Objective: To investigate the epidemiological characteristics of lung cancer in cancer registration areas of Guangdong Province in 2020, so as to provide the evidence for improving prevention and control strategies of lung cancer. Methods: Data of incidence and mortality in 2020 from 30 cancer registries in Guangdong Province were collected from the Cancer Follow-up Registration System and the All-Cause Mortality Registration Reporting System of the Guangdong Provincial Center for Disease Control and Prevention. The crude incidence, crude mortality, and cumulative rate for 0 to 74 years were calculated. The Chinese population-standardized rate and world population-standardized rate were calculated using the age structure of the standard population from the Fifth National Population Census in 2000 and Segi's world standard population. The incidence and mortality characteristics of lung cancer in different genders, urban/rural areas and ages were described. Results: In 2020, there were 25 357 new cases of lung cancer in Guangdong Province. The crude incidence, Chinese population-standardized incidence, world population-standardized incidence, and cumulative incidence for 0 to 74 years were 60.40/100 000, 43.75/100 000, 43.26/100 000, and 5.30%, respectively. There were 14 366 lung cancer deaths. The crude mortality, Chinese population-standardized mortality, world population-standardized mortality, and cumulative mortality for 0 to 74 years were 38.82/100 000, 24.49/100 000, 24.36/100 000, and 2.88%, respectively. The crude incidence and crude mortality of lung cancer in males were higher than those in females (71.19/100 000 vs. 49.42/100 000, 52.94/100 000 vs. 24.36/100 000, both P<0.05). The crude incidence and crude mortality of lung cancer in urban areas were higher than those in rural areas (66.37/100 000 vs. 45.95/100 000, 40.68/100 000 vs. 35.07/100 000, both P<0.05). The crude incidence and crude mortality of lung cancer exhibited upward trends with increasing age (both P<0.05), peaking in the age of 80-<85 years (347.97/100 000 and 342.14/100 000). Conclusions Comparing to the national data, the incidence of lung cancer in registration areas of Guangdong Province remained relatively high, while mortality remained relatively low. Males, urban residents and the elderly constitute the key populations for lung cancer prevention and control. It is recommend to optimize the allocation of medical resources between urban and rural areas and strengthen lung cancer screening among high-risk groups.

Objective To investigate the correlation of serum estradiol(E2),relaxin(RLX)levels and pelvic floor ultrasound parameters with the severity of postpartum stress urinary incontinence(PSUI)in patients.Methods A total of 144 patients with PSUI were enrolled in the PSUI group.According to the severity of the disease,they were divided into mild(n=59),moderate(n=55)and severe groups(n=30).Another 91 healthy postpartum women were selected as control group during the same period.General data of the PSUI group and the control group were compared.Serum E2 and RLX levels in patients with different severity levels were analyzed.Pelvic floor ultrasound parameters among groups were compared.Multivariate Logistic regression analysis was used to screen the influen-cing factors for the occurrence of PSUI.The correlations of serum E2,RLX levels and pelvic floor ul-trasound parameters with the severity of PSUI were analyzed.Results The serum RLX level in the PSUI group was significantly higher than that in the control group,while the E2 level was significantly lower(P＜0.05).The serum E2 level in the severe group was significantly lower than that in the moderate group and mild group,while the RLX level was significantly higher(P＜0.05).The proportions of multiple births,vaginal delivery,family history of urinary incontinence,mediolateral episiotomy and high serum RLX level as well as low serum E2 level in the PSUI group were significantly higher than those in the control group(P＜0.05).In the mild group,moderate group and severe group,the bladder-urethral posterior angle(PUA),urethral tilt angle(UTA),levator hiatus area as well as Valsalva maneuver-related urethral rotation angle(URA),bladder neck descent(BND)at rest and during maximum Valsalva maneuver increased sequentially(P＜0.05).In the mild group,moder-ate group,and severe group,the bladder position(BDP)and bladder neck position(BNP)during Valsalva maneuver decreased sequentially(P＜0.05).The funnel formation rate of the internal ure-thral orifice in the PSUI group and the control group were 22.22％(32/144)and 6.59％(6/91),respectively.Multivariate Logistic regression analysis showed that parity,vaginal delivery,family history of urinary incontinence,mediolateral episiotomy and serum E2 and RLX levels were influen-cing factors for the occurrence of PSUI(P＜0.05).Serum RLX levels and pelvic floor ultrasound parameters in PSUI patients were positively correlated with disease severity(r=0.573,0.590,P＜0.05),while serum E2 levels were negatively correlated with disease severity(r=-0.584,P＜0.001).Conclusion Serum E2 levels are negatively correlated with the severity of PSUI,while se-rum RLX levels and pelvic floor ultrasound parameters are positively correlated with the severity of PSUI.Parity,vaginal delivery,family history of urinary incontinence,mediolateral episiotomy and serum E2 and RLX levels are influencing factors for the occurrence of PSUI.