BACKGROUND

Pulmonary aspergilloma is the most common pulmonary involvement due to Aspergillus. It usually develops in a pre-existing cavity in the lung, most often due to tuberculosis. Hemoptysis occurs secondary to local invasion of the blood vessels lining the cavity. Recurrence of which, is an indication to do surgery, lobectomy in particular. Antifungals like amphotecin B given intravenously and itraconazole given orally, have been the traditional management. But with the emergence of newer antifungals, Echinocandins in particular, which functions to inhibit the β-(1,3) p-glucan synthase, an enzyme necessary for the synthesis of an essential component of the cell wall of fungi, one may need not undergo surgery. The most common antifungal medication for Aspergillus is voriconazole, a second-generation triazole. This case demonstrates the efficient utilization of Voriconazole along with Anidulafungin, which is necessary for the fungal cell wall integrity. For immunocompromised patients with pulmonary aspergilloma, this dual therapy presents a viable substitute for surgical intervention and an efficient treatment approach.

CASE

We present a case of a 54-year-old married patient, who presented with massive hemoptysis four days before consulting a private physician. She had ten episodes of hemoptysis four hours before admission and was rushed to the hospital. The patient had multiple comorbidities, including diabetes, hypertension, and asthma, contributing to an immunocompromised state. She had a history of anti-tuberculosis treatment in 2000, which was discontinued due to an allergic reaction. During her hospital stay, she experienced febrile episodes, and capillary glucose monitoring was beyond acceptable levels, prompting antibiotic initiation. A chest CT scan revealed pulmonary tuberculosis with cicatricial atelectasis of the lingular segment and infected cavitary formation. A bronchoscopy and biopsy of the cavitary lesion were scheduled. Surgical intervention, particularly lobectomy, was not pursued due to multiple factors, including the patient's immunocompromised status, her underlying comorbidities, and the response to antifungal therapy. After eight to 14 fourteen (8-14) hospital days, no episodes of hemoptysis were noted, and the biopsy result revealed fungal colonization consistent with Aspergillus species. The patient was discharged with oral Voriconazole and other maintenance medications. A repeat chest CT scan after five months of antifungal therapy showed regression of the fungus ball.

CONCLUSION

In this case, pulmonary aspergilloma in an immunocompromised patient was successfully treated with a combination antifungal therapy utilizing anidulafungin and voriconazole. The favorable clinical response to dual antifungal therapy provides a feasible non-surgical alternative to surgical intervention, which has historically been the preferred option for treating recurrent hemoptysis, particularly in high-risk patients. The fungus ball's regression and the fungal infection's resolution support the growing role of more recent antifungal medications in the treatment of complicated pulmonary infections. This case suggests that echinocandins combined with triazole therapy are a viable less invasive treatment option for pulmonary aspergilloma than surgery.

Human ; Female ; Middle Aged: 45-64 Yrs Old ; Anidulafungin ; Immunocompromised Host ; Patients ; Therapeutics ; Voriconazole

Influencing Factors of Adult Pulmonary Tuberculosis Patients's Clinical Improvement at the End of Intensive Phase at Public Health Care in Central Jakarta, Indonesia ntroductionClinical improvement at the end of the intensive phase is one of the indicators of the Directly Observed Therapy Shortcourse (DOTS) program used to evaluate the success of tuberculosis (TB) therapy. This study aimed to identify factors influencing clinicalimprovement among adult pulmonary TB patients at the end of intensive phase in public health centers in Central Jakarta.MethodsThis was an observational analytic study employing a case–control design with a convenience sampling method. The study population comprised 281 adult pulmonary TB patients who had completed the intensive phase of treatment at three health centers in Central Jakarta: Johar Baru, Tanah Abang, and Gambir. Data were obtained from medical records in the Sistem Informasi Tuberkulosis (SITB) database for the treatment period from July 2023 to June 2024. Bivariate analysis using the chi-square test was conducted todetermine the association between variables.ResultsBivariate analysis revealed that age, comorbidities, and initial nutritional status were significantly associated with clinical improvement among pulmonary TB patients.ConclusionsClinical improvement among adult pulmonary TB patients at public health centers in Central Jakarta is influenced by several factors, particularly age, comorbidities, and initial nutritional status.

