Objective To explore the relationship between the levels of hepatic fibrosis markers and peripheral venous pressure(PVP)in patients with chronic heart failure(CHF),as well as their correlation with the risk of poor prognosis in these patients.Methods A retrospective study was conducted on 216 elderly CHF patients admitted in Department of Cardiology,Qingdao Sixth People's Hospital from June 2021 to December 2024.Based on the occurrence of adverse cardiovascular events during 1-year follow-up,the patients were divided into a poor prognosis group(94 cases)and a good prognosis group(122 cases).The levels of hepatic fibrosis markers and PVP at discharge were collected.Multivariate logistic regression analysis was applied to explore the independent association of the marker levels and PVP with risk of poor prognosis.Results The good prognosis group had significantly reduced PVP,and lower levels of NT-proBNP,hyaluronic acid,type Ⅲ procollagen(PCⅢ),laminin(LN),type Ⅳ collagen(CⅣ),and 7S domain of type Ⅳ collagen N-terminal propeptide(P4NP 7S)when compared with the poor prognosis group(P＜0.05,P＜0.01).PVP was positively correlated with P4NP 7S,hyaluronic acid,CⅣ,PCⅢ and LN(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that NT-proBNP,PVP,hyaluronic acid,CⅣ,and P4NP 7S were independent risk factors for poor prognosis in CHF patients(P＜0.05,P＜0.01).ROC curve analysis revealed that the AUC value of combined hepatic fibrosis markers and PVP in predicting poor prognosis in CHF patients was 0.946(95％CI:0.907～0.972).Conclusion The levels of hepatic fibrosis markers are closely correlated with PVP in CHF patients.Combination of P4NP 7S,hyaluronic acid,CⅣ,and PVP can be used to assess the risk of adverse cardiovascular events and predict the prognosis of CHF patients.

Objective To explore the relationship between the levels of hepatic fibrosis markers and peripheral venous pressure(PVP)in patients with chronic heart failure(CHF),as well as their correlation with the risk of poor prognosis in these patients.Methods A retrospective study was conducted on 216 elderly CHF patients admitted in Department of Cardiology,Qingdao Sixth People's Hospital from June 2021 to December 2024.Based on the occurrence of adverse cardiovascular events during 1-year follow-up,the patients were divided into a poor prognosis group(94 cases)and a good prognosis group(122 cases).The levels of hepatic fibrosis markers and PVP at discharge were collected.Multivariate logistic regression analysis was applied to explore the independent association of the marker levels and PVP with risk of poor prognosis.Results The good prognosis group had significantly reduced PVP,and lower levels of NT-proBNP,hyaluronic acid,type Ⅲ procollagen(PCⅢ),laminin(LN),type Ⅳ collagen(CⅣ),and 7S domain of type Ⅳ collagen N-terminal propeptide(P4NP 7S)when compared with the poor prognosis group(P＜0.05,P＜0.01).PVP was positively correlated with P4NP 7S,hyaluronic acid,CⅣ,PCⅢ and LN(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that NT-proBNP,PVP,hyaluronic acid,CⅣ,and P4NP 7S were independent risk factors for poor prognosis in CHF patients(P＜0.05,P＜0.01).ROC curve analysis revealed that the AUC value of combined hepatic fibrosis markers and PVP in predicting poor prognosis in CHF patients was 0.946(95％CI:0.907～0.972).Conclusion The levels of hepatic fibrosis markers are closely correlated with PVP in CHF patients.Combination of P4NP 7S,hyaluronic acid,CⅣ,and PVP can be used to assess the risk of adverse cardiovascular events and predict the prognosis of CHF patients.

Objective To investigate the hypoglycemic effects of Laminaria japonica (L. japonica) on diabetic model induced by alloxan in rats. Methods Sixty healthy female rats were used to establish diabetic models by injecting alloxan peritoneally, and L.japonica was applied as raw materials for potential marine drugs.The levels of fasting blood glucose (FBG) were detected by automatic blood glucose device. Enzyme linkedimmunoabsorbant assay was applied to determine the insulin level in serum. The shape and structure of isletcells were observed with histopathological staining, and the expression of superoxide dismutase (SOD) and inducible nitric oxide synthase (iNOS) in islet cells were detected by immunohistochemical technique. Results After the treatment, the levels of FBG of L.japonica treated group B [(9.37±1.70) mmol/LandC (9.18±1.65 ) mmol/L, F= 32.81, q=6.35～11.72, P<0.05 ] reduced, while the serum levels of insulin in treated group A, Band C (0.0378±0.0026, 0.0378±0.0027, 0.0367±0.0035) increased(F= 11.40, q=4.28～8.47, P<0.05) significantly than those of diabetic model group (0.0456 ±0.0057) . The shape and structure of islet cells improved with the up-expressing SOD(t=4.73～4.76, P<0.05)and down-expressing iNOS (t=4.81～5.30, P<0.05) in L.japonica treated group B and C than those in diabetic model group. Conclusion L.japonica might decrease the serum level of FBG through promoting the islet cell recovery by an anti-oxide effect.