Objective:To summarize the clinical characteristics, diagnostic and therapeutic approaches, and prognosis of posttransplant lymphoproliferative disease (PTLD) following kidney transplantation.Methods:A retrospective case series analysis was conducted on 7 PTLD patients after kidney transplantation treated in the Department of Transplant Oncology, Tianjin First Central Hospital between January 2018 and December 2023. Clinical features, laboratory findings, imaging and pathological characteristics, treatment modalities, and outcomes were analyzed.Results:Among 7 PTLD patients, there were 5 male and 2 females with a median age of 41 (17-65) years. The median time of onset after operation was 4 (0.5-11) years. Among them, 2 patients had early onset (<1 year post-transplantation) and 5 patients had late onset (>1 year). The clinical manifestations included abdominal mass in 4 cases, anemia in 4 cases, fever in 3 cases, lymphadenopathy in 4 cases, gastrointestinal bleeding in 1 case, abdominal pain in 2 cases, and intestinal obstruction in 2 cases. Pathological types included diffuse large B-cell lymphoma in 4 cases, Burkitt lymphoma in 1 case, marginal zone lymphoma in 1 case, and polymorphic PTLD in 1 case. Reducing the immunosuppressant level was the basal treatment plan, and rituximab, chemotherapy, surgery, radiotherapy and CD19-targeted chimeric antigen receptor therapy were given according to the pathological classification. Until the date of submission, 2 patients had died, 4 had a complete response, and 1 had a partial response. None of the patients had acute rejection, and 1 patient had chronic renal insufficiency.Conclusions:PTLD after kidney transplantation presents with nonspecific manifestations, necessitating prompt imaging and histopathological evaluation for definitive diagnosis. At the same time, a series of measures should be given to improve the prognosis, including discontinuous use of anti-metabolic drugs, dosage decline of calcitric phosphatase inhibitor by 50% or convert it to sirolimus treatment, and corresponding treatment according to the specific conditions of the recipient.

Objective:To summarize the clinical characteristics, diagnostic and therapeutic approaches, and prognosis of posttransplant lymphoproliferative disease (PTLD) following kidney transplantation.Methods:A retrospective case series analysis was conducted on 7 PTLD patients after kidney transplantation treated in the Department of Transplant Oncology, Tianjin First Central Hospital between January 2018 and December 2023. Clinical features, laboratory findings, imaging and pathological characteristics, treatment modalities, and outcomes were analyzed.Results:Among 7 PTLD patients, there were 5 male and 2 females with a median age of 41 (17-65) years. The median time of onset after operation was 4 (0.5-11) years. Among them, 2 patients had early onset (<1 year post-transplantation) and 5 patients had late onset (>1 year). The clinical manifestations included abdominal mass in 4 cases, anemia in 4 cases, fever in 3 cases, lymphadenopathy in 4 cases, gastrointestinal bleeding in 1 case, abdominal pain in 2 cases, and intestinal obstruction in 2 cases. Pathological types included diffuse large B-cell lymphoma in 4 cases, Burkitt lymphoma in 1 case, marginal zone lymphoma in 1 case, and polymorphic PTLD in 1 case. Reducing the immunosuppressant level was the basal treatment plan, and rituximab, chemotherapy, surgery, radiotherapy and CD19-targeted chimeric antigen receptor therapy were given according to the pathological classification. Until the date of submission, 2 patients had died, 4 had a complete response, and 1 had a partial response. None of the patients had acute rejection, and 1 patient had chronic renal insufficiency.Conclusions:PTLD after kidney transplantation presents with nonspecific manifestations, necessitating prompt imaging and histopathological evaluation for definitive diagnosis. At the same time, a series of measures should be given to improve the prognosis, including discontinuous use of anti-metabolic drugs, dosage decline of calcitric phosphatase inhibitor by 50% or convert it to sirolimus treatment, and corresponding treatment according to the specific conditions of the recipient.

Objective:A gas chromatography analysis system for fatty acid compositions of hydrogenated palm glycerides was established to provide a reference for quality standards of hydrogenated palm glycerides.Methods:In this test,a DB-WAX(30 m ×0.53 mm,1.0 μm)strong polarity gas chromatographic column was employed with an injection volume of 1 μL and a split ratio of 120∶1.The initial column temperature was 70℃,sustained for 2 min,ramped up to 230 ℃ at a rate of 5 ℃ per minute,and maintained for 10 min,with the inlet temperature of 250 ℃ and the detector temperature of 250 ℃.Results:In this experiment,the gas chromatograph-ic method was established successfully to determine fatty acid compositions of hydrogenated palm glycerides.The validated results indicated that the method exhibited well-suited system applicability,specificity and precision,and the RSD(％)fulfilled the requirements.The limit of detection(LOD)and limit of quantification(LOQ)values of nine fatty acid methyl esters were defined,and fatty acid compositions of seven batches of samples were checked successfully.Conclusion:The GC methodology developed in this study is suitable for the analysis and determina-tion of fatty acid compositions in hydrogenated palm glycerides,which can serve as a reference for the quality control of this pharmaceutical excipient and the establishment of quality standards.

At present,there is a lack of basic theoretical framework in the naval physiological and psychological training in PLA,and relevant researches and practices have not been comprehensively carried out.Based on the instructional system design(ISD),the most classic model in the field of training,we reviewed the latest research results on training from five aspects:training needs assessment,training design,training development,training implementation and training evaluation,and put forward targeted suggestion for the research and practice of naval physiological and psychological training in PLA.The main purpose of this paper is to provide assistance for the construction of naval physiological and psychological training system in PLA.

