Objective: To examine the association between school sports environment and exercise habits among college students, and to test the mediating role of weight management intention in the relationship, so as to provide empirical evidence for promoting exercise habit formation of college students. Methods: A multi stage cluster sampling survey was conducted from April 15 to May 15, 2025, among 2 687 undergraduates from 8 colleges in Beijing, Shandong, Henan, Shanxi and Guangxi Zhuang Autonomous Region in China. School Sports Environment Characteristics Questionnaire, Weight Management Behavioral Intention Questionnaire and College Students Exercise Habit Scale were used for evaluation. Pearson correlation analysis was applied to examine the correlations among the three variables. A structural equation model (SEM) was constructed using AMOS 26.0, and the mediating effect was tested using the Bootstrap method. Results: The score for school sports environment was (3.72±0.57), with scores of (3.68±0.61) for physical environment and (3.74±0.59) for social environment; the scores for weight management intention and the total exercise habit were (4.21±0.46) and (3.94±0.51). School sports environment was positively correlated with weight management intention ( r =0.56) and exercise habits ( r =0.57), and weight management intention was positively correlated with exercise habits ( r =0.71) (all P <0.01). The SEM showed that school sports environment exerted positive impact on weight management intention ( β =0.50) and exercise habits ( β =0.29), weight management intention had a significant positive path to exercise habits ( β =0.52) (all P <0.01). Weight management intention of college students played a partial mediating role in the association between school sports environment and exercise habits, with an indirect effect of 0.259, accounting for 47.01% of the total effect. Conclusions The school sports environment is positively correlated with college students exercise habits, and might indirectly facilitate habit cultivation by improving weight management intention. While optimizing the physical and social environments of school sports in colleges, colleges should place a strong emphasis on stimulating college students weight management intention to promote the formation of their exercise habits.

Objective To analyze the pharmacodynamic interaction of esketamine and propofol in hysteroscopic surgery by response surface method.Methods Forty-five patients underwent elective hystero-scopic surgery,aged 18.5-64.0 years,BMI 18.5-28.0 kg/m2,ASA physical status Ⅰ or Ⅱ.Compound propofol target control infusion of esketamine(0,0.1,0.2,0.3,0.4,0.5,0.6,0.7,and 0.8 μg/ml)with different plasma drug concentrations were selected to keep the plasma drug concentration of esketamine unchanged,and the plasma drug concentration of propofol was increased step by step.To evaluate body re-sponse caused by dilation of the cervix.A response surface model was used to analyze the pharmacodynamic interaction of esketamine and propofol.Results The three-dimensional response surface of esketamine(0.0-0.8 μg/ml)and propofol(1.0-7.0 μg/ml)showed that the two have an additive effect in sedation and inhibition of body activity reaction caused by dilated cervix.The median effective concentration(EC50)of esketamine was 0.61 μg/ml(95％CI 0.41-0.81 μg/ml),and the EC50 of propofol was 4.69 μg/ml(95％CI 3.17-6.21 μg/ml)when inhibits the body activity reaction caused by dilated cervix.Conclusion Response surface method can qualitatively and quantitatively analyze the pharmacodynamic interaction of es-ketamine and propofol.Esketamine and propofol have additive effects in inhibiting the body activity reaction caused by dilated cervix.

Objective To evaluate the clinical effect of ultrasound-guided percutaneous transhepatic cholangial drainage (PTCD) combined with endoscopic retrograde cholangio-pancreatography (ERCP) in treating malignant obstructive jaundice, and to discuss its technical points. Methods A total of ten cases with malignant biliary obstruction were enrolled in this study. After the failure of ERCP treatment, the patients had to be treated with ultrasound-guided PTCD immediately. The guide-wire was inserted into the duodenum through intrahepatic bile duct and common bile duct to connect with ERCP, which was followed by the biliary stent implantation or the removal of physical factors causing obstruction. The clinical results were analyzed. Results Technical success was obtained in all 10 cases. In the patients who underwent a successful guide-wire docking with ERCP the postoperative serum bilirubin was significantly decreased. The main complications were fever, elevation of amylase and transient bloody bile. Conclusion With the help of docking technique the combination use of ultrasound-guided PTCD and ERCP is a new tentative treatment for malignant obstructive jaundice after the failure of initial ERCP treatment. This technique carries promising value in clinical practice as it can significantly increase the success rate of ERCP.

Herb-glycosides are main active elements of Zhongcaoyao (Chinese traditional medicines, Chinese medical herbs). However, the herb-glycoside structures are not optimal active structure for the human bodies. After orally taken up, the herb-glycosides of Zhongcaoyao could be changed into other more active structures by the digestive system such as enzymes and intestinal microorganisms; then degraded and absorbed in the human body and play the real role of pharmic effect; but only a small amount could be changed and controlled by circadian state of the human body. If this biochange of herb-glycosides to more active structures in vivo was finished in vitro, it is very useful for the development of the Chinese traditional medicines, new plant medicines, health food, and function cosmetics. To biotransformate herb-glycosides to more active structure, this paper introduced the studies of author's team on the new microorganism isolation of the special herb-glycosidases and enzyme fermentation, the special enzyme purification and characterization.
Bacteria ; enzymology ; metabolism ; Drugs, Chinese Herbal ; chemistry ; Fermentation ; Ginsenosides ; metabolism ; Glycoside Hydrolases ; metabolism ; Glycosides ; isolation & purification ; metabolism ; Saponins ; metabolism