Untargeted metabonomics study of ginseng in treatment of spleen-Qi deficiency.
10.19540/j.cnki.cjcmm.20191017.201
- Author:
Ni WANG
1
;
Na ZHANG
1
;
Tie LI
2
;
Mei WANG
3
;
Xin HUANG
1
;
Shu-Ying LIU
1
Author Information
1. Jilin Ginseng Academy, Changchun University of Chinese Medicine Changchun 130117, China.
2. Acupuncture Massage School, Changchun University of Chinese Medicine Changchun 130117, China.
3. LU-European Center for Chinese Medicine and Natural Compounds, Leiden University Sylviusweg 72,2333BE, Netherlands.
- Publication Type:Journal Article
- Keywords:
RRLC-Q-TOF-MS;
ginseng;
spleen-Qi deficiency;
untargeted metabonomics
- MeSH:
Antioxidants;
Biomarkers/blood*;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal/therapeutic use*;
Energy Metabolism;
Humans;
Immune System;
Medicine, Chinese Traditional;
Metabolomics;
Panax/chemistry*;
Qi;
Spleen
- From:
China Journal of Chinese Materia Medica
2020;45(2):398-404
- CountryChina
- Language:Chinese
-
Abstract:
Ginseng has been used to treat Qi-deficiency syndrome up to now, while the therapeutic mechanism is still unclear. In order to explore the mechanism of ginseng in the treatment of Qi-deficiency constitution, the untargeted metabonomics with blood was studied based on rapid resolution high performance liquid chromatography-quadrupole time-of-flight mass spectrometry(RRLC-Q-TOF-MS). In the results, 13 potential biomarkers were found and identified, which mainly involved in the body's antioxidant and immune functions and energy, glycerol, fatty acid, sugar metabolism and bile acid metabolism. The results of blood biochemical analysis also indicated that ginseng could regulate the body's energy metabolism, immune functions and antioxidant capacity in spleen-Qi deficiency constitution. This study revealed the mechanism of ginseng in the treatment of spleen-Qi deficiency using the blood metabonomics, which could provide technological support and scientific basis for further research on ginseng treatment of Qi-deficiency.
