Clinical application of a novel urinary cytology detection system for bladder cancer
10.3969/j.issn.1009-8291.2023.06.007
- VernacularTitle:新型膀胱癌尿细胞学检测系统的临床应用
- Author:
Hui WANG
1
;
Wenhao SHEN
1
;
Zheng WANG
1
;
Yiran HUANG
2
Author Information
1. Department of Urology, Shanghai International Medical Center, Shanghai 200120
2. Department of Urology, Shanghai International Medical Center, Shanghai 200120; Department of Urology, Renji Hospital, School of Medicine of Shanghai Jiaotong University, Shanghai 200127, China
- Publication Type:Journal Article
- Keywords:
bladder cancer;
diagnostic kit;
diagnostic efficacy;
screening;
hematuria;
transurethral resection of bladder tumor;
urine cytology detection
- From:
Journal of Modern Urology
2023;28(6):493-496
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To investigate the diagnostic efficacy of a novel bladder cancer detection system utilizing a urine cell processing kit for urine sample preservation and detection. 【Methods】 Patients with primary persistent gross hematuria and high recurrence risk of bladder cancer after transurethral resection of bladder tumor were prospectively enrolled between Dec.2021 and Mar.2022. Urine specimens were either added to (experimental group) or not added to (control group) the urine cell processing kit and were fixed on Day 0, Day 3 and Day 7. The sensitivity and specificity of the two groups were compared after the cells were fixed, produced, stained and read with body fluid cytology total staining technique. 【Results】 The sensitivity and specificity of the experimental group on Day 0 were 82.50% (33/40) and 87.50% (14/16), respectively; those of the control group were 79.49% (31/39) and 82.35% (14/17), respectively. On Day 3, the sensitivity and specificity of the experimental group were 76.32% (29/38)and 81.25% (13/16), respectively; those of the control group were 52.78% (19/36) and 78.57% (11/14), respectively. On Day 7, the sensitivity and specificity of the experimental group were 71.43% (25/35) and 72.22% (13/18), respectively; those of the control group were 35.71% (10/28) and 60.00% (9/15), respectively. The sensitivity of the experimental group on Day 3 and Day 7 was significantly higher than that of the control group (P<0.05). 【Conclusion】 This bladder cancer urine cytology detection system provides clear diagnostic advantages and can be used as an auxiliary examination before cystoscopy for patients with hematuria and those at high risk of bladder cancer recurrence. It can also be used as a bladder cancer screening tool for pre-screening a large sample of people in order to achieve early diagnosis and treatment of bladder cancer.