Objective:To investigate subjective ranking of factors influencing life and work among submariners in long oceangoing voyage, and to make some exploratory analysis and classification of those factors.Methods:A total of 546 submariners who had taken part in long oceangoing voyage were investigated by the specially designed Questionnaire on the Influence of Various Factors in the Long Oceangoing Voyage of Submariners. The data were analyzed by SPSS 23.0 software. Results:During the long oceangoing voyage, the order of the factors influencing submariners′ life and work from high degree to low degree were as follows: submarine harmful gas, submarine noise, biorhythm disorder, worries about personal health, lack of information, monotonous life, temperature and humidity of post and rest cabin, difficulty in personal hygiene maintenance, worries about parents′ health, food problem, narrow space, pressures from operation on post and learning, seasickness, family economic pressure, limited personal development, effects of color and lighting, relationships with leaders and fellow crew members. These factors constituted two categories of factors: physical and chemical environment factors and psychosocial factors. The physical and chemical environmental factors included loud noise and high pollution, seasickness and visual discomfort, high temperature and humidity, self-hygiene problems and biorhythm disorder; and the psychosocial factors were health concerns, life pressure, monotonous life, interpersonal relationship pressure, and work pressure.Conclusion:The main factors that greatly affect submariners′ work and life in long oceangoing voyage are harmful gas, noise, biorhythm disorder, worries about personal health, lack of information, and monotonous life. Generally speaking, the influence of the physical and chemical environment factors is greater than that of the psychosocial factors, although the latter one cannot be neglected as a major factor. It is necessary to improve the working and living environment of submariners through some targeted work, e. g. optimizing submarine design and providing psychological function care, so as to reduce the influence of various factors on the life and work of submariners.

Objective:To investigate subjective ranking of factors influencing life and work among submariners in long oceangoing voyage, and to make some exploratory analysis and classification of those factors.Methods:A total of 546 submariners who had taken part in long oceangoing voyage were investigated by the specially designed Questionnaire on the Influence of Various Factors in the Long Oceangoing Voyage of Submariners. The data were analyzed by SPSS 23.0 software. Results:During the long oceangoing voyage, the order of the factors influencing submariners′ life and work from high degree to low degree were as follows: submarine harmful gas, submarine noise, biorhythm disorder, worries about personal health, lack of information, monotonous life, temperature and humidity of post and rest cabin, difficulty in personal hygiene maintenance, worries about parents′ health, food problem, narrow space, pressures from operation on post and learning, seasickness, family economic pressure, limited personal development, effects of color and lighting, relationships with leaders and fellow crew members. These factors constituted two categories of factors: physical and chemical environment factors and psychosocial factors. The physical and chemical environmental factors included loud noise and high pollution, seasickness and visual discomfort, high temperature and humidity, self-hygiene problems and biorhythm disorder; and the psychosocial factors were health concerns, life pressure, monotonous life, interpersonal relationship pressure, and work pressure.Conclusion:The main factors that greatly affect submariners′ work and life in long oceangoing voyage are harmful gas, noise, biorhythm disorder, worries about personal health, lack of information, and monotonous life. Generally speaking, the influence of the physical and chemical environment factors is greater than that of the psychosocial factors, although the latter one cannot be neglected as a major factor. It is necessary to improve the working and living environment of submariners through some targeted work, e. g. optimizing submarine design and providing psychological function care, so as to reduce the influence of various factors on the life and work of submariners.

Objective To investigate the mental health status,influential factors and mediating variables among the commissioned and non-commissioned personnel in a certain coast guard district.Methods An investigation was made among 539 commissioned and non-commissioned personnel by Psychological Health Inventory (PHI),Eysenck Personality Questionnaire (EPQ),Automatic Thinking Questionnaire (ATQ) and a self-designed general annoyance questionnaire,and analysis of influential factors was performed by Structural Equation Modeling (SEM).Results The personality factor of the military personnel in a certain coast guard district could by no means induce mental symptoms directly(path coefficient =0.058) (P =0.473).Mental symptoms could only be induced by general annoyance,such as work annoyance,life annoyance,interpersonal relationship annoyance,as well as by the mediating effects of negative automatic thinking (path coefficient =-0.395,-0.632) (P ＜ 0.001).General annoyance could directly result in mental symptoms (path coefficient =-0.204)(P ＜ 0.001) and could induce mental symptoms as well through the mediating effects of negative automatic thinking(path coefficient =-0.204) (P ＜ 0.001).Conclusion Negative automatic thinking was a mediating variable between personality and mental symptoms induced by general annoyance.

Objective To investigate the mental health status,influential factors and mediating variables among the commissioned and non-commissioned personnel in a certain coast guard district.Methods An investigation was made among 539 commissioned and non-commissioned personnel by Psychological Health Inventory (PHI),Eysenck Personality Questionnaire (EPQ),Automatic Thinking Questionnaire (ATQ) and a self-designed general annoyance questionnaire,and analysis of influential factors was performed by Structural Equation Modeling (SEM).Results The personality factor of the military personnel in a certain coast guard district could by no means induce mental symptoms directly(path coefficient =0.058) (P =0.473).Mental symptoms could only be induced by general annoyance,such as work annoyance,life annoyance,interpersonal relationship annoyance,as well as by the mediating effects of negative automatic thinking (path coefficient =-0.395,-0.632) (P ＜ 0.001).General annoyance could directly result in mental symptoms (path coefficient =-0.204)(P ＜ 0.001) and could induce mental symptoms as well through the mediating effects of negative automatic thinking(path coefficient =-0.204) (P ＜ 0.001).Conclusion Negative automatic thinking was a mediating variable between personality and mental symptoms induced by general annoyance.