1.Differentiation and Treatment of Chronic Heart Failure Based on Theory of "Harmony When Conforming to Qi and Illness When Going Against Qi"
Zongyi LIU ; Yan ZHANG ; Hongyu CUI
Chinese Journal of Experimental Traditional Medical Formulae 2026;32(3):239-250
Chronic heart failure (CHF) represents the terminal stage of numerous cardiovascular diseases. According to traditional Chinese medicine theory, the pathogenesis of CHF is characterized by deficiency of the root and excess of the branch. The deficiency of the root mainly stems from insufficiency of heart Qi, while the excess of the branch arises from pathological accumulation of phlegm, blood stasis, and fluid retention. During the occurrence and development of CHF, the disobedience of heart Qi consistently serves as the key to the onset of the disease. As elucidated in Da Lun Chapter of WU Yun Xing in The Yellow Emperor's Inner Classic: Plain Questions, "harmony when conforming to qi and illness when going against Qi". This principle describes the relationship between human physiology and nature Qi dynamics. Harmony leads to health, while disobedience leads to illness. The same principle can be applied within the human body, that is, harmony between the zang-fu organs and their Qi leads to health, while disobedience leads to illness. The occurrence of CHF and the relationship between the heart and heart Qi also follow this principle. This study started from this theory, analyzed the relationship between "following or going against Qi" and the occurrence of diseases in the human body, further analyzing the "following" and "going against" between the heart and heart Qi, the pathogenesis of CHF, the corresponding relationship between the heart Qi and modern physiology in the state of "following Qi", the corresponding situation between the heart Qi and modern pathology in the state of "going against Qi", and the relationship between "going against Qi" and different stages of CHF. Moreover, it proposed to treat CHF from the perspective of "illness when going against Qi". One is to replenish the insufficiency of heart Qi (tonifying heart Qi and also invigorating the spleen), and the other is to unblock the channels of heart Qi (resolving phlegm and removing turbidity to unblock the channels, removing blood stasis and dredging collaterals to promote blood circulation, and transforming fluid retention and expelling water to facilitate blood flow). Meanwhile, the effects of single-herb Chinese medicines and Chinese-medicine compound prescriptions on the myocardium and micro-indexes of the human body under the "tonifying" and "unblocking" methods were analyzed. Through the above-mentioned treatment methods, the nature of heart Qi can finally be restored to "abundant" and "unobstructed", so that the heart Qi can be harmonized and CHF can be improved. These findings may provide a new way of thinking for the future treatment of CHF.
2.Differentiation and Treatment of Chronic Heart Failure Based on Theory of "Harmony When Conforming to Qi and Illness When Going Against Qi"
Zongyi LIU ; Yan ZHANG ; Hongyu CUI
Chinese Journal of Experimental Traditional Medical Formulae 2026;32(3):239-250
Chronic heart failure (CHF) represents the terminal stage of numerous cardiovascular diseases. According to traditional Chinese medicine theory, the pathogenesis of CHF is characterized by deficiency of the root and excess of the branch. The deficiency of the root mainly stems from insufficiency of heart Qi, while the excess of the branch arises from pathological accumulation of phlegm, blood stasis, and fluid retention. During the occurrence and development of CHF, the disobedience of heart Qi consistently serves as the key to the onset of the disease. As elucidated in Da Lun Chapter of WU Yun Xing in The Yellow Emperor's Inner Classic: Plain Questions, "harmony when conforming to qi and illness when going against Qi". This principle describes the relationship between human physiology and nature Qi dynamics. Harmony leads to health, while disobedience leads to illness. The same principle can be applied within the human body, that is, harmony between the zang-fu organs and their Qi leads to health, while disobedience leads to illness. The occurrence of CHF and the relationship between the heart and heart Qi also follow this principle. This study started from this theory, analyzed the relationship between "following or going against Qi" and the occurrence of diseases in the human body, further analyzing the "following" and "going against" between the heart and heart Qi, the pathogenesis of CHF, the corresponding relationship between the heart Qi and modern physiology in the state of "following Qi", the corresponding situation between the heart Qi and modern pathology in the state of "going against Qi", and the relationship between "going against Qi" and different stages of CHF. Moreover, it proposed to treat CHF from the perspective of "illness when going against Qi". One is to replenish the insufficiency of heart Qi (tonifying heart Qi and also invigorating the spleen), and the other is to unblock the channels of heart Qi (resolving phlegm and removing turbidity to unblock the channels, removing blood stasis and dredging collaterals to promote blood circulation, and transforming fluid retention and expelling water to facilitate blood flow). Meanwhile, the effects of single-herb Chinese medicines and Chinese-medicine compound prescriptions on the myocardium and micro-indexes of the human body under the "tonifying" and "unblocking" methods were analyzed. Through the above-mentioned treatment methods, the nature of heart Qi can finally be restored to "abundant" and "unobstructed", so that the heart Qi can be harmonized and CHF can be improved. These findings may provide a new way of thinking for the future treatment of CHF.
