Objective To investigate the relationship of neutrophil to lymphocyte ratio (NLR) and homocysteine (Hcy) with risk of coronary artery lesion progression in patients with hypertension. Methods The data of 306 patients with hypertension who received coronary angiography from January 2020 to January 2025 were included for retrospective investigation. The patients were divided into a non-progression group (175 cases) and a progression group (131 cases) based on the 6-month Gensini progression rate. The relationship between NLR and Hcy and coronary artery lesion progression was analyzed. Results Binary logistic regression analysis was applied to control confounding factors. After adjusting for confounding factors using Model1, Model2, and Model3, it was found that NLR and Hcy at admission were independently associated with the progression of coronary artery lesion in hypertensive patients [adjusted OR (95% CI) = 1.77 (1.48-2.11), 4.26 (2.71-6.69), P<0.001]. Receiver operating characteristic (ROC) curve revealed that the area under the curve of the combination of Hcy and NLR was 0.814 in predicting the progression of coronary artery lesion in hypertensive patients, which was higher than that of Hcy or NLR (Z/P=5.328, 2.077/<0.05). Conclusion Cardiovascular disease risk factors NLR and Hcy are independently associated with coronary artery lesion progression in patients with hypertension. Early detection of NLR and Hcy is helpful to predict the progression of coronary artery lesion.

Objective To evaluate the effect of different operation methods on the early swallowing function in the patients with laryngocarcinoma.Methods A total of 138 patients with the first time of open laryngectomy in this hospital from January 2021 to December 2022 were selected as the research subjects by convenience sampling method.The patients were divided into the vertical laryngeal resection group(vertical group,n=34),horizontal laryngeal partial resection(horizontal group,26 cases),suprachloroid laryngeal par-tial resection annular hyoid epiglottis fixation group(SCPL-CHEP group,n=26)and total laryngeal resection group(total laryngeal group,n=52)according to the operation methods.The Anderson Dysphagia Scale,Syd-ney Dysphagia Scale and modified swale drinking water test were used to evaluate the swallowing function on the first day of postoperative oral feeding in the patients.Results The total scores and scores of various di-mensions of the Chinese version of Anderson Dysphagia Scale,total scores and scores of various dimensions of Sydney Swallowing Scale and the results of the modified swale drinking water test had statistical differences a-mong the various groups(P＜0.01);the above indexes had statistical difference between the total laryngeal group and the other groups(P＜0.01),but the above indexes had no statistical difference between the two groups in the horizontal group,vertical group and SCPL-CHEP group(P＞0.05).Conclusion In the patients with laryngeal cancer undergoing open laryngectomy,the dysphagia is less severe during early eating after to-tal laryngectomy,which has little impact on life.

Objective:To construct an inpatient-outpatient-home step swallowing rehabilitation training program for partial laryngectomy patients.Methods:From June 2022 to May 2023, a preliminary program for inpatient-outpatient-home step swallowing rehabilitation training for partial laryngectomy patients was developed through literature search and analysis. Delphi method was used for two rounds of expert inquiry on the inpatient-outpatient-home step swallowing rehabilitation training program for partial laryngectomy patients.Results:A total of 15 experts were included for two rounds of expert inquiry. The effective response rates of the questionnaires from the two rounds of expert inquiries were 100.0% (15/15). The expert authority coefficients for the two rounds of inquiry were 0.885 and 0.855, respectively, and the Kendall harmony coefficients were 0.217 and 0.230, respectively ( P<0.01). The final inpatient-outpatient-home step swallowing rehabilitation training program for partial laryngectomy patients included three primary items (swallowing training step, swallowing training methods, and feeding guidance methods), 21 secondary items, and 35 tertiary items. Conclusions:The inpatient-outpatient-home step swallowing rehabilitation training program for partial laryngectomy patients based on the Delphi method has certain scientific and feasibility and can provide a reference for medical and nursing staff.

Objective:To explore the effects of swallowing rehabilitation training on swallowing function and quality of life in patients after laryngectomy.Methods:Randomized controlled trials on the effects of swallowing rehabilitation training on swallowing function and quality of life in postoperative laryngeal cancer patients were electronically retrieved from the Cochrane Library, PubMed, Embase, Web of Science, CINAHL, China National Knowledge Infrastructure, WanFang Data, VIP, and China Biology Medicine disc. The search period was from database establishment to February 1, 2024. The quality evaluation criteria for randomized controlled trials of Joanna Briggs Institute Evidence-Based Health Care Center (2016) was used to evaluate the included literature. RevMan 5.3 software was used for meta-analysis.Results:A total of ten articles were included, with 987 patients. Meta-analysis showed that swallowing rehabilitation training could improve the swallowing function ( P<0.01) and quality of life ( P<0.01) of patients after laryngectomy. Conclusions:Swallowing rehabilitation training can improve patients' swallowing function and quality of life after laryngectomy and is worth applying in clinical practice.

