Prognostic role of chromogranin A in castration-resistant prostate cancer: A meta-analysis.
- Author:
Peng HONG
1
;
Run-Qi GUO
1
;
Gang SONG
1
;
Kai-Wei YANG
1
;
Lei ZHANG
1
;
Xue-Song LI
1
;
Kai ZHANG
1
;
Li-Qun ZHOU
1
Author Information
- Publication Type:Review
- Keywords: castration-resistant prostate cancer; chromogranin A; prognosis
- MeSH: Chromogranin A/analysis*; Humans; Male; Predictive Value of Tests; Prognosis; Prostatic Neoplasms, Castration-Resistant/diagnosis*; Reproducibility of Results; Survival Analysis
- From: Asian Journal of Andrology 2018;20(6):561-566
- CountryChina
- Language:English
- Abstract: We aimed to investigate the prognostic value of chromogranin A (CgA) in castration-resistant prostate cancer (CRPC). We conducted a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to September 2017 that described CgA and CRPC and performed a standard meta-analysis on survival outcomes. Our meta-analysis included eight eligible studies with 686 patients. The results were as follows: progression-free survival (PFS) was associated with CgA level (hazard ratio [HR] = 2.47, 95% confidence interval [CI]: 1.47-4.14, P = 0.0006); PFS was relative to CgA change (HR = 9.22, 95% CI: 3.03-28.05, P < 0.0001); and overall survival (OS) was relative to CgA level (HR = 1.47, 95% CI: 1.15-1.87, P = 0.002). When we divided the patients into two groups according to therapy status, the result for OS relative to CgA level was an HR of 1.26 (95% CI: 1.09-1.45, P = 0.001) in the first-line hormonal therapy group, and an HR of 2.33 (95% CI: 1.40-3.89, P = 0.001) in the second-line hormonal therapy or chemotherapy group. This meta-analysis indicated that a high CgA level had a negative influence on OS and PFS in CRPC patients. In addition, CRPC patients with a rising CgA had a shorter PFS. Further studies are needed to verify the prognostic value of CgA in CRPC.
