Development of Acute Megakaryoblastic Leukemia with Isochromosome (12p) after a Primary Mediastinal Germ Cell Tumor in Korea.
10.3346/jkms.2011.26.8.1099
- Author:
Nae YU
1
;
Hye Ryoun KIM
;
Young Joo CHA
;
Eun Kyung PARK
;
Jeong Wook KIM
Author Information
1. Department of Laboratory Medicine, Chung-Ang University College of Medicine, Seoul, Korea. hyekim@cau.ac.kr
- Publication Type:Case Report
- Keywords:
Mediastinal Germ Cell Tumor;
Acute Megakaryoblastic Leukemia;
Isochromosome (12p)
- MeSH:
Adult;
Antineoplastic Combined Chemotherapy Protocols/therapeutic use;
Bleomycin/administration & dosage;
Bone Marrow/pathology;
*Chromosomes, Human, Pair 12;
Cisplatin/administration & dosage;
Etoposide/administration & dosage;
Humans;
Isochromosomes;
Karyotyping;
Leukemia, Megakaryoblastic, Acute/drug therapy/etiology/*genetics;
Male;
Mediastinal Neoplasms/*diagnosis/drug therapy/surgery;
Neoplasms, Germ Cell and Embryonal/*diagnosis/drug therapy/surgery;
Neoplasms, Second Primary/drug therapy/etiology/*genetics;
Republic of Korea;
Shock, Septic/pathology
- From:Journal of Korean Medical Science
2011;26(8):1099-1102
- CountryRepublic of Korea
- Language:English
-
Abstract:
The association of hematological malignancies with a mediastinal germ cell tumor (GCT) is very rare. We report one case of a young adult male with primary mediastinal GCT who subsequently developed acute megakaryoblastic leukemia involving isochromosome (12p). A 25-yr-old man had been diagnosed with a mediastinal GCT and underwent surgical resection and adjuvant chemotherapy. At 1 week after the last cycle of chemotherapy, his peripheral blood showed leukocytosis with blasts. A bone marrow study confirmed the acute megakaryoblastic leukemia. A cytogenetic study revealed a complex karyotype with i(12p). Although additional chemotherapy was administered, the patient could not attain remission and died of septic shock. This case was definitely distinct from therapy-related secondary leukemia in terms of clinical, morphologic, and cytogenetic features. To our knowledge, this is the first case report of a patient with mediastinal GCT subsequently developing acute megakaryoblastic leukemia involving i(12p) in Korea.
