The Syndromes of Resistance to Thyroid Hormone Beta
10.12376/j.issn.2097-0501.2023.03.003
- VernacularTitle:β型甲状腺激素抵抗综合征
- Author:
Huangman WANG
1
;
Zhongyan SHAN
1
;
Xiaochun TENG
1
Author Information
1. Department of Endocrinology and Metabolism, Key Laboratory of Diagnosis and Treatment of Thyroid Diseases of National Health Commission, the First Affiliated Hospital of China Medical University, Shenyang 110001, China.
- Publication Type:Journal Article
- Keywords:
thyroid hormone resistance syndrome;
THRB mutations;
thyroid hormone
- From:
JOURNAL OF RARE DISEASES
2023;2(3):331-336
- CountryChina
- Language:Chinese
-
Abstract:
The syndrome of resistance to thyroid hormone(RTH) is a rare syndrome caused by the mutation of thyroid hormone receptor (TR) gene, which reduces the sensitivity of target organs to thyroid hormone (TH) and leads to the dysfunction of TH. Thyroid hormone resistance syndrome β (RTHβ) is caused by the mutations in the THRB gene. The main characteristics of RTHβ are increased thyroxine (T4) in the circulating blood, normal or elevated levels of triiodothyronine(T3), paired with normal or high thyroid-stimulating hormone (TSH) concentration. Clinically, it is easy to misdiagnose RTHβ as hyperthyroidism, and give anti-thyroid drugs, radioactive 131I therapy or surgery, which then leads to the aggravation of TH resistance, so the correct diagnosis of the disease is critical. In this paper, the molecular mechanism, clinical characteristics, diagnosis and treatment of RTHβ are summarized.
