Objective:To compare the efficacy,feasibility and safety of laparoscopic transcystic common bile duct exploration(LTCBDE)and laparoscopic common bile duct exploration(LCBDE)in treatment of common bile duct stones.Methods:The relevant studies publicly published from 2009 to 2019 were collected by searching several national and international databases.After literature screening according to the predefined criteria,Meta-analysis was performed by Stata12.0 SE software.Results:A total of 21 studies were finally included,involving 3 804 patients with 1 939 cases in LTCBDE group and 1 865 cases in LCBDE group.The results of Meta-analysis showed that the stone clearance rate in LTCBDE group was significantly higher than that in LCBDE group(OR=1.51,95%CI=1.02-2.25,P=0.038),and the perioperative variables that include intraoperative blood loss(MD=-54.16,95%CI=-101.07--7.26),operative time(MD=-27.27,95%CI=-35.20--19.33),postoperative tube retention time(MD=-1.97,95%CI=-2.32--1.63),length of hospital stay(MD=-3.04,95%CI=-3.58--2.51)and hospitalization cost(MD=-3 554.99,95%CI=-4 209.66--2 900.32)in LTCBDE group were all superior to those in LCBDE group(all P<0.05);the incidence rates of postoperative bile leakage(OR=0.28,95%CI=0.19-0.40),cholangitis(OR=0.33,95%CI=0.14-0.80),biliary stricture(OR=0.32,95%CI=0.11-0.91)and the overall complications(OR=0.33,95%CI=0.25-0.43)in LTCBDE group were all significantly lower than those in LCBDE group(all P<0.05),and no significant differences were noted in the incidence rates of postoperative pancreatitis(OR=0.56,95%CI=0.24-1.32)and biliary tract injury or bleeding(OR=0.64,95%CI=0.24-1.71)between the two groups(both P>0.05).Conclusion:For common bile duct stones,LTCBDE is safer and more effective than LCBDE.So,it is recommended to be used in clinical practice.

Objective:To compare the efficacy,feasibility and safety of laparoscopic transcystic common bile duct exploration(LTCBDE)and laparoscopic common bile duct exploration(LCBDE)in treatment of common bile duct stones.Methods:The relevant studies publicly published from 2009 to 2019 were collected by searching several national and international databases.After literature screening according to the predefined criteria,Meta-analysis was performed by Stata12.0 SE software.Results:A total of 21 studies were finally included,involving 3 804 patients with 1 939 cases in LTCBDE group and 1 865 cases in LCBDE group.The results of Meta-analysis showed that the stone clearance rate in LTCBDE group was significantly higher than that in LCBDE group(OR=1.51,95%CI=1.02-2.25,P=0.038),and the perioperative variables that include intraoperative blood loss(MD=-54.16,95%CI=-101.07--7.26),operative time(MD=-27.27,95%CI=-35.20--19.33),postoperative tube retention time(MD=-1.97,95%CI=-2.32--1.63),length of hospital stay(MD=-3.04,95%CI=-3.58--2.51)and hospitalization cost(MD=-3 554.99,95%CI=-4 209.66--2 900.32)in LTCBDE group were all superior to those in LCBDE group(all P<0.05);the incidence rates of postoperative bile leakage(OR=0.28,95%CI=0.19-0.40),cholangitis(OR=0.33,95%CI=0.14-0.80),biliary stricture(OR=0.32,95%CI=0.11-0.91)and the overall complications(OR=0.33,95%CI=0.25-0.43)in LTCBDE group were all significantly lower than those in LCBDE group(all P<0.05),and no significant differences were noted in the incidence rates of postoperative pancreatitis(OR=0.56,95%CI=0.24-1.32)and biliary tract injury or bleeding(OR=0.64,95%CI=0.24-1.71)between the two groups(both P>0.05).Conclusion:For common bile duct stones,LTCBDE is safer and more effective than LCBDE.So,it is recommended to be used in clinical practice.

Objective To investigate the feasibility and effectiveness of focused ultrasound on the acne of rabbit ear.Methods Eighteen male rabbits were randomly divided into blank control group,model control group and ultrasound irradiation group.Acne rabbit ear model was established by Kligman's method in model control group and ultrasound irradiation group.Then,continuous ultrasonic irradiation was given in ultrasound irradiation group.Pathological changes were observed at the time of before and after ultrasound irradiation and 14 days after ultrasound irradiation.Results After modeling,hair follicle expansion,hyperkeratosis,acupoint hypertrophy were observed in blank control group.Compared with blank control group,the thickness of horn layer,the sebaceous gland diameter and other index in model controlgroup were statistically significant (P＜0.01);After irradiation,there were hyperemia and edema in epidermis,angiotelectasis and inflammatory infiltrating,but coagulative necrosis in slice was not observed,14 days later,hair follicle mild expansion,mild keratosis,spiny thinning were observed in ultrasound irradiation group,when compared with model control group,the thickness of horn layer,sebaceous gland diameter and other index were decreased in ultrasound irradiation group,and the differences were statistically significant(P＜0.01).Conclusion The ultrasonic focusing treatment on rabbit ear acne is feasible and effective.