Analysis of plasma coagulation function in male Tibetan population with different hemoglobin content in Tibet
10.13303/j.cjbt.issn.1004-549x.2021.06.004
- VernacularTitle:西藏地区不同血红蛋白含量的男性藏族人群血浆凝血功能分析
- Author:
Rui ZHONG
1
;
Xiaodong WU
2
;
Hong WANG
1
;
Xuejun ZHANG
1
;
Zeng HE
1
;
Jiaxin LIU
1
Author Information
1. Institute of Blood Transfusion, Chinese Academy of Medical Science and Pecking Union Medical College, Chengdu 610052, China
2. Tibet Autonomous Region in Chengdu Office Hospital
- Publication Type:Journal Article
- Keywords:
Tibet;
hemoglobin;
coagulation time;
coagulation factor
- From:
Chinese Journal of Blood Transfusion
2021;34(6):581-584
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To explore the correlation between blood coagulation function and hemoglobin(Hb) content in male Tibetan population in Tibet by analyzing and comparing the indexes of blood coagulation function in male Tibetan population with different Hb contents, so as to provide the basis for formulating blood donation criteria and blood component quality standard suitable for high altitude area. 【Methods】 Male Tibetans in Tibet during November 2018 to January 2019 were randomly selected and divided into three groups according to the Hb content. The healthy male volunteers in plain area were taken as the control. The plasma PT, APTT, TT, Fg, coagulation factor Ⅱ(FⅡ), FⅤ, FⅦ, FⅧ, FⅨ, FⅩ, FⅪ, FⅫ and protein C(PC) content of each group were measured and compared. 【Results】 The Fg was not different by groups(P>0.05); PT, APTT and TT in group C (Hb>210 g/L) in Tibet were significantly higher than those in controls [PT( s) : 11.48±1.18 vs 13.79±3.73; APTT( s) : 36.71±2.93 vs 43.30±4.56; TT( s) : 15.77±0.95 vs 17.94±2.43, P<0.05] ; some coagulation factors (IU / mL) decreased significantly(FⅡ: 0.98±0.10 vs 0.89±0.11; FⅤ: 0.86±0.13 vs 0.65±0.12; FⅦ: 0.93±0.18 vs 0.74±0.14; FⅩ: 0.96±0.16 vs 0.83±0.20; FⅧ: 0.79±0.08 vs 0.66±0.06; FⅪ: 0.86±0.13 vs 0.66±0.14, P<0.05); the content of ATⅢ decreased significantly(116.37±18.81 vs 96.84±14.66, P<0.05). There was no significant difference between group A (120 g/L≤Hb≤185 g/L) and group B (185 g/L0.05), except PC conctent of group A was slightly higher than that of group B. 【Conclusion】 The plasma characteristics of Tibetan male with Hb content more than 210 g/L is different from that in plain and other high altitude area, such as prolonged coagulation time and significantly decreased coagulation factor content. Therefore, it is important to put forward the health examination requirements for blood donors and quality standards for whole blood and blood components suitable for high altitude areas in Tibet.
