A total of 1 159 measles cases were reported in Zhuhai City from 2005 to 2022, with an average annual incidence rate of 4.21/10 5 (0-30.51/10 5). The M( Q1, Q3) age of the cases was 6.10 years old (10 months,23.20 years old), with the youngest cases being 2 months and the oldest age of 55 years old. The distribution of cases by age group was as follows: individuals aged18 years and older (34.94%), 8-23 months (22.95%), 2-6 years old (16.74%), 7-17 years old(12.86%) and infants under 8 months (12.51%), respectively. The primary groups affected by the disease included scattered children, workers, and students. The regional distribution exhibited distinct clustering characteristics in urban areas or streets with a high concentration of the migrant population. Following the initiation of Measles-containing Vaccine Supplementary Immunization Activities (MCV SIA) in 2009, the incidence of measles in Zhuhai City has significantly decreased, and there is no evident seasonal distribution of cases.

A total of 1 159 measles cases were reported in Zhuhai City from 2005 to 2022, with an average annual incidence rate of 4.21/10 5 (0-30.51/10 5). The M( Q1, Q3) age of the cases was 6.10 years old (10 months,23.20 years old), with the youngest cases being 2 months and the oldest age of 55 years old. The distribution of cases by age group was as follows: individuals aged18 years and older (34.94%), 8-23 months (22.95%), 2-6 years old (16.74%), 7-17 years old(12.86%) and infants under 8 months (12.51%), respectively. The primary groups affected by the disease included scattered children, workers, and students. The regional distribution exhibited distinct clustering characteristics in urban areas or streets with a high concentration of the migrant population. Following the initiation of Measles-containing Vaccine Supplementary Immunization Activities (MCV SIA) in 2009, the incidence of measles in Zhuhai City has significantly decreased, and there is no evident seasonal distribution of cases.

BACKGROUND: LY01005 (Goserelin acetate sustained-release microsphere injection) is a modified gonadotropin-releasing hormone (GnRH) agonist injected monthly. This phase III trial study aimed to evaluated the efficacy and safety of LY01005 in Chinese patients with prostate cancer. METHODS: We conducted a randomized controlled, open-label, non-inferiority trial across 49 sites in China. This study included 290 patients with prostate cancer who received either LY01005 or goserelin implants every 28 days for three injections. The primary efficacy endpoints were the percentage of patients with testosterone suppression ≤50 ng/dL at day 29 and the cumulative probability of testosterone ≤50 ng/dL from day 29 to 85. Non-inferiority was prespecified at a margin of -10%. Secondary endpoints included significant castration (≤20 ng/dL), testosterone surge within 72 h following repeated dosing, and changes in luteinizing hormone, follicle-stimulating hormone, and prostate specific antigen levels. RESULTS: On day 29, in the LY01005 and goserelin implant groups, testosterone concentrations fell below medical-castration levels in 99.3% (142/143) and 100% (140/140) of patients, respectively, with a difference of -0.7% (95% confidence interval [CI], -3.9% to 2.0%) between the two groups. The cumulative probabilities of maintaining castration from days 29 to 85 were 99.3% and 97.8%, respectively, with a between-group difference of 1.5% (95% CI, -1.3% to 4.4%). Both results met the criterion for non-inferiority. Secondary endpoints were similar between groups. Both treatments were well-tolerated. LY01005 was associated with fewer injection-site reactions than the goserelin implant (0% vs . 1.4% [2/145]). CONCLUSION: LY01005 is as effective as goserelin implants in reducing testosterone to castration levels, with a similar safety profile. TRIAL REGISTRATION ClinicalTrials.gov, NCT04563936.
Humans ; Male ; Antineoplastic Agents, Hormonal/therapeutic use* ; East Asian People ; Gonadotropin-Releasing Hormone/agonists* ; Goserelin/therapeutic use* ; Prostate-Specific Antigen ; Prostatic Neoplasms/drug therapy* ; Testosterone

