Imaging Characteristics of 68Ga-DOTATATE PET/CT in Tumor-Induced Osteomalacia
10.12376/j.issn.2097-0501.2023.03.010
- VernacularTitle:肿瘤性骨软化症68Ga-DOTATATE PET/CT显像特点分析
- Author:
Yuwei ZHANG
1
;
Hongli JING
1
Author Information
1. Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
- Publication Type:Journal Article
- Keywords:
68Ga-DOTATATE;
somatostatin receptor imaging;
tumor-induced osteomalacia;
PET/CT
- From:
JOURNAL OF RARE DISEASES
2023;2(3):398-405
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by tumors secreting fibroblast growth factor 23 (FGF23) that promotes urinary phosphorus excretion. Thus, TIO is typically characterized by phosphoruria, hypophosphatemia, and osteomalacia. Diagnosis and localization of the tumor is often difficult due to its small size, slow growth and concealed location. Due to the high expression of somatostatin receptors in pathogenic tumors, nuclear medicine functional imaging, particularly somatostatin receptor imaging, is used for diagnosis and localization of culprit tumors with high sensitivity and specificity. Here we retrospectively analyze 25 cases in which 68Ga-DOTATATE PET/CT successfully localized and diagnosed TIO culprit tumors. The clinical features, pathological results and image characteristics of 68Ga-DOTATATE PET/CT imaging were analyzed and compared with other imaging diagnostic techniques. It was confirmed that 68Ga-DOTATATE PET/CT imaging was the preferred imaging technique for successful diagnosis and localization of TIO pathogenic tumors.
