OBJECTIVE: To explore the rules of acupoint selection and compatibility of acupuncture and moxibustion in treatment of chronic cough using data mining. METHODS: The ancient and modern medical record cloud platform, and the databases, i.e. CNKI, Wanfang, VIP, EMbase, Web of Science and PubMed, were searched to screen the ancient and modern literature on acupuncture and moxibustion treatment of chronic cough. The prescription database was established for acupuncture and moxibustion treatment of chronic cough, and the analysis conducted on the frequency and use percentage in the aspects of intervention measures, acupoint selection, acupoint distribution, meridian tropism, special points and acupoint combination, as well as the association rules and clustering rules of acupoint selection. The subgroup analysis was performed in accordance with the etiology of chronic cough and intervention measures. RESULTS: A total of 106 articles were included and 158 prescriptions were extracted. The intervention measures were acupuncture, moxibustion, herbal medication and the combination of several measures. The high-frequency acupoints included Feishu (BL13), Zusanli (ST36), Dazhui (GV14), Pishu (BL20), Danzhong (CV17), Shenshu (BL23), Lieque (LU7), Dingchuan (EX-B1), Tiantu (CV22), and Fenglong (ST40). These acupoints are mainly distributed on the back, lumbar region, chest and abdomen. The involved meridians were bladder meridian of foot-taiyang, conception vessel, and lung meridian of hand-taiyin. The special points covered back-shu points, crossing points and five-shu point. Regarding the compatibility of acupoints, the combination of upper and lower points, and the combination of front and back points were predominant in treatment. The analysis of association rules found that the support of Feishu (BL13)→Zusanli (ST36) was the highest; the cluster analysis obtained 8 clusters of acupoints. The acupoint compatibility and overall rules were similar when cough variant asthma (CVA) or the mixed reasons were involved, and the local treatment approach was adopted if the etiology of disease was related to upper airway cough syndrome (UACS) and gastroesophageal reflux cough (GERC). The acupoint selection was similar among different intervention measures. When two kinds of measures were combined in treatment, Feishu (BL13), Pishu (BL20) and Zusanli (ST36) were the most common. CONCLUSION In treatment with acupuncture and moxibustion for chronic cough, the acupoints are selected on the affected local area, depending on syndrome differentiation, and focusing on back-shu points. The main acupoints are Feishu (BL13), Zusanli (ST36), Dazhui (GV14), Pishu (BL20), Danzhong (CV17) and Shenshu (BL23). The combined therapy is dominant with acupuncture, moxibustion and herbal medicine involved.
Acupuncture Points ; Moxibustion/history* ; Humans ; Cough/history* ; Acupuncture Therapy/history* ; Chronic Disease/therapy* ; Data Mining ; History, Ancient ; Meridians ; Chronic Cough

OBJECTIVES: To investigate the expression of apolipoprotein C1 (APOC1) in papillary thyroid carcinoma (PTC) and its effects on proliferation and apoptosis of PTC cells. METHODS: The expression level of APOC1 in PTC and its impact on prognosis were analyzed using GEPIA 2 and Kaplan-Meier databases. Immunohistochemistry (IHC) and Western blotting were used to detect the expression of APOC1 in PTC and adjacent tissues and in 3 PTC cell lines and normal thyroid Nthyori 3-1 cells. In TPC-1 and BCPAP cells, the effect of Lipofectamine 2000-mediated transfection with APOC1 siRNA or an APOC1-overexpressing plasmid on cell growth and colony formation ability were examined by observing the growth curves and using colony-forming assay. The changes in cell cycle and apoptosis of the transfected cells were analyzed with flow cytometry. RT-qPCR and Western blotting were used to detect the changes in expressions of P21, P27, CDK4, cyclin D1, Bcl-2, Bax, caspase-3 and caspase-9 and the key proteins in the JAK2/STAT3 signaling pathway. RESULTS: APOC1 expression was significantly higher in PTC tissues and the 3 PTC cell lines than in the adjacent tissues and Nthyori 3-1 cells, respectively. In TPC-1 and BCPAP cells, APOC1 knockdown obviously reduced cell proliferative activity, increased the percentage of G0/G1 phase cells, lowered the percentages of S and G2 phase cells, promoted cell apoptosis, and downregulated mRNA and protein expression levels of CDK4, cyclin D1 and Bcl-2 and the protein levels of p-JAK2 and p-STAT3. APOC1 overexpression in the cells produced the opposite effects on cell proliferation, apoptosis, cell cycle and the mRNA and protein expressions. The application of AG490, a JAK2 inhibitor, strongly attenuated APOC1 overexpression-induced activation of the JAK2/STAT3 signaling pathway in BCPAP cells. CONCLUSIONS APOC1 overexpression promotes proliferation and inhibits apoptosis of PTC cells possibly by activating the JAK2/STAT3 signaling pathway and accelerating cell cycle progression.
Humans ; Apoptosis ; Cell Proliferation ; STAT3 Transcription Factor/metabolism* ; Signal Transduction ; Janus Kinase 2/metabolism* ; Thyroid Neoplasms/pathology* ; Thyroid Cancer, Papillary ; Cell Line, Tumor ; Carcinoma, Papillary

Objective To clarify the bottlenecks in the technology transfer work of public hospitals in China,and try to propose work optimization strategies and suggestions from the perspectives of different stakeholders.Methods The relevant literature about the transformation of scientific and technological achievements in public hospitals was searched on CNKI,and inductively summarize the relevant concepts and categories through the three stages of grounded theory coding.Results Through the three stages of coding,85 initial concepts,29 categories,and 5 main categories were sorted out,and a model attributing the influencing factors of the transformation of scientific and technological achievements in public hospitals was constructed,involving five major entities:public hospitals,medi-cal staff,enterprises,government,and universities.Conclusion The work of transforming scientific and technologi-cal achievements in public hospitals involves multiple stakeholders.It can start from the standardized management of public hospitals,the technological breakthroughs of medical staff,the active leadership of the government,the pro-active integration of enterprises,and the talent cultivation of universities to achieve innovation in talent cultivation mechanisms,industry evaluation mechanisms,profit distribution mechanisms,and intelligent management mecha-nisms.

Objective Understanding the cognitive attitude,influencing factors,and demand elements of medical staff in public hospitals towards the transformation of scientific and technological achievements,and proposing coun-termeasures and suggestions to improve the transformation rate of scientific and technological achievements in pub-lic hospitals.Methods Based on a questionnaire survey of the cognition and needs for the transformation of scientific and technological achievements among medical staff in public hospitals,it investigates medical personnel from 12 public hospitals in Anhui Province.Data processing is conducted using descriptive analysis and moderated mediation effect analysis methods.Results The cognitive attitude is positively correlated with influencing factors(r=0.125,P＜0.01),the degree of cognition is positively correlated with demand elements(r=0.599,P＜0.01),and influencing factors are positively correlated with demand elements(r=0.336,P＜0.01).The impact factors of medical staff in the process of scientific and technological achievement transformation play a partial mediating role between cognitive attitude and demand elements,and the technical title of medical staff has a moderating effect.Conclusion There are bottlenecks in the transformation of scientific and technological achievements by medical staff in public hospitals,in-cluding a weak awareness of transformation,limited transformation capabilities,disconnection between scientific re-search achievements and the market,and an unobvious collaborative effect of"government,education,medical care,production,and research".Public hospitals should improve supporting measures in aspects such as talent cultivation,management systems,professional training,and information construction.

Objective To evaluate the transformation of scientific and technological achievements in 12 affiliated hospitals of a medical university in Anhui Province,and to provide suggestions for the transformation of scientific and technological achievements in affiliated hospitals of colleges and universities.Methods According to the collected data,entropy weight method was used to assign weights to the index system,and TOPSIS method and rank sum ratio method were used for comprehensive evaluation.Results Among theevaluation indicators,the top 3 weights are the total amount of incoming accounts converted by self-implementation(4.801%),the total amount of incoming accounts earned by cooperating with others(4.801%),and the number of R&D institutions,transfer institutions,and conversion service platforms jointly built with affiliated universities(4.779%).In the fuzzy joint results,the top three hospitals were A,C and G,and the bottom three hospitals were K,H and E.There are obvious differences among hospitals,and there are differences between directly affiliated hospitals and non-directly affiliated hospitals.Conclusion The affiliated hospitals of colleges and universities should explore a development path of the transformation of scientific and technological achievements with their own characteristics and make the transformation from the actual situation.Transform the achievements into the discipline construction,deepen and expand the scientific research advantages;construct transformation consciousness raising system,and promote action with consciousness raising;colleges and universities lead the integration of medical industry to build a new ecology of medical production,study and research.

Objective To clarify the bottlenecks in the technology transfer work of public hospitals in China,and try to propose work optimization strategies and suggestions from the perspectives of different stakeholders.Methods The relevant literature about the transformation of scientific and technological achievements in public hospitals was searched on CNKI,and inductively summarize the relevant concepts and categories through the three stages of grounded theory coding.Results Through the three stages of coding,85 initial concepts,29 categories,and 5 main categories were sorted out,and a model attributing the influencing factors of the transformation of scientific and technological achievements in public hospitals was constructed,involving five major entities:public hospitals,medi-cal staff,enterprises,government,and universities.Conclusion The work of transforming scientific and technologi-cal achievements in public hospitals involves multiple stakeholders.It can start from the standardized management of public hospitals,the technological breakthroughs of medical staff,the active leadership of the government,the pro-active integration of enterprises,and the talent cultivation of universities to achieve innovation in talent cultivation mechanisms,industry evaluation mechanisms,profit distribution mechanisms,and intelligent management mecha-nisms.

Objective Understanding the cognitive attitude,influencing factors,and demand elements of medical staff in public hospitals towards the transformation of scientific and technological achievements,and proposing coun-termeasures and suggestions to improve the transformation rate of scientific and technological achievements in pub-lic hospitals.Methods Based on a questionnaire survey of the cognition and needs for the transformation of scientific and technological achievements among medical staff in public hospitals,it investigates medical personnel from 12 public hospitals in Anhui Province.Data processing is conducted using descriptive analysis and moderated mediation effect analysis methods.Results The cognitive attitude is positively correlated with influencing factors(r=0.125,P＜0.01),the degree of cognition is positively correlated with demand elements(r=0.599,P＜0.01),and influencing factors are positively correlated with demand elements(r=0.336,P＜0.01).The impact factors of medical staff in the process of scientific and technological achievement transformation play a partial mediating role between cognitive attitude and demand elements,and the technical title of medical staff has a moderating effect.Conclusion There are bottlenecks in the transformation of scientific and technological achievements by medical staff in public hospitals,in-cluding a weak awareness of transformation,limited transformation capabilities,disconnection between scientific re-search achievements and the market,and an unobvious collaborative effect of"government,education,medical care,production,and research".Public hospitals should improve supporting measures in aspects such as talent cultivation,management systems,professional training,and information construction.

Objective To evaluate the transformation of scientific and technological achievements in 12 affiliated hospitals of a medical university in Anhui Province,and to provide suggestions for the transformation of scientific and technological achievements in affiliated hospitals of colleges and universities.Methods According to the collected data,entropy weight method was used to assign weights to the index system,and TOPSIS method and rank sum ratio method were used for comprehensive evaluation.Results Among theevaluation indicators,the top 3 weights are the total amount of incoming accounts converted by self-implementation(4.801%),the total amount of incoming accounts earned by cooperating with others(4.801%),and the number of R&D institutions,transfer institutions,and conversion service platforms jointly built with affiliated universities(4.779%).In the fuzzy joint results,the top three hospitals were A,C and G,and the bottom three hospitals were K,H and E.There are obvious differences among hospitals,and there are differences between directly affiliated hospitals and non-directly affiliated hospitals.Conclusion The affiliated hospitals of colleges and universities should explore a development path of the transformation of scientific and technological achievements with their own characteristics and make the transformation from the actual situation.Transform the achievements into the discipline construction,deepen and expand the scientific research advantages;construct transformation consciousness raising system,and promote action with consciousness raising;colleges and universities lead the integration of medical industry to build a new ecology of medical production,study and research.

Objective To clarify the bottlenecks in the technology transfer work of public hospitals in China,and try to propose work optimization strategies and suggestions from the perspectives of different stakeholders.Methods The relevant literature about the transformation of scientific and technological achievements in public hospitals was searched on CNKI,and inductively summarize the relevant concepts and categories through the three stages of grounded theory coding.Results Through the three stages of coding,85 initial concepts,29 categories,and 5 main categories were sorted out,and a model attributing the influencing factors of the transformation of scientific and technological achievements in public hospitals was constructed,involving five major entities:public hospitals,medi-cal staff,enterprises,government,and universities.Conclusion The work of transforming scientific and technologi-cal achievements in public hospitals involves multiple stakeholders.It can start from the standardized management of public hospitals,the technological breakthroughs of medical staff,the active leadership of the government,the pro-active integration of enterprises,and the talent cultivation of universities to achieve innovation in talent cultivation mechanisms,industry evaluation mechanisms,profit distribution mechanisms,and intelligent management mecha-nisms.

Objective Understanding the cognitive attitude,influencing factors,and demand elements of medical staff in public hospitals towards the transformation of scientific and technological achievements,and proposing coun-termeasures and suggestions to improve the transformation rate of scientific and technological achievements in pub-lic hospitals.Methods Based on a questionnaire survey of the cognition and needs for the transformation of scientific and technological achievements among medical staff in public hospitals,it investigates medical personnel from 12 public hospitals in Anhui Province.Data processing is conducted using descriptive analysis and moderated mediation effect analysis methods.Results The cognitive attitude is positively correlated with influencing factors(r=0.125,P＜0.01),the degree of cognition is positively correlated with demand elements(r=0.599,P＜0.01),and influencing factors are positively correlated with demand elements(r=0.336,P＜0.01).The impact factors of medical staff in the process of scientific and technological achievement transformation play a partial mediating role between cognitive attitude and demand elements,and the technical title of medical staff has a moderating effect.Conclusion There are bottlenecks in the transformation of scientific and technological achievements by medical staff in public hospitals,in-cluding a weak awareness of transformation,limited transformation capabilities,disconnection between scientific re-search achievements and the market,and an unobvious collaborative effect of"government,education,medical care,production,and research".Public hospitals should improve supporting measures in aspects such as talent cultivation,management systems,professional training,and information construction.