3.The change trend analysis of incidence of intracerebral hemorrhage in Tengzhou City,Shandong Province from 2013 to 2021
Xin WANG ; Jinghua FAN ; Yuluan XU ; Nana YAN ; Xianli SONG ; Wen HUANG ; Li CHENG ; Liyu ZHOU ; Hongyu ZHU ; Shujun YE ; Zongyi WU ; Fengping ZHAO ; Fuzhong SI
Chinese Journal of Neurology 2023;56(7):770-779
Objective:To analyze the changing trend of intracerebral hemorrhage (ICH) incidence among residents with different characteristics during 9 years of comprehensive hypertension prevention and control (hypertension prevention and control) in Tengzhou from 2013 to 2021.Methods:From January 1, 2013 to December 31, 2021, the new ICH cases collected by the Center for Disease Control and Prevention in Tengzhou City were analyzed to calculate the incidence of ICH, and the trend of its distribution was analyzed among residents with different ages, sexes, and between urban and rural areas. The registered population information came from Tengzhou Public Security Bureau. Age and sex standardized incidence was calculated based on the 7th National Population Census in 2020. The Cochran-Armitage test was used to analyze the time and age trends of the incidence.Results:The overall ICH crude and standardized incidence in Tengzhou City decreased from 97.30/100 000 to 52.13/100 000 ( Z=-9.93, P<0.001) and 119.30/100 000 to 50.69/100 000 ( Z=-15.40, P<0.001) from 2013 to 2021, and both elevated to form a single peak in 2020, with 22.58% ( χ 2=24.02, P<0.001) and 18.09% ( χ 2=17.08, P<0.001) higher than in 2019, respectively. The trends in male and female incidence over the same period were similar to the overall trends, and the incidence was higher in males than in females in all years. The incidence of ICH increased with age in all years. The difference of increase in male incidence rate in 2020 was statistically significant in three age groups ≥45 years compared with 2019 (36.29%, 23.57% and 16.18%, respectively, χ 2=6.73, 4.65, 4.00, P<0.001). The incidence of ICH decreased by 70.07% and 36.23% ( Z=18.44, 5.22, P<0.001) in urban and rural areas respectively from 2013 to 2021, whereas increased by 34.15% ( χ 2=10.88, P<0.01) and 22.08% ( χ 2=18.63, P<0.001) in 2020 compared with 2019 separately. Conclusions:The incidence of ICH in Tengzhou from 2013 to 2021 showed a significant downward trend, with the decrease in the incidence of ICH in women exceeding that in men. The decrease in the incidence of ICH in urban areas exceeded that in rural areas, and male morbidity seemingly had a younger trend.
4.Comparative study of occupation burnout of southern and northern Xinjiang soldiers
Zongyi SU ; Kui DING ; Yan GU ; Penglin ZHAO
Chinese Journal of Behavioral Medicine and Brain Science 2014;23(5):451-453
Objective To explore the differences of occupation burnout of the soldiers in southern and northern Xinjiang and explore its related influencing factors.Methods Using stratified randomization sampling method,500 soldiers from south and north of xinjiang military were selected and investigated by Military Job Burnout Scale and Military Social Support Rating Scale.Results ① The military of northern soldiers'accomplishment,somatization,interpersonal relationship,social support score (5.57±3.29,5.53± 3.35,3.38±2.75,9.62± 10.15) was significantly higher than the soldiers who live in south of xinjiang (5.26±3.25,5.13±3.45,2.94±2.39,6.25±5.24) (t=2.091,-2.539,-4.011,7.227,P<0.05).②Every dimensions of occupation bumout has significant correlation with social support,age,length of military service,marriage,level,working hours,income and job satisfaction (r=0.124,0.220,0.275,0.198,0.192,0.206,0.188,-0.383,P<0.05).The total score of Military Job Bumout Scale has positive correlation with social support and level (r=0.122、0.410,P<0.01).③Social support,working hours,job satisfaction and length of military service has forecast effect on the northern military occupation bumout.Social support and level can predict the southern military occupation burnout.Conclusion It is no obviously differences on the general occupational between the north and South Xinjiang Military.Social support is closely related to the job burnout of South and the North military.
5.Progress in the research on hemodynamics of portal hypertension.
Fang SHEN ; Zongyi YAN ; Weiguang ZHANG
Journal of Biomedical Engineering 2003;20(2):332-335
Portal hypertension (PHT), as a disease with high incidence all over the world, badly affects the patients' health. The research on hemodynamics plays an important role in exploring the pathogenesis of PHT, assessing the risk of hemorrhage induced by the complications, selecting the scheme and time of surgical operations as well as evaluating the curative effects of medication. In this article, the main factors in the pathogeny of PHT are reviewed and the surgical treatments are discussed from the hemodynamic viewpoint. Then some recent results in the hemodynamic research of PHT are summarized. In addition, main ideas are put forward as to establishing a new global biomechanical model of PHT.
Animals
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Hemodynamics
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Humans
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Hypertension, Portal
;
etiology
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physiopathology
;
surgery
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Models, Cardiovascular
6.Effect of Radiation with 60Co on RBC Membrane Elastic Shear Modulus and Membrane Viscosity
Kai CHEN ; Lide XIE ; Weijuan YAO ; Zongyao WEN ; Zhangping ; Zongyi YAN
Journal of Biomedical Engineering 2001;18(2):206-209,213
RBC membrane shear elastic modulus and membrane viscosity are two important indexes reflecting RBC membrane viscoelasticity. Their variation was investigated in this study after rabbits were radiated with l60Co. With a new ektacytometer, we measured the small deformation index (DId) and the half-time of deformation relaxation (t0.5) of RBC in flow field then we calculated RBC membrane shear elastic modulus and membrane viscosity. We found that the value of RBC membrane shear elastic modulus and membrane viscosity continuously increased from 0 to 16th day then continuously decreased and tended to be stable on 60th day or so. The reason may lie in the variation of proportion of new and old RBC in blood and variation of microconformation of RBC membrane after rabbits were radiated with 60Co.

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