Corn silk, a Traditional Chinese Medicine, has the effect of calming liver, cholagogue, detumescence and diuresis. Corn silk is also widely used as tea and functional food. Natural flavonoids have multiple biological activities, which are also the main bioactive components of corn silk. In the past decade, many new advances have been made in the chemistry, analysis, pharmacology, pharmacokinetics, and safety evaluation of corn silk flavonoids. The chemical composition research of flavonoids has enriched the variety of flavonoids in corn silk. Pharmacological studies have confirmed and expanded the efficacy of corn silk flavonoids. And safety evaluation has provided a theoretical basis for the safe application of corn silk flavonoids. Through literature search, the extraction, separation, compositional analysis, content determination, pharmacological effect, pharmacokinetics, and safety research progress of corn silk flavonoids in the past ten years were reviewed in this paper.

Objective To investigate the correlation between the expression of long non-coding RNA anti-differentiation non-coding RNA(lncRNA ANCR)and clinicopathological characteristics in nasopharyngeal carcinoma tissues.Methods A total of 115 patients pathologically diagnosed as naso-pharyngeal carcinoma in the hospital from June 2015 to June 2019 were randomly included as research objects,and real-time fluorescent quantitative PCR was used to detect the expression level of lncRNA ANCR in tumor tissues and adjacent normal tissues.Correlations of lncRNA ANCR expression with gender,age,pathological type,maximum diameter,differentiation grade,clinical stage,and lymph node metastasis were analyzed.Patients were followed up for 60 months to record tumor progression and overall survival.Results The expression level of lncRNA ANCR in tumor tissues was significant-ly higher than that in adjacent normal tissues(P＜0.001).Patients with a maximum diameter 3 cm,low differentiation,stage Ⅲ to Ⅳ,and positive lymph node metastasis had significantly higher lncRNA ANCR expression level in tumor tissues than those with a maximum diameter＜3 cm,moder-ate-to-high differentiation,stage Ⅰ to Ⅱ,and negative lymph node metastasis(P＜0.001).Patients with tumor progression and death outcome had significantly higher lncRNA ANCR expression level in tumor tissues than those without tumor progression and survival outcome(P＜0.001).Multivariate Logistic regression analysis showed that a maximum diameter ≥3 cm,stage Ⅲ to Ⅳ,positive lymph node metastasis,and lncRNA ANCR expression were significantly related to tumor progression,while stage Ⅲ to Ⅳ and lncRNA ANCR expression were significantly related to death(P＜0.001).The receiver operating characteristic(ROC)curve showed that the areas under the curve(AUC)for predicting tumor progression and death based on lncRNA ANCR expression level in tumor tissues were 0.899 and 0.842,respectively(P＜0.001).The Kaplan-Meier survival curve showed that the 5-year survival rate in the high lncRNA ANCR expression group was significantly lower than that in the low lncRNA ANCR expression group in tumor tissues(P＜0.01).Conclusion High ex-pression of lncRNA ANCR in tumor tissues may be involved in the malignant progression of nasopha-ryngeal carcinoma,and is closely related to clinical prognosis.

Objective: To assess the health risk associated with drinking water in Hangzhou from 2016 to 2017,and to provide evidence for the safety of drinking water . Methods: The monitoring data of 5 genetic toxic substances（arsenic,hexavalent chromium,cadmium,chloroform,tetrachloromethane）and 13 body toxic substances（lead,mercury,selenium,cyanide,fluoride,nitrate,iron,ammonia nitrogen,manganese,copper,zinc,aluminum,volatile phenol）from 36 source water samples,36 finished water samples and 288 tap water samples in the main urban areas of Hangzhou were collected from 2016 to 2017. The health risk of drinking water containing the chemical pollutants mentioned above were assessed based on the evaluation models recommended by United States Environmental Protection Agency . Results: The concentrations of 5 genetic toxic substances and 13 body toxic substances in source water,finished water and tap water were all within the reference limits issued by Standards for Drinking Water Quality（GB 5749—2006）. The carcinogenic risk,non-carcinogenic risk and total health risk caused by the chemical pollutants in the source water were 2.18×10-5/a,7.75×10-9/a and 2.18×10-5/a. The carcinogenic risk,non-carcinogenic risk and the total health risk caused by the chemical pollutants in the finished water were 1.08×10-5/a,3.70×10-9/a and 1.08×10-5/a. The carcinogenic risk,non-carcinogenic risk and total health risk caused by the chemical pollutants in the tap water were 1.96×10-5/a,3.61×10-9/a and 1.96×10-5/a. The carcinogenic risk and total health risk caused by chemical pollutants ranged from high to low in the source water,tap water and finished water. The non-carcinogenic risks ranged from high to low in the source water,finished water and tap water . Conclusion The health risks of 18 chemical pollutants in drinking water in Hangzhou were at a low level,with the greater carcinogenic risk than the non-carcinogenic risk. Hexavalent chromium had the highest carcinogenic risk,while fluoride and aluminum had the highest non-carcinogenic risk.

Rhinoscleroma disease accompanied with laryngotracheal stenosis as a main clinical manifestation is seldom. Here one case is reported. At the beginning, the patient had pharyngalgia and his swallowing was not smooth. After that, he had difficulty in breathing. Surgical therapy, antibiotics treatment and nutritional support were performed. The patient was cured.
Constriction, Pathologic ; Deglutition ; Humans ; Larynx ; physiopathology ; Male ; Respiration ; Rhinoscleroma ; complications ; diagnosis ; therapy ; Trachea ; physiopathology

OBJECTIVE: Understand the main types and characteristics of inhaled allergens in allergic rhinitis patients in Urumqi, Xinjiang, and provide theoretical basis for diagnosis, treatment, prevention of local allergic rhinitis and epidemiological investigation. METHOD: Inhaled allergen detecting on suspected patients with allergic rhinitis in clinic by the allergopharma skin prick test. Group the skin prick test positive patients of 340 samples according to their nationality, age and gender, then compare the inhaled allergen differences between them. RESULT: The total positive rate with allergic rhinitis prick test in 340 cases is 94.7%, of which the highest proportion is Artemisia (66.2%), followed by Chenopodium album (51.2%), poplar (42.6%), Ulmus (40.9%), Liu (33.8%), Timothy (27.6%), dust mite (21.2%), house dust mite (17.9%), ragweed (15.9%), dog (11.2%), cat (10.6%), cockroach (8.5%), Alternaria (5.6%) and Candida albicans (3.5%). The sensitivity of poplar, willow, Timothy and Alternaria of the minority group is higher than the Han group (P<0.05). The allergen positive rate difference among different age group has statistical significance (Χ2=59.076, P<0.01). CONCLUSION Artemisia, Chenopodiaceae, poplar and elm are the main allergens in Urumqi area. There is a difference in allergen sensitivity between Minority and Han nationality patients. There is no statistical significance on inhaled allergen positive rate between different genders. Specific allergens can provide basis for the prevention and control of allergic diseases in Urumqi area.
Allergens ; analysis ; Alternaria ; Animals ; Cats ; Cockroaches ; Dermatophagoides pteronyssinus ; Dogs ; Ethnic Groups ; Humans ; Pollen ; Rhinitis, Allergic ; pathology ; Skin Tests