Research Progress on Mechanisms of Triggeringreceptor Expressed on Myeloid Cells-2 in Cognitive Dysfunction

VernacularTitle:髓系细胞触发受体２在认知功能障碍中相关机制的研究进展
Author: Limin SHI ¹ ; Ping XU ¹
Author Information

1. Department of Neurology， Affiliated Hospital of Zunyi Medical University， Zunyi 563000， China
Publication Type:Review
Keywords: cognitive dysfunction; triggeringreceptor expressed on myeloid cells-2 （TREM2）; Alzheimer's disease; vascular dementia; Parkinson's disease; postoperative cognitive impairment; obesity
From: Journal of Sun Yat-sen University(Medical Sciences) 2024;45(1):7-12
CountryChina
Language:Chinese
Abstract: The neuroimmune system is crucial for the development， aging， and damage of the central nervous system， and has gradually become a research hotspot. Triggeringreceptor expressed on myeloid cells-2 （TREM2） is a transmembrane receptor of the immunoglobulin superfamily and is mainly expressed in the microglia in the central nervous system. An increasing number of studies indicate that TREM2 has great potential to improve cognitive dysfunction related to Alzheimer's disease， vascular dementia， Parkinson's disease， postoperative cognitive impairment， obesity， etc. However， there is a lack of a systematic summary of the specific role of TREM2 in cognitive dysfunction. This paper reviews the progress in the latest research on the related mechanisms of TREM2 in cognitive dysfunction， in order to provide new strategies for the treatment of cognitive dysfunction.