Objective To investigate the clinical effect of cefixime on the treatment for patients with acute bacterial enteritis and the influence on serum inflammatory factors .Methods A total of 92 cases with acute bacterial enteritis ,treated in our hospital from June 2015 to September 2016 ,were selected as the research object ,and randomly divided into cefixime group and cefaclor group , with 46 cases in each group .The cefixime group was given treatment of cefixime ,and cefaclor group was given treatment of cefa-clor ,for 5 to 7 consecutive days .Observation of clinical treatment effect was performed .Results On the first three days after treat-ment ,the number of diarrhea of cefixime group is lower than the one of cefaclor group ,and the difference was statistically significant (P<0 .05);after Day 3 of treatment ,the levels of CRP ,CER ,AAG ,IL-8 ,PCT ,TNF-alpha of cefixime group were lower than those of cefaclor group ,and the difference was statistically significant (P<0 .05);after Day 3 of treatment ,efficiency rate ,effective rate and invalid rate of cefixime group were 50 .0% ,47 .83% and 2 .17% ,respectively ;efficiency rate ,effective rate and invalid rate of cefaclor group were 32 .61% ,56 .52% and 10 .87% respectively ;the treatment effect of cefixime group is better than that of cefaclor group ,and the difference was statistically significant (P<0 .05) .Conclusion The clinical effects of cefixime on the treatment for patients with acute bacterial enteritis is better than that of cefaclor .