Objective:To explore the clinical characteristics and identification of the independent risk factors for disease progression in patients with anti-gp210 antibody-positive primary biliary cholangitis (PBC).Methods:A retrospective cohort study was performed. A total of 323 cases with PBC diagnosed in Tianjin Medical University General Hospital from January 2013 to June 2023 (125 patients with anti-gp210 antibody-positive and 198 patients with anti-gp210 antibody-negative) were included. Baseline and follow-up data were collected. The independent sample t-test and Mann-Whitney U rank sum test were used for comparison between groups of continuous data. The χ2 test was used to compare the data between groups for the count data. The Pearson test was used for correlation analysis between continuous variables. The Kaplan-Meier method was used to analyze the disease progression-free survival rate. The Cox regression model was used to analyze the risk factors for disease progression. Results:The male proportion (11.2% vs. 5.1%, P=0.040) and IgM level [3.29(1.88, 4.80) g/L vs. 2.56(1.44, 3.87) g/L, P=0.019] were significantly higher in patients with PBC with positive anti-gp210 antibodies than those of the negative group. Histopathological analysis showed that the Scheuer score [1(0,3) vs. 0(0,2)], bile duct inflammation [(2(1,3) vs. 1(1,2)] and bile duct reaction score [(2(1,3) vs. 1(1,2)] were higher in the positive group than those of the negative group ( P<0.05), and the maturity of the tertiary lymphoid structure was higher ( P=0.011). Kaplan-Meier analysis showed that the 5-year disease-free survival rate was significantly lower in patients with positive anti-gp210 antibodies than that of the negative group (55.8% vs. 79.7%, P=0.006) at a median follow-up of 3(2,6) years. Multivariate Cox regression analysis showed that γ-glutamyl transferase [ HR=1.002 (95% CI: 1.000～1.003)] and platelet count [ HR=0.993 (95% CI: 0.988～0.999)] were the independent influencing factors for disease progression in patients with anti-gp210 antibody-positive PBC ( P=0.002, 0.017). Conclusion:Patients with anti-gp210 antibody-positive PBC have more severe clinical pathological manifestations and a higher risk of disease progression. Higher levels of γ-glutamyl transferase and lower platelet counts during the first visit are independent risk factors for disease progression in patients with anti-gp210 antibody-positive PBC, which can be used as dynamic monitoring indicators for this population, suggesting the need for early intensive intervention.

Objective:To explore the clinical characteristics and identification of the independent risk factors for disease progression in patients with anti-gp210 antibody-positive primary biliary cholangitis (PBC).Methods:A retrospective cohort study was performed. A total of 323 cases with PBC diagnosed in Tianjin Medical University General Hospital from January 2013 to June 2023 (125 patients with anti-gp210 antibody-positive and 198 patients with anti-gp210 antibody-negative) were included. Baseline and follow-up data were collected. The independent sample t-test and Mann-Whitney U rank sum test were used for comparison between groups of continuous data. The χ2 test was used to compare the data between groups for the count data. The Pearson test was used for correlation analysis between continuous variables. The Kaplan-Meier method was used to analyze the disease progression-free survival rate. The Cox regression model was used to analyze the risk factors for disease progression. Results:The male proportion (11.2% vs. 5.1%, P=0.040) and IgM level [3.29(1.88, 4.80) g/L vs. 2.56(1.44, 3.87) g/L, P=0.019] were significantly higher in patients with PBC with positive anti-gp210 antibodies than those of the negative group. Histopathological analysis showed that the Scheuer score [1(0,3) vs. 0(0,2)], bile duct inflammation [(2(1,3) vs. 1(1,2)] and bile duct reaction score [(2(1,3) vs. 1(1,2)] were higher in the positive group than those of the negative group ( P<0.05), and the maturity of the tertiary lymphoid structure was higher ( P=0.011). Kaplan-Meier analysis showed that the 5-year disease-free survival rate was significantly lower in patients with positive anti-gp210 antibodies than that of the negative group (55.8% vs. 79.7%, P=0.006) at a median follow-up of 3(2,6) years. Multivariate Cox regression analysis showed that γ-glutamyl transferase [ HR=1.002 (95% CI: 1.000～1.003)] and platelet count [ HR=0.993 (95% CI: 0.988～0.999)] were the independent influencing factors for disease progression in patients with anti-gp210 antibody-positive PBC ( P=0.002, 0.017). Conclusion:Patients with anti-gp210 antibody-positive PBC have more severe clinical pathological manifestations and a higher risk of disease progression. Higher levels of γ-glutamyl transferase and lower platelet counts during the first visit are independent risk factors for disease progression in patients with anti-gp210 antibody-positive PBC, which can be used as dynamic monitoring indicators for this population, suggesting the need for early intensive intervention.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.

Objective To explore the impact of digital upgrading of public hospitals on operational efficiency,and to provide theoretical and practical guidance for the application of digital technology in the medical field.Methods The digital transformation of H hospital were collected through semi-structured interviews and field observations,and the exploratory single case study method was used for analysis and discussion.Results Digital upgrading significantly improved the operational efficiency of public hospitals by promoting information flow,strengthening hospital gover-nance and optimizing human resource allocation.Hospital culture,organizational structure and information literacy af-fected the effect of digital upgrading.Conclusion Digital upgrading has played a positive role in improving the opera-tional efficiency of public hospitals.In order to maximize its benefits,hospitals can strengthen the top-level design of digital construction,strengthen the cultivation of compound talents,pay attention to data governance and infor-mation security,promote departmental coordination and promote the iterative upgrading of digital reform.