Objective To explore the methods for reducing the consumption of cleaning water and sterilization water in hospital disinfection supply centers.Methods The water-using equipment equipped in the disinfection supply center of a hospi-tal from December 2023 to December 2024 was selected as the research subject,and a water usage optimization plan based on to-tal productive maintenance(TPM)was implemented on the subject in the center for 6 months.The reduction rate of water con-sumption,equipment operation efficiency,cost-effectiveness of water conservation,process efficiency,as well as the participation and satisfaction of employees in the new strategy were compared before and after the intervention.Results After intervention,the total water consumption in the center was significantly reduced[(5 494.66±544.85)m3 vs.(4 652.35±702.22)m3],the time for cleaning equipment was shortened[(38.16±4.99)min vs.(47.58±1.39)min],the time for equipment sterilization[(36.84±1.83)min vs.(47.24±1.13)min].The failure rate of the cleaning equipment was lowered(0.00％vs.4.00％).The water cost was decreased[(12 423.88±1 319.74)yuan vs.(10 214.84±979.30)yuan].The total cleaning and sterili-zation time was significantly shortened[(2.45±0.27)h vs.(1.29±0.26)h,(P＜0.05)].The water consumption was re-duced by 4.68％,and the total rate of satisfaction and participation of employees was 92.3％.Conclusion The optimization scheme for cleaning water in disinfection supply centers based on TPM can effectively reduce water consumption,save water costs,improve the operational efficiency of equipment,process efficiency,and participation and satisfaction of employees.It is worthy of promotion and application in medical institutions.

Objective To explore the methods for reducing the consumption of cleaning water and sterilization water in hospital disinfection supply centers.Methods The water-using equipment equipped in the disinfection supply center of a hospi-tal from December 2023 to December 2024 was selected as the research subject,and a water usage optimization plan based on to-tal productive maintenance(TPM)was implemented on the subject in the center for 6 months.The reduction rate of water con-sumption,equipment operation efficiency,cost-effectiveness of water conservation,process efficiency,as well as the participation and satisfaction of employees in the new strategy were compared before and after the intervention.Results After intervention,the total water consumption in the center was significantly reduced[(5 494.66±544.85)m3 vs.(4 652.35±702.22)m3],the time for cleaning equipment was shortened[(38.16±4.99)min vs.(47.58±1.39)min],the time for equipment sterilization[(36.84±1.83)min vs.(47.24±1.13)min].The failure rate of the cleaning equipment was lowered(0.00％vs.4.00％).The water cost was decreased[(12 423.88±1 319.74)yuan vs.(10 214.84±979.30)yuan].The total cleaning and sterili-zation time was significantly shortened[(2.45±0.27)h vs.(1.29±0.26)h,(P＜0.05)].The water consumption was re-duced by 4.68％,and the total rate of satisfaction and participation of employees was 92.3％.Conclusion The optimization scheme for cleaning water in disinfection supply centers based on TPM can effectively reduce water consumption,save water costs,improve the operational efficiency of equipment,process efficiency,and participation and satisfaction of employees.It is worthy of promotion and application in medical institutions.

Purpose To investigate the relationship be-tween the expressions of CD3,CD4,CD8,CD20,CD68,PD-1 and PD-L1 and the clinical prognosis of peritoneal mesothelioma(PM).Methods Clinical data of 69 PM patients were collect-ed.EnVision two-step immunohistochemical method was used to detect the expression of CD3,CD4,CD8,CD20,CD68,PD-1 and PD-L1 in PM.Associations between expression levels and survival were estimated by univariate and multivariate Cox pro-portional-hazards models.Results There were no significant differences in the expressions of CD3,CD4,CD8,CD20,CD68,and PD-1 in tumor infiltrating lymphocytes(TILs)of ep-ithelioid and non-epithelioid PM.The expression of PD-L1 in non-epithelioid PM TILs was higher than that in epithelioid PM TILs,but the difference was not statistically significant.The median overall survival(mOS)time of PM was 19.1 months.Multivariate models identified asbestos exposure(P=0.002),PCI score(P=0.034),histological type(P=0.036),and CD4 expression(P=0.043)was independent prognostic factors for PM.Conclusion Asbestos exposure,PCI score,histologi-cal type and CD4 expression in TILs may exert significant im-pacts on survival of PM patients.