Aims: This study was designed to evaluate awareness and knowledge of pelvic inflammatory disease (PID), its risk factors and diagnostic procedures among female undergraduates in tertiary institutions in Rivers State, Nigeria. Methodology and results: A questionnaire-based survey design was conducted among 325 undergraduate students. Completed questionnaires were retrieved immediately. Descriptive and inferential (chi-square test) statistical tools were used for data analysis. Out of the 325 respondents, 186(57.2%) had heard of PID, 162(49.8%) did not know the possible risk factors of PID, 161(49.5%) perceived their awareness level of PID to be poor, while 30(9.2%) had good awareness level of PID. The majority 185(56.9%) of the respondents, do not know the mode of transmission of PID. There was a statistically significant relationship between the student’s age and the level of awareness statement at (p<0.05). On the student’s knowledge, only the statement: Do you know PID could be symptomless, showed a statistically significant relationship with the student’s course of study (χ2=12.815, p=0.00). Conclusion, significance and impact of study Most respondents have heard of PID via social media and seminars and have even seen those who had the disease. They still claim that their awareness level was poor since they do not know the mode of transmission and ill effects of PID, and so they cannot be protected against the disease. A sensitization campaign on risk factors, symptoms and mode of spread of the disease has to be carried out in the institutions to save the students at high risk of the infection.
Pelvic Inflammatory Disease ; Student Health Services

The Malaysian population is aging, and the elderly are less healthy than the young. The majority of the elderly remain in their own home, although some choose to live in a pondok and others are institutionalized. The main concern in the care of the elderly is maintaining the quality of life (QOL) up to the last moment. The aim of this study is to determine the effect of living place (home, pondok, or old folks’ home) on QOL of the elderly in Kelantan, Malaysia. Four-hundred seventy-one respondents participated in this cross-sectional study. Participants age 60 years old and above were selected conveniently and the WHOQOL-BREF questionnaire was administered by face to face interview to measure quality of life. Multivariate analysis of variance was applied to detect the impacts and p-value < 0.05 was considered significant. Significant differences in mean score of physical (p = 0.011), psychological (p < 0.001), social (p < 0.001), and environmental (p = 0.001) aspects of QOL were detected among participants living at home, in a pondok, and in an old folks’ home. The elderly living in their own home had the highest scores in the physical, social, and environmental domains. Those living in a pondok scored highest in the psychological domain. The elderly living in an old folks’ home had the lowest scores in all domains. A significant effect of living place on QOL of the elderly was detected (p < 0.001) and there was a significant effect of living place on QOL after medical illness and age were controlled (p < 0.001,). Conclusion: Living place had a significant effect on QOL of the elderly, with best QOL for own home living elderly. We recommend elderly should remain in their own home till the end of their life.
Aged

Introduction: Colorectal cancer (CRC) is one of the leading cancers in Malaysia where new cases are increasing every year. The aim of this study was to test the reliability and validity of a newly developed questionnaire on knowledge, attitude and dietary practices (KAP) related to CRC for the Malay population. Methods: The respondents were conveniently selected among visitors attending an outpatient clinic in a tertiary hospital. We excluded those with any cancers, chronic diseases and those that were illiterate. The exploratory factor and reliability analyses were conducted. Results: A total of 108 respondents were recruited of which 67.7% were males and the mean age was 54.59 years (standard deviation 8.93). The Kaiser-Meyer-Olkin (KMO) measure of sampling adequacy values for KAP were 0.64, 0.66 and 0.67, respectively (P < 0.001). The 17 items of knowledge formed five domains with loading factors ranging from 0.54–0.89. The six items of attitude formed two domains with loading factors ranging from 0.64–0.80 and the 15 practices had four domains with loading factors ranging from 0.52–0.83. The total variances explained for each KAP were 61.02%, 56.41% and 53.12%, respectively. The internal consistency Cronbach alpha values on KAP were 0.61, 0.60 and 0.70, respectively. Conclusion: The final questionnaire is suitable for measuring KAP related to CRC among the Malay population.