Objective To investigate the characteristics and prognostic significance of immunological indexes in patients with hyper-calcemia in multiple myeloma(MM).Methods A retrospective analysis of 241 newly diagnosed multiple myeloma(NDMM)admitted to the Second Hospital of Lanzhou University from January 2017 to September 2024 was conducted to compare the differences of 19 immuno-logical indicators between hypercalcemia and non-hypercalcemia group and in patients with mild,moderate and severe hypercalcemia,so as to explore the influence and significance of immune mechanism on it.Results Compared with patients without hypercalcemia,patients with MM complicated with hypercalcemia had higher levels of serum IL-1β,IL-2,IL-4,IL-5,IL-6,IL-10,IL-12p70,IFN-α and IFN-γ,lower CD4+T lymphocyte ratio and CD4+/CD8+ratio,and statistically significant differences(P＜0.05).Comparative a-nalysis of immune indicators in patients with three different degrees of hypercalcemia revealed that as blood calcium concentration in-creased,the Treg ratio and CD4+/CD8+values gradually decreased,with statistically significant differences(P＜0.05).Conclusion The results of this study showed that the immunological indexes of hypercalcemia patients were more abnormal than patients without in MM,suggesting that patients in this group had more disturbed immune microenvironment,which not only provided new indicators for poor prognosis,but also provided reference for future individualized immunotherapy.

Objective To investigate the characteristics and prognostic significance of immunological indexes in patients with hyper-calcemia in multiple myeloma(MM).Methods A retrospective analysis of 241 newly diagnosed multiple myeloma(NDMM)admitted to the Second Hospital of Lanzhou University from January 2017 to September 2024 was conducted to compare the differences of 19 immuno-logical indicators between hypercalcemia and non-hypercalcemia group and in patients with mild,moderate and severe hypercalcemia,so as to explore the influence and significance of immune mechanism on it.Results Compared with patients without hypercalcemia,patients with MM complicated with hypercalcemia had higher levels of serum IL-1β,IL-2,IL-4,IL-5,IL-6,IL-10,IL-12p70,IFN-α and IFN-γ,lower CD4+T lymphocyte ratio and CD4+/CD8+ratio,and statistically significant differences(P＜0.05).Comparative a-nalysis of immune indicators in patients with three different degrees of hypercalcemia revealed that as blood calcium concentration in-creased,the Treg ratio and CD4+/CD8+values gradually decreased,with statistically significant differences(P＜0.05).Conclusion The results of this study showed that the immunological indexes of hypercalcemia patients were more abnormal than patients without in MM,suggesting that patients in this group had more disturbed immune microenvironment,which not only provided new indicators for poor prognosis,but also provided reference for future individualized immunotherapy.