosis of patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL).
METHODS:The clinical data of 73 DLBCL patients at initial diagnosis were retrospectively evaluated, and the optimal cut-off point of PNI and D-dimer were determined by ROC curve. The overall survival (OS) rate and progression-free survival (PFS) rate in different subgroups were compared using Kaplan-Meier survival curves. Univariate and multivariate Cox regression analysis was performed to identify the factors associated with OS.
RESULTS:Compared with the low PNI group (PNI<44.775), the high PNI group (PNI≥44.775) had better OS (P =0.022) and PFS (P =0.029), the 2-year OS rates of the two groups were 55.6% and 78.3% respectively (P =0.041). Compared with the high D-dimer group (D-dimer≥0.835), the low D-dimer group (D-dimer<0.835) had better OS (P <0.001) and PFS (P <0.001), the 2-year OS rates of the two groups were 51.4% and 86.8% respectively (P =0.001). Meanwhile, patients in the high PNI+ low D-dimer group had better OS (P =0.003) and PFS (P <0.001) than the other three groups, the 2-year OS rate was statistically different from the other three groups (P <0.05). The multivariate analysis revealed that NCCN-IPI (HR =2.083, 95%CI : 1.034-4.196, P =0.040), PNI (HR =0.267, 95%CI : 0.076-0.940, P =0.040) and PNI+D-dimer (HR =9.082, 95%CI : 1.329-62.079, P =0.024) were the independent risk factors affecting OS in patients with DLBCL. Subgroup analysis showed that PNI, D-dimer, and PNI combined with D-dimer could improve the prognostic stratification in low and low-intermediate risk DLBCL patients.
CONCLUSION:High PNI, low D-dimer and combination of high PNI and low D-dimer at initial diagnosis suggest a better prognosis in DLBCL patients.
