OBJECTIVE To evaluate the efficacy of sulbactam-durlobactam combined with meropenem in treating carbapenem-resistant Acinetobacter baumannii(CRAB)pulmonary infection.METHODS A total of 16 patients treated at China-Japan Friendship Hospital from Jan.1,2025 to Jun.1,2025 were included.Retrospective analy-sis was conducted on patients'basic situation,preliminary treatment regimens,infection-related diagnoses,etiolo-gy and clinical outcomes.Therapeutic drug monitoring(TDM)for sulbactam was also performed.RESULTS By the end of the treatment course,13 patients achieved etiological eradication of CRAB and clinical improvement,while 1 patient experienced CRAB recurrence within one month.Three patients showed treatment failure.TDM for sulbactam was performed in 13 patients.Except for one slightly lower,all achieved trough plasma concentra-tions above the minimum inhibitory concentration(MIC)(100％T＞MIC,MIC=4 mg/L based on clinical breakpoints).Dosage adjustments based on plasma concentrations were made for 4 patients,with 3 receiving re-duced doses and 1 receiving an increased dose.CONCLUSIONS Sulbactam-durlobactam combined with meropenem demonstrates superior efficacy in treating CRAB compared to other regimens.Under the recommended dosage,all patients can achieve the PK/PD target for sulbactam.

OBJECTIVE To evaluate the efficacy of sulbactam-durlobactam combined with meropenem in treating carbapenem-resistant Acinetobacter baumannii(CRAB)pulmonary infection.METHODS A total of 16 patients treated at China-Japan Friendship Hospital from Jan.1,2025 to Jun.1,2025 were included.Retrospective analy-sis was conducted on patients'basic situation,preliminary treatment regimens,infection-related diagnoses,etiolo-gy and clinical outcomes.Therapeutic drug monitoring(TDM)for sulbactam was also performed.RESULTS By the end of the treatment course,13 patients achieved etiological eradication of CRAB and clinical improvement,while 1 patient experienced CRAB recurrence within one month.Three patients showed treatment failure.TDM for sulbactam was performed in 13 patients.Except for one slightly lower,all achieved trough plasma concentra-tions above the minimum inhibitory concentration(MIC)(100％T＞MIC,MIC=4 mg/L based on clinical breakpoints).Dosage adjustments based on plasma concentrations were made for 4 patients,with 3 receiving re-duced doses and 1 receiving an increased dose.CONCLUSIONS Sulbactam-durlobactam combined with meropenem demonstrates superior efficacy in treating CRAB compared to other regimens.Under the recommended dosage,all patients can achieve the PK/PD target for sulbactam.

Objective:This study aims to analyze the clinical data of elderly patients who experienced respiratory failure after undergoing thoracoscopic-assisted radical lung cancer surgery.The objectives are to identify the risk factors associated with respiratory failure and to investigate the clinical significance of independent risk factors for the early prediction of respiratory failure in this patient population.Methods:A total of 42 elderly patients who developed respiratory failure following thoracoscopic-assisted radical lung cancer surgery at our hospital between January 1, 2021, and December 31, 2023, were continuously collected to form the observation group.Concurrently, a control group was established by randomly selecting elderly lung cancer patients who did not experience respiratory failure during the same period, in a 1: 1 ratio.Clinical data were collected from both groups, and logistic univariate and multivariate analyses were conducted.A receiver operating characteristic(ROC)curve was employed to evaluate the area under the curve(AUC), as well as the sensitivity and specificity of independent risk factors and their combinations.Results:The history of diabetes, PCT levels, and surgical day intake have been identified as independent risk factors for respiratory failure.Multivariate analysis revealed that a history of diabetes( OR: 1.29, 95% CI: 0.89-1.69; P=0.012), PCT( OR: 1.75, 95% CI: 1.51-2.38; P=0.005), and surgical day intake( OR: 1.42, 95% CI: 1.14-1.76; P<0.001)were significantly associated with the occurrence of postoperative respiratory failure.The area under the curve(AUC)values for predicting respiratory failure were 0.679, 0.679, and 0.740, respectively.The sensitivity and specificity for a history of diabetes were 41.2% and 87.1%; for PCT, 64.7% and 64.5%; and for surgical day intake, 70.6% and 74.2%.Notably, a combined model incorporating these three indicators produced an AUC of 0.918, with a sensitivity of 94.1% and a specificity of 80.6%. Conclusions:Following thoracoscopic-assisted radical lung cancer surgery, elderly patients with a history of diabetes, elevated PCT levels, and a daily fluid intake exceeding 2000 ml on the day of surgery demonstrate significant clinical value for the early detection of respiratory failure.

Objective:This study aims to analyze the clinical data of elderly patients who experienced respiratory failure after undergoing thoracoscopic-assisted radical lung cancer surgery.The objectives are to identify the risk factors associated with respiratory failure and to investigate the clinical significance of independent risk factors for the early prediction of respiratory failure in this patient population.Methods:A total of 42 elderly patients who developed respiratory failure following thoracoscopic-assisted radical lung cancer surgery at our hospital between January 1, 2021, and December 31, 2023, were continuously collected to form the observation group.Concurrently, a control group was established by randomly selecting elderly lung cancer patients who did not experience respiratory failure during the same period, in a 1: 1 ratio.Clinical data were collected from both groups, and logistic univariate and multivariate analyses were conducted.A receiver operating characteristic(ROC)curve was employed to evaluate the area under the curve(AUC), as well as the sensitivity and specificity of independent risk factors and their combinations.Results:The history of diabetes, PCT levels, and surgical day intake have been identified as independent risk factors for respiratory failure.Multivariate analysis revealed that a history of diabetes( OR: 1.29, 95% CI: 0.89-1.69; P=0.012), PCT( OR: 1.75, 95% CI: 1.51-2.38; P=0.005), and surgical day intake( OR: 1.42, 95% CI: 1.14-1.76; P<0.001)were significantly associated with the occurrence of postoperative respiratory failure.The area under the curve(AUC)values for predicting respiratory failure were 0.679, 0.679, and 0.740, respectively.The sensitivity and specificity for a history of diabetes were 41.2% and 87.1%; for PCT, 64.7% and 64.5%; and for surgical day intake, 70.6% and 74.2%.Notably, a combined model incorporating these three indicators produced an AUC of 0.918, with a sensitivity of 94.1% and a specificity of 80.6%. Conclusions:Following thoracoscopic-assisted radical lung cancer surgery, elderly patients with a history of diabetes, elevated PCT levels, and a daily fluid intake exceeding 2000 ml on the day of surgery demonstrate significant clinical value for the early detection of respiratory failure.