1.ACTH-independent Cushing′s syndrome caused by a GNAS hotspot mutation: Case reports of two rare patients with McCune-Albright syndrome complicated by Cushing′s syndrome and literature review
Ziwei CHEN ; Congcong XIA ; Ning PAN ; Zhuozhou CUI ; Li JIANG ; Ni ZHEN ; Yuan XIAO ; Zhiya DONG ; Xiaoyu MA ; Wenli LU
Chinese Journal of Endocrinology and Metabolism 2025;41(6):497-504
McCune-Albright syndrome(MAS) is a postzygotic somatic mutation disorder caused by activating mutations in the GNAS gene, which encodes the α subunit of the stimulatory G protein. Its clinical features typically include polyostotic fibrous dysplasia, cafe-au-lait skin pigmentation, and endocrine hyperactivity, such as Cushing′s syndrome, hyperthyroidism, and growth hormone excess. Here, we report two rare cases of MAS complicated with adrenocorticotropic hormone(ACTH)-independent Cushing syndrome, and provide a review and analysis of previously reported MAS cases associated with Cushing′s syndrome.
2.ACTH-independent Cushing′s syndrome caused by a GNAS hotspot mutation: Case reports of two rare patients with McCune-Albright syndrome complicated by Cushing′s syndrome and literature review
Ziwei CHEN ; Congcong XIA ; Ning PAN ; Zhuozhou CUI ; Li JIANG ; Ni ZHEN ; Yuan XIAO ; Zhiya DONG ; Xiaoyu MA ; Wenli LU
Chinese Journal of Endocrinology and Metabolism 2025;41(6):497-504
McCune-Albright syndrome(MAS) is a postzygotic somatic mutation disorder caused by activating mutations in the GNAS gene, which encodes the α subunit of the stimulatory G protein. Its clinical features typically include polyostotic fibrous dysplasia, cafe-au-lait skin pigmentation, and endocrine hyperactivity, such as Cushing′s syndrome, hyperthyroidism, and growth hormone excess. Here, we report two rare cases of MAS complicated with adrenocorticotropic hormone(ACTH)-independent Cushing syndrome, and provide a review and analysis of previously reported MAS cases associated with Cushing′s syndrome.
3.Cleidocranial dysostosis-a family with three cases.
Cui MAO ; Yonghua LI ; Mingchao LI ; Guohong LIU ; Hongna SUO
Chinese Journal of Medical Genetics 2014;31(2):258-258
Adult
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Cleidocranial Dysplasia
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genetics
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pathology
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Female
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Humans
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Male
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Middle Aged
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