Clinical treatment and management of invasive fungal disease in recipients of solid organ transplantation
10.3969/j.issn.1674-7445.2023089
- VernacularTitle:实体器官移植受者侵袭性真菌病的临床治疗管理
- Author:
Robenson Jean ARNOUX
1
;
Peijun ZHOU
1
Author Information
1. Department of Urology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
- Publication Type:ReviewArticle
- Keywords:
Solid organ transplantation;
Invasive fungal disease;
Drug-drug interaction;
Antifungal therapy;
Drug concentration monitoring;
Invasive candidiasis;
Invasive aspergillosis;
Pneumocystis jiroveci pneumonia
- From:
Organ Transplantation
2024;15(1):151-159
- CountryChina
- Language:Chinese
-
Abstract:
With widespread application of solid organ transplantation (SOT), the incidence of postoperative invasive fungal disease (IFD) in SOT recipients has been increased year by year. In recent years, the awareness of preventive antifungal therapy for SOT recipients has been gradually strengthened. However, the problem of fungal resistance has also emerged, leading to unsatisfactory efficacy of original standardized antifungal regimens. Drug-drug interaction and hepatorenal toxicity induced by drugs are also challenges facing clinicians. In this article, the characteristics of drug-drug interaction and hepatorenal toxicity among triazole, echinocandin and polyene antifungal drugs and immunosuppressants were reviewed, and postoperative preventive strategies for IFD in different types of SOT recipients and treatment strategies for IFD caused by infection of different pathogens were summarized, aiming to provide reference for physicians in organ transplantation and related disciplines.
