Evaluation of the therapeutic effect of deuterium depleted water on gastroenteritis induced by 131I radiation in thyroid cancer treatment
10.13491/j.issn.1004-714X.2023.05.012
- VernacularTitle:低氘水对131I治疗甲状腺癌致辐射性胃肠炎的疗效评价
- Author:
Jing ZHU
1
;
Xiaoyi ZHANG
1
;
Chao SHEN
2
;
Zhihong XU
3
;
Wei CHEN
3
Author Information
1. Department of Nuclear Medicine, Changshu No.2 People’s Hospital, Changshu 215500 China;State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123 China.
2. Department of Nuclear Medicine, Changshu No.2 People’s Hospital, Changshu 215500 China.
3. Suzhou Sicui Institute of Isotope Technology Company, Ltd, Changshu 215500 China.
- Publication Type:OriginalArticles
- Keywords:
Deuterium depleted water;
Thyroid cancer;
Radiation-induced gastroenteritis;
Evaluation of therapeutic effect;
131I
- From:
Chinese Journal of Radiological Health
2023;32(5):538-541
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the therapeutic effect of oral administration of deuterium depleted water on gastroenteritis induced by 131I radiation in thyroid cancer treatment. Methods Fifty patients with papillary thyroid cancer treated with 131I in the Department of Nuclear Medicine of Changshu No.2 People’s Hospital from May 2022 to February 2023 were divided into control group and experimental group (25 patients in each group). Data were continuously collected throughout the study duration. The control group was orally administrated omeprazole enteric-coated capsules and purified water at 660 mL tid for 5 days. The experimental group received the same basic treatment as the control group except that deuterium depleted water was used instead of purified water. The incidence and alleviation of 131I radiation-induced gastroenteritis were observed and compared between the two groups using the Fisher’s exact test and Kaplan-Meier analysis. Results The number of gastroenteritis cases from day 1 to day 5 after 131I administration was 2 (8%), 5 (20%), 2 (8%), 1 (4%), and 0 (0%), respectively, in the experimental group, and 2 (8%), 8 (32%), 4 (16%), 3 (12%), and 1 (4%), respectively, in the control group. The incidence of gastroenteritis was significantly different between the two groups (χ2=4.064, P=0.044). After 5 days of treatment, the overall response rate of patients in the experimental group was 96%, which was significantly higher than 76% in the control group (χ2=9.105, P=0.025). Conclusion Oral administration of deuterium depleted water is effective in the relief of clinical symptoms of 131I radiation-induced gastroenteritis in thyroid cancer treatment. The clinical application of deuterium depleted water should be further investigated.
