Background Pneumoconiosis remains a critical occupational disease in China. As a major industrial province, Hebei historically faced severe challenges regarding this condition. The 1986 national epidemiological survey ranked Hebei sixth in reported pneumoconiosis cases nationwide. Objective To analyze 76 years of pneumoconiosis data (1949–2024) in Hebei Province to provide evidence-based support for prevention and control strategies. Methods Occupational pneumoconiosis cases diagnosed in Hebei from 1949 to 2024 were included. Five-year intervals were used to analyze incidence composition, dust exposure duration, age at first diagnosis, and age at death. A hybrid model, integrating autoregressive integrated moving average (ARIMA) with generalized regression neural network (GRNN), was employed to predict case numbers for the 2025−2030 period. Results A total of 36107 cases of pneumoconiosis were recorded (2.10% female) in Hebei from 1949 to 2024. Stages I, II, and III accounted for 77.35%, 16.45%, and 6.20%, respectively. Silicosis (55.60%), coal workers’ pneumoconiosis (27.24%), and pottery workers’ pneumoconiosis (8.88%) were the predominant types. Observed trends included a shortened dust exposure duration [silicosis: (12.78±7.063) years in 2020–2024] and an increasing age at first diagnosis [(54.01±7.499) years in 2020–2024]. The case-fatality rate was 14.84%, with a rising age at death [(82.26±9.632) years in 2015–2019]. Three incidence peaks (1963, 1984, