1.Mechanisms and multimodal treatment of neuropathic pain associated with degenerative cervical spondylosis: Current status and progress.
Jianxiong ZHUANG ; Yizhang MO ; Zongyuan DENG ; Changxiang LIANG ; Dong YIN
Journal of Central South University(Medical Sciences) 2024;49(11):1840-1848
Degenerative cervical spondylosis is a common spinal disorder in the elderly. During its progression, structural changes such as intervertebral disc degeneration, vertebral osteophyte formation, and facet joint degeneration directly impact neural structures, resulting in neuropathic pain. Moreover, the release of inflammatory mediators can further exacerbate pain, and increased neuronal excitability is considered one of the key pathological mechanisms of neuropathic pain. Current diagnostic and assessment methods for neuropathic pain associated with degenerative cervical spondylosis include clinical evaluation, imaging techniques (such as X-ray, computed tomography, and magnetic resonance imaging), and neurophysiological examinations (including electromyography and nerve conduction studies). Treatment options primarily involve pharmacological therapy, physical therapy, and surgical intervention, which have shown promising short-term outcomes. Despite progress made through the combined use of various treatment modalities, their long-term efficacy and safety remain to be further investigated. Personalized and multimodal treatment strategies are essential for improving patients' quality of life. Future research should continue to explore pain mechanisms and develop innovative therapeutic techniques to optimize clinical management.
Humans
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Spondylosis/therapy*
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Neuralgia/diagnosis*
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Combined Modality Therapy
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Cervical Vertebrae
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Intervertebral Disc Degeneration/complications*
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Physical Therapy Modalities
2.Research of joint-robotics-based design of biomechanics testing device on human spine.
Guoyong DENG ; Lianfang TIAN ; Zongyuan MAO
Journal of Biomedical Engineering 2009;26(6):1246-1249
This paper introduces the hardware and software of a biomechanical robot-based testing device. The bottom control orders, posture and torque data transmission, and the control algorithms are integrated in a unified visual control platform by Visual C+ +, with easy control and management. By using hybrid force-displacement control method to load the human spine, we can test the organizational structure and the force state of the FSU (Functional spinal unit) well, which overcomes the shortcomings due to the separation of the force and displacement measurement, thus greatly improves the measurement accuracy. Also it is esay to identify the spinal degeneration and the load-bearing impact on the organizational structure of the FSU after various types of surgery.
Algorithms
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Biomechanical Phenomena
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Equipment Design
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Humans
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Joints
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physiology
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Robotics
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instrumentation
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methods
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Software
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Spine
;
physiology

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