Role of cell fate regulation by ionizing radiation in radiation-induced lung injury and its therapeutic progress

Yongqing GU; Xingkun AO; Jiaojiao ZHU

Return

Role of cell fate regulation by ionizing radiation in radiation-induced lung injury and its therapeutic progress

VernacularTitle:电离辐射调控细胞命运在放射性肺损伤中的作用及治疗进展
Author: Yongqing GU ¹ ; Xingkun AO ² ; Jiaojiao ZHU ³
Author Information

1. Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School of University of South China, Hengyang 421001; Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China
2. Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School of University of South China, Hengyang 421001
3. Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing 100850, China
Publication Type:Journal Article
Keywords: ionizing radiation; radiation-induced lung injury; radiation-induced pulmonary fibrosis; cell fate
From: Journal of Xi'an Jiaotong University(Medical Sciences) 2023;44(2):153-163
CountryChina
Language:Chinese
Abstract: Radiation induced lung injury (RILI) is a common complication after radiation therapy of breast tumors and bone marrow transplantation pretreatment, and it is a critical limiting factor of radiotherapy doses in patients. Once RILI progresses to the radiation-induced pulmonary fibrosis stage, it seriously reduces the patient’s quality of life, while causing the patient’s respiratory failure and eventually leading to death. Ionizing radiation (IR) can induce cell injuries, including apoptosis, epithelial-mesenchymal transition, senescence, pyroptosis and ferroptosis, and these injuries can play an important role in the occurrence and development of radioactive lung injury. Starting from discussion of the occurrence of different forms of injury in different cells after IR stimulation, this review summarizes the pathogenesis of RILI and its clinical prevention and treatment.