【Objective】 To understand the effect of long-term high-frequency platelet donation on the health, safety and platelet quality of blood donors. 【Methods】 From August 2020 to July 2022, blood donors who donated platelets for single collection in the station were selected as two groups: those who donated for 20-29 times and those who donated for 30-44 times. Such 14 test indexes as red blood cell count (RBC), hemoglobin (Hb), hematocrit (Hct), mean corpuscular volume (MCV), platelet count (Plt), white blood cell count (WBC), large platelet ratio (P-LCR), lymphocyte (LYM) , neutrophil (NE), mean hemoglobin content (MCH), mean hemoglobin concentration (MCHC), platelet specific volume (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) were grouped and statistically analyzed for 5 times in each group. In addition, blood donors who have donated platelets more than 100 times in the station were chosen; the changes of their 5 parameters as RBC, Hb, Hct, PLT and WBC, as well as the correlation with the total number of platelet donations were analyzed through statistical analysis of the first 100 donations(10 donations/group). 【Results】 During 2 years, the hematological parameters were similar between 20-29 donation group(n=30) and 30-44 donation group(n=11) (P>0.05). For donors with donations≥100 occasions, RBC, Hb, Hct and WBC were negatively correlated with the number of blood donations, while Plt was positively correlated. There were significant differences in Hb, Hct, WBC and Plt among groups (P<0.05). Hb, Hct and WBC showed a downward trend, while Plt showed an upward trend. 【Conclusion】 With the increase of blood donations and units of blood donated, some changes in hematological parameters are observed among long-term high-frequency platelet donors. Monitoring and health education should be strengthened to ensure the safety and quality of blood donors.

Objective To evaluate the efficacy of one stage anterior debridement combined with posterior pedicle screw fixation in the treatment of cervical intervertebral space infection.Methods From June 2010 to June 2016,28 cases were fixed by anterior debridement combined with the posterior vertebral pedicle screws for the cervical intervertebral space infection,19 males and 9 females.The average age was 45-74 years (58±14.5 years old).21 cases (75％) were spontaneous infection,of which 6 cases were diabetes mellitus,15 cases were over 60 years old.The remaining 7 cases (25％) were intervertebral space infection after radiofrequency ablation of the cervical spine.All patients were excluded from tuberculosis and Brucella infection.All patients underwent hematological examination,with emphasis on WBC,ESP and CRP.All patients received JOA score before operation,applied antibiotic according to blood culture and drug sensitive test.All patients underwent one stage anterior debridement combined with posterior pedicle screw fixation,and the operative time and bleeding volume were recorded.After the operation,intravenous antibiotic therapy was continued,and the application of antibiotics was guided according to the results of ESP and CRP,and the time for the application of antibiotics was recorded.Follow up was performed at 3 months,6 months and 1 years after operation respectively.The JOA score and postoperative cervical lordosis Cobb angle were recorded.Results All operations were successfully completed in this group.The operation time was 130-225 min,with an average of 145.5±12.7 min.The intraoperative blood loss was 40-100 ml,with an average of 67±35.2 ml.The incision was healed in one stage.The time of application of antibiotics in 28 patients was 21-87 days,with an average of 30.8±8.7 days.The longest application time of antibiotics was 87 days,and no relapse was found during follow-up.The postoperative JOA score increased from 11.3± 1.2 to three months 14.9 ± 1.96 postoperatively and 6 months 15.1 ± 1.55 and 1 years 16.5±0.48 after operation.The JOA score was significantly higher than that before operation.No significant loss and change of the Cobb angle in the cervical spine surgery were found.All cases had good bone graft fusion at 1 years.Conclusion One stage anterior debridement combined with posterior pedicle screw fixation is a safe and effective method for the treatment of cervical vertebra instability and nerve function injury caused by cervical intervertebral space infection.It provides a new way for the treatment of cervical intervertebral space infection.

[Objective] Scoliosis with wedging of vertebra and open-up disc space over convex side can be reversed when PRSS(plate-rod system for scoliosis)was applied.In order to study the mechanical properties of the remedy for the scoliosis by PRSS,the photoelastic test was performed.[Method] The model that consists of five vertebra bodies and four intervertebral discs was built with aluminum and polycarbonate,thus the situation of low-grade scoliosis was simulated.The axial stress was loaded 0 kg,5kg,10 kg,15 kg,20 kg respectively,and the lateral side load was 0 kg,3 kg,6 kg,9 kg,and 12 kg respectively over the spinal column.According to the factual situation,the in-situ stress was measured by using photoelastic and strain gage method.ANSYS9.0 method was also applied to simulate the experiment process and evaluate the reliability of measurement.[Result]When PRSS was placed in,compressive stress was found to exert on the convex side whereas tensile stress was found on the concave side of the curvature,thus modulating bony growth of spinal vertebra,resulted in spinal column realignment.[Conclusion]The PRSS is an effective device to treat the scoliosis of the patients,especially in young children,because it not only can correct the deformity but also allows extension along with the children's growth.