Objective:To observe the relationship between hemoglobin variability and serum albumin in maintenance hemodialysis (MHD) patients, and analyze the related factors.Methods:110 MHD patients who met the inclusion criteria in the hemodialysis center of Chancheng District Central Hospital of Foshan City were selected. The basic clinical data, biochemical indexes and hemoglobin variation related indexes were collected. The patients were divided into group 1 (normal albumin group ≥35 g/L) and groups 2 (low albumin group <35 g/L) according to serum albumin level.Results:⑴ Compared with group 1 (normal albumin group), the body mass index (BMI), serum creatinine and transferrin saturation in group 2 (low albumin group) were significantly decreased [(20.78±3.45)kg/m 2 vs (22.87±3.91)kg/m 2; (913.06±175.05)μmol/L vs (1 039.20±285.43)μmol/L; (24.83±14.36)% vs (30.39±10.38)%, P<0.05]. However, there was no significant difference in age, gender, dialysis age, intact parathyroid hormone (iPTH), high sensitivity C-reactive protein (hs-CRP), ferritin, erythropoietin dosage, iron supplement way, vascular access, urea nitrogen, kt/V between the 2 groups ( P>0.05). ⑵ Compared with group 1, the group 2 had lower mean hemoglobin value, fewer times of reaching the standard, lower hemoglobin minimum value and larger hemoglobin coefficient of variation ( P<0.05). There was no significant difference in hemoglobin standard deviation and maximum hemoglobin ( P>0.05). ⑶ Pearson correlation analysis showed that serum albumin was positively correlated with mean hemoglobin, times of reaching the standard and minimum hemoglobin ( r=0.401, 0.378, 0.200, P<0.05), and negatively correlated with coefficient of variation of hemoglobin ( r=-0.237, P=0.013). Conclusions:Maintenance hemodialysis patients with hypoalbuminemia have lower level of hemoglobin and greater coefficient of hemoglobin variability.Improving nutritional state maybe increase hemoglobin level and decrease coefficient of hemoglobin variability.

Sepsis has the characteristics of high morbidity and high mortality, which is the main cause of death in critically ill patients. Peripheral 5-hydroxytryptamine (5-HT) is mainly synthesized and secreted by enterochromaffin cells and plays a role in the development and progression of inflammation. This article focuses on 5-HT, 5-HT transporter (SERT) and selective serotonin reuptake inhibitors (SSRIs) in immune response, inflammatory factor release, oxidative stress, intestinal bacterial translocation and microcirculation of sepsis. The role of the review is to find new ideas for the clinical treatment of sepsis.