Objective:To construct the nursing quality evaluation index system for Laryngeal Cancer Rehabilitation Nursing Clinic.Methods:The nursing quality evaluation index system for Laryngeal Cancer Rehabilitation Nursing Clinic was constructed through literature analysis and survey research. From October to December 2022, 17 experts were selected for two rounds of expert consultation, and indicators at all levels were screened, modified, and improved to establish the nursing quality evaluation index system for Laryngeal Cancer Rehabilitation Nursing Clinic.Results:In the two rounds of expert consultation, the effective response rate of the questionnaire was 100.0% (17/17), and the expert authority coefficients were 0.912 and 0.924, respectively. The Kendall harmony coefficients of the two rounds of consultation were 0.199 and 0.221, respectively ( P<0.05). The final constructed nursing quality evaluation index system for Laryngeal Cancer Rehabilitation Nursing Clinic included 3 primary indicators, 15 secondary indicators, and 90 tertiary indicators. Conclusions:The nursing quality evaluation index system for Laryngeal Cancer Rehabilitation Nursing Clinic is scientific and reliable, providing reference for nursing quality evaluation and standardized management of Laryngeal Cancer Rehabilitation Nursing Clinic.

Objective:To evaluate the effect of swallowing training on swallowing function and quality of life in patients with head and neck cancer after radiotherapy.Methods:Cochrane Library, CINAHL, PubMed, Embase, Web of Science, Sinomed, CNKI, Wanfang and VIP databases were searched by computer for randomized controlled trials related to effects of swallowing training on swallowing function and quality of life of patients with head and neck cancer after radiotherapy. The publication time of the literatures was from the establishment of the database to December 10, 2021.The first two authors of this article independently screened the literature, and the methodological quality of the literature was evaluated using the risk of bias assessment tool recommended by the Cochrane Quality Evaluation Manual 5.1.0. RevMan 5.3 software was used for data analysis of related indicators of swallowing function and quality of life.Results:Finally, 12 articles with a total of 701 patients were included. Meta-analysis of the effect of swallowing training on the swallowing function of patients with head and neck tumors after radiotherapy showed that swallowing training in patients with head and neck tumors after radiotherapy can effectively improve swallowing function: Kubota Water Swallowing Test ( RR=1.82, 95% CI: 1.51-2.19, P<0.000 01) , Videofluoroscopic Swallowing Study ( RR=1.91, 95% CI: 1.34-2.72, P=0.000 4) , Standardized Swallowing Assessment ( MD=-6.47, 95% CI: -8.42--4.52, P<0.000 01) , Functional Oral Intake Scale ( MD=1.50, 95% CI: 1.16-1.84, P<0.000 01) . Meta-analysis of the effect of swallowing training on the quality of life of patients with head and neck cancer after radiotherapy showed that there was heterogeneity among studies and the heterogeneity was high. Conclusions:Swallowing training can effectively improve the swallowing function of patients with head and neck cancer after radiotherapy, but whether the quality of life is improved still needs more evidence to further confirm.

Objective:To deeply understand the evaluation of allergic rhinitis patients on the use of health education accurately linking system, analyze their real experience and needs, so as to provide improvement basis for optimizing intelligent mobile education system.Methods:From January to June 2021, 15 patients with allergic rhinitis were selected from the Otolaryngology and Head and Neck Surgery of Beijing Tongren Hospital affiliated to Capital Medical University by purposive sampling as the interviewee. A total of 15 patients with allergic rhinitis were interviewed semi structurally, and the results were analyzed by thematic analysis.Results:The experience of the health education accurately linking system was refined into three themes, namely, the practicality of the health education content, the effectiveness of the health education form, and the shortcomings of the education content and form.Conclusions:Through the health education accurately linking system as the carrier, the system presents standardized health education knowledge as the core of clinical application interviews. It is necessary to increase access to health information. The content of propaganda and education can mainly be short videos. The disease knowledge module can be improved according to the severity of the disease, so as to improve the quality of health education and promote the occurrence of health behaviors.

