Artesunate Combined with Other Medications and Action Mechanism： A Review
10.13422/j.cnki.syfjx.20231736
- VernacularTitle:青蒿琥酯联合用药及作用机制研究进展
- Author:
Yuting ZHANG
1
;
Shahbaz MUHAMMAD
2
;
Rui ZHANG
3
;
Bianli WANG
2
;
Huimin ZHANG
2
Author Information
1. School of Pharmacy， Shandong University of Traditional Chinese Medicine （TCM）， Jinan 250355， China
2. State Administration of TCM High-Level Key Discipline of TCM Analysis， Shandong Academy of Chinese Medicine， Jinan 250014， China
3. Dongying Tongan Thoracic Surgery Hospital， Dongying 257300， China
- Publication Type:Journal Article
- Keywords:
artesunate;
combination therapy;
action mechanism;
antimalarial;
antitumor
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(3):290-298
- CountryChina
- Language:Chinese
-
Abstract:
A sesquiterpene natural substance called artemisinin was discovered in Artemisia annua. One of its derivatives， artesunate （ART）， has the properties of economy， immediate effect， low toxicity， and good tolerance. Since it has a quick and powerful killing effect on plasmodium in the erythrocyte phase and can quickly handle clinical seizure and symptoms， it is currently mostly utilized to treat cerebral malaria and other severe instances of malaria. In addition， it has antitumor， antivirus， anti-hepatic fibrosis， anti-inflammatory， antibacterial， hepatocyte protection， immunological modulation， and other pharmacological properties and can inhibit cell proliferation， induce cell apoptosis， and reduce the incidence of sepsis. In many countries， artemisinin-based combination therapies （ACTs）， such as artemether-benflumetol， artesunate-amodiaquine， and artemether-lumefantrine， are the first-line treatments for malaria. Recent research on artesunate by Chinese and international scholars has revealed that compared with monotherapy， artesunate combination therapy offers more benefits in terms of improving pharmacological effects， shortening the duration of medicine， and minimizing adverse effects. Through systematic retrieval of Web of Science Core Collection and integration through CiteSpace （6.2.1） software， this article reviewed the mechanism of artesunate combined with other medications with regard to antimalarial， antitumor， antibacterial， and antiviral features in the previous five years， so as to provide some theoretical basis for rational development and utilization of ART and new drug research and development.
