Clinical observations of the therapeutic effect of CLAG or FLAG bridging BuCy conditioning regimen in the treatment of childhood acute leukemia
10.13303/j.cjbt.issn.1004-549x.2022.12.010
- VernacularTitle:CLAG或FLAG桥接BuCy的预处理方案治疗儿童急性白血病的疗效观察
- Author:
Jiahui YIN
1
;
Shaoyan HU
1
;
Hailong HE
1
;
Jing LING
1
;
Jie LI
1
Author Information
1. Children′s Hospital of Soochow University, Suzhou 215000, China
- Publication Type:Journal Article
- Keywords:
cladribine;
fludarabine;
conditioning regimen;
allogeneic hematopoietic stem cell transplantation
- From:
Chinese Journal of Blood Transfusion
2022;35(12):1230-1234
- CountryChina
- Language:Chinese
-
Abstract:
【Objective】 To determine the therapeutic efficacy of cladribine combined with BuCy conditioning regimen for childhood acute leukemia, and compare it with fludarabine. 【Methods】 The clinical data of 70 children with acute leukemias who underwent all-HSCT from August 2018 to June 2020 were collected. The data of pretreatment-related toxicity, hematopoietic reconstitution, graft-versus-host disease, virus infection, relapsed and survival between CLAG and FLAG group were statistically analyzed. 【Results】 EBV infection in CLAG group was significantly more than that in FLAG group(P<0.05). There was no significant difference in RRTs, hematopoietic reconstitution, GVHD occurrence, OS and relapsed between CLAG group and FLAG group(P>0.05). Multivariate analysis showed that there was no significant difference in the effect of conditioning regimen on relapsed and survival. Among other risk factors, types of diseases were significantly correlated with OS (P<0.05, HR: 0.088). Relapse was significantly correlated with bone marrow morphological remission before transplantation and the matching degree of donor and recipient HLA(P<0.05, HR: 34.678; P<0.05, HR: 0.024). 【Conclusion】 There was no significant difference in RRTs, hematopoietic reconstitution, GVHD occurrence, OS and relapsed between CLAG group and FLAG group. The overall efficacy of CLAG group was not inferior to FLAG group.