Objective:To understand the current status of postoperative self-care ability and quality of life in patients with laryngeal neoplasms, the correlation between them and the influencing factors of quality of life, so as to provide guidance for clinical formulation of targeted nursing measures.Methods:Using the convenient sampling method, a total of 126 patients who underwent laryngectomy for the first time in Department of Otorhinolaryngology and Head and Neck Surgery in Beijing Tongren Hospital, Capital Medical University from January to December 2018 were selected as the research objects. The Exercise of Self-Care Agency Scale (ESCA) and University of Washington-Quality of Life (UW-QOL) scale were used to investigate them.Results:The total score of ESCA of 126 patients with laryngeal neoplasms after operation was (110.35±16.05) , and the total score of UW-QOL scale was (557.32±70.00) . The total score of ESCA and scores of all dimensions were positively correlated with the total score of UW-QOL ( P<0.01) . Education level and self-care ability were the influencing factors of postoperative quality of life of patients with laryngeal neoplasms ( P<0.01) , which could explain 72.6% of the total variation. Conclusions:Postoperative self-care ability of patients with laryngeal neoplasms is at a moderate level. And the better the self-care ability of patients, the higher the quality of life.

Objective:To evaluate the effect of aerosol inhalation and airway dripping for airway humidification of patients with tracheotomy, and explore airway humidification methods suitable for China's national conditions.Methods:The documents published from January 2010 to October 2020 in The Cochrane Library, PubMed, Embase, China National Knowledge Infrastructure (CNKI) , Wanfang Data and VIP were searched by computer, including randomized controlled trials (RCTs) on the application of aerosol inhalation and airway dripping as a method of airway humidification in patients with tracheotomy. Two researchers used the quality evaluation method of Cochrane Handbook (5.1.0.) to rigorously evaluate the quality of the documents and extract data, and conducted a meta-analysis of the documents that met the quality standards.Results:A total of12 RCTs were included, with a total of 1 010 patients. The results of meta-analysis showed that the sputum viscosity in the aerosol inhalation group was lower than that in the airway dripping group [ RR=0.29, 95% CI (0.21, 0.40) , P<0.01], the incidences of airway mucosal injury, irritating dry cough and lung infection also decreased [ RR=0.34, 95% CI (0.23, 0.51) , P<0.01; RR=0.24, 95% CI (0.16, 0.38) , P<0.01; RR=0.48, 95% CI (0.38, 0.61) , P<0.01], the airway humidification effect was better than that of the airway dripping group [ RR=0.1.34, 95% CI (1.23, 1.45) , P<0.01]. Conclusions:The application of aerosol inhalation to humidify the airway in patients with tracheotomy can significantly reduce the sputum viscosity, airway mucosal injury, irritating dry cough, and the lung infection, and achieve a good airway humidification effect.

Objective:To investigate the awareness and implementation of swallowing training for laryngectomy patients among nurses of Otolaryngology Department in ClassⅢ Grade A hospitals of China so as to provide a basis for standardizing the swallowing training for laryngectomy patients and training for nurses.Methods:From September 2019 to October 2019, this study selected 274 nurses of Otolaryngology Department from 46 hospitals in 26 provinces or cities of China as subjects by convenience sampling. All of nurses were investigated with the self-designed awareness of swallowing training for laryngectomy patients questionnaires among nurses of Otolaryngology Department. SPSS 19.0 was used for data analysis, and enumeration data were expressed as the frequency, percentage or constituent ratio.Results:A total of 274 questionnaires were sent out and 268 valid questionnaires were collected. Among 268 nurses, there were 4.10% (11/268) of them completely understood the swallowing function training knowledge. Departments with the swallowing function training standard for the laryngectomy patients accounted for 43.66% (117/268) . A total of 95.52% (256/268) of nurses thought that it was necessary to unify the swallowing function training standard for the laryngectomy patients, and 93.28% (250/268) of nurses agreed to carry out swallowing function taining for patients. However, there were only 30.22% (81/268) of nurses carrying out swallowing assessment by scales.Conclusions:In China, nurses of Otolaryngology Department in ClassⅢ Grade A hospitals have inadequate knowledge of swallowing function training for laryngectomy patients, and the swallowing function training lacks unified standard. Swallowing training and standardized nursing practice needs to be further improved.