Research progress on structure, structure-activity relationship, and biological activity of Aconiti Lateralis Radix Praeparata polysaccharides.
10.19540/j.cnki.cjcmm.20230516.301
- Author:
Jun TANG
1
;
Xin YANG
1
;
Xin YANG
1
;
Qi HU
1
;
Ji-Hai GAO
1
;
Ming YANG
2
;
Ya-Nan HE
1
;
Ding-Kun ZHANG
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
2. Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
Aconiti Lateralis Radix Praeparata polysaccharides;
biological activity;
polysaccharide structure;
process;
structure-activity relationship
- MeSH:
Drugs, Chinese Herbal/chemistry*;
Aconitum/chemistry*;
Polysaccharides/pharmacology*;
Structure-Activity Relationship;
Technology
- From:
China Journal of Chinese Materia Medica
2023;48(20):5410-5418
- CountryChina
- Language:Chinese
-
Abstract:
Aconiti Lateralis Radix Praeparata polysaccharides(AP) are a class of bioactive macromolecules extracted from the herbs of Aconiti Lateralis Radix Praeparata and its various processed products. Since the AP was first separated in 1986, its pharmacological effects include immune regulation, anti-tumor, anti-depression, organ protection, hypoglycemia, and anti-inflammatory had been found. In recent years, with the development of polysaccharide extraction, separation, and structure identification technologies, more than 20 kinds of AP have been separated from Aconiti Lateralis Radix Praeparata and its processed products, and they have ob-vious differences in relative molecular weight, monosaccharide composition, glycosidic bond, structural characteristics, and biological activities. In particular, AP may be dissolved, degraded, or allosteric under the complex processing environment of fermentation, soaking, cooking, etc., leading to the diversified structure of AP, which provides a possibility for further understanding of the structure-activity relationship of AP. Therefore, this study systematically reviewed the research progress on the structure and structure-activity relationship of AP, summarized the biological activity and potential action mechanism of AP, and discussed the technical challenges in the development and application of AP, so as to promote the quality control and further development and utilization of AP.
