Precise Clinical Positioning of Chinese Patent Medicine in Paradigm of "Target Spectral Effect of Prescription"： A Case Study of Qizhi Tongluo Capsules
10.13422/j.cnki.syfjx.20240693
- VernacularTitle:基于方剂靶点谱效关系的中成药临床精准定位模式探索——以芪蛭通络胶囊为例
- Author:
Yanan YU
1
;
Bing LI
2
;
Jun LIU
1
;
Zhong WANG
1
Author Information
1. Institute of Basic Research in Clinical Medicine，Chinese Academy of Chinese Medical Sciences，Beijing 100700，China
2. Institute of Chinese Materia Medica，Chinese Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Journal Article
- Keywords:
fangjiomics;
clinical positioning;
target spectral effect;
precise evidence-based;
Qizhi Tongluo capsules
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(3):98-104
- CountryChina
- Language:Chinese
-
Abstract:
The clinical value of Chinese patent medicine is the core direction of the development of the traditional Chinese medicine industry. The precise clinical positioning determines the way to prove the value of the drug， and is a key link to highlight the clinical value. This paper presented a case study of clinical positioning for Chinese patent medicine， namely Qizhi Tongluo capsules， and the key technical framework of precise clinical positioning of Chinese patent medicine， which was manifested as a comparison of prescription target spectral effect， discovery of core value of prescription， and confirmation of clinical positioning trial. The technical framework was designed to address a range of issues in the realm of precise clinical positioning. Before the clinical positioning trial， based on the multi-component， multi-target， and multi-phenotype data of prescription and clinical indication， the multi-omics network analysis technology was used to identify the core value of the traditional Chinese medicine varieties and predict the potential clinical advantages. Then， based on the predicted clinical advantages， reasonable efficacy indicators were selected， and the clinical efficacy was judged and verified by dynamic and flexible innovative clinical trials to improve the success rate of clinical positioning. This research paradigm integrates "omics technology" with "evidence-based" principles and follows the "precise evidence-based" concept. This research aims to provide a new strategy and method for the precise medication and positioning of Chinese patent medicine with traditional Chinese medicine characteristics after being put into the market and provide more technical thinking for traditional Chinese medicine to move towards precise medicine.
