Research progress about traditional Chinese medicine in the intervention of gastric cancer by regulating Th17/Treg balance
- VernacularTitle:中药通过调节Th17/Treg平衡干预胃癌的研究进展
- Author:
Jiaqi YIN
1
;
Liqun LI
2
;
Sheng XIE
2
Author Information
1. Graduate School，Guangxi University of Traditional Chinese Medicine，Nanning 530001，China
2. Department of Spleen and Stomach Diseases，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
gastric cancer;
T helper cell 17;
T regulatory cells;
immune balance;
clinical effect
- From:
China Pharmacy
2024;35(3):379-384
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer （GC） is a common malignant tumor of the digestive tract. T helper cells 17 （Th17） and T regulatory cells （Treg） are differentiated subsets of CD4+T cells. Th17/Treg imbalance has been shown to be closely related to the progression of GC. Traditional Chinese medicine （TCM） can not only improve the survival prognosis of GC patients， but also play a role in enhancing the efficacy and reducing the toxicity of postoperative chemotherapy for GC. This paper systematically sorted out the action rules of TCM in the intervention of GC by regulating Th17/Treg balance. The results showed that the TCM compound could regulate the balance of GC Th17/Treg by invigorating the spleen and invigorating Qi， warming Yang， removing blood stasis and detoxifying. The mechanism of regulating Th17/Treg balance in the intervention of GC is mainly to inhibit the excessive differentiation of Th17 and Treg and the overexpression of transcription factors and cytokines， reverse the excessive drift of GC Th17/Treg balance to Th17 or Treg， and thus restore the immune balance of GC Th17/Treg.
