Structure and function of human-derived lysozyme: a review.

Author: Ruwei LIU ¹ ; Qingyong MENG ² ; Yunping DAI ² ; Yali ZHANG ¹
Author Information

1. College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
2. College of Biological Sciences, China Agricultural University, Beijing 100193, China.
Publication Type:Journal Article
Keywords: biological functions; human lysozyme; mechanism of action; structural characteristics
MeSH: Humans; Muramidase; Anti-Bacterial Agents
From: Chinese Journal of Biotechnology 2023;39(11):4482-4496
CountryChina
Language:Chinese
Abstract: Human-derived lysozyme is a general term for a group of naturally occurring alkaline proteins in the human body that are capable of lysing bacterial cell walls. Its action is characterized by its ability to cleave the β-(1,4)-glycosidic bond between N-acetylglucosamine and N-acetylmuramic acid in peptidoglycan. Human-derived lysozyme has a variety of properties such as antibacterial, anti-inflammatory, antiviral and immune enhancing, and is therefore widely used in the domestic and international pharmaceutical markets. This review summarizes the structural features, expression sites, biological functions of human-derived lysozymes and its market applications.