Correlation between pulmonary artery pressure and pulmonary function in chronic obstructive pulmonary disease related pulmonary hypertension
- VernacularTitle:慢性阻塞性肺疾病相关肺动脉高压中肺动脉压力与肺功能的关联性研究
- Author:
Wei ZHANG
1
;
Duo DING
2
;
Lei WANG
2
Author Information
- Publication Type:Journal Article
- Keywords: chronic obstructive pulmonary disease(COPD); pulmonary hypertension; pulmonary function
- From: Journal of Xi'an Jiaotong University(Medical Sciences) 2022;43(6):889-894
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the characteristics of chronic obstructive pulmonary disease related pulmonary hypertension (COPD-PH) patients and determine the correlation between pulmonary hypertension severity and impaired lung function severity. 【Methods】 A total of 565 patients with COPD who underwent echocardiography and estimated pulmonary artery pressure (sPAP) were recruited. According to whether sPAP was greater than 35 mmHg, the patients were divided into non-COPD-PH group (243 cases) and COPD-PH group (322 cases). According to the level of sPAP, COPD-PH patients were subdivided into mild group, moderate group, and severe group. The degree of airflow limitation in patients with COPD was divided into GOLD 1 to 4. We analyzed the general clinical data characteristics of the patients, pulmonary function indexes differences among patients with different severity of COPD-PH, and the correlation between pulmonary artery pressure and pulmonary function indexes. 【Results】 Compared with patients in the non-COPD-PH group, those in the COPD-PH group were older (P=0.001), had a higher brain natriuretic peptide(BNP) level (P<0.001) and D-dimer level (P=0.020), and a lower diffusing capacity of the lung for carbon monoxide (DLco)% predicted (P=0.001). There were significant differences in the artery partial pressure of oxygen (PaO
2 ) (P=0.017) and DLco% predicted (P=0.004) among patients with mild PH, moderate PH, and severe PH. Severe COPD-PH group had lower PaO2 compared with mild-moderate COPD-PH group, and the higher the PH severity classification, the lower the patients’ DLco% predicted. No significant differences were found in lung ventilation function indexes. There was no significant difference in sPAP among GOLD 1 to 4 groups, and distribution of PH severity and COPD airflow limitation severity was not matched. There was a significant negative correlation between sPAP and DLco% predicted, but no significant correlation between sPAP and lung ventilation indexes. 【Conclusion】 Advanced age, BNP and D-dimer can be used as important predictors for PH occurrence in COPD patients. The degree of hemodynamic impairment does not match the degree of airflow limitation, but it is significantly negatively correlated with diffusion function impairment.
