OBJECTIVE:T o analyze the consumptive trend of anti-infection agents from January 1997 to April 2001 MET HODS:Visual FoxPro(VFP)and Excel were used to analyze the annual consumption and order of anti-infection agents during this period DDDs and daily-cost were caculated. RESULTS:The consumption of anti -infection agents increased year by year. The highest DDDs and the lowest daily-cost of two main classes of anti-infection agents were penicillin G and cefazolin. respectively. CONCLUSION: The consumptive trend of anti-infection agents is developing towards highly effective, safe and cheap ones. More attention should he paid to avoid abuse of anti-infection agents.

AIM: To compare the permeation enhancing characters of menthol and azone on the model drug of indomethacin and to study the enhancing effect when the two agents were used in combination. METHODS: The transdermal test was conduced on the penetration experiment apparatus of isolated skin. The cumulate penetrated amount, penetrating rate, stable flux and lag time were calculated upon the concentrations. RESULTS: After adding the penetration enhancer, the penetrating rate of indomethacin increased remarkably. It was 6.21 , 4.91 and 6.92 times of that of the controls respectively. When used in combination, the two penetration enhancers increased much more the penetrating rate than being used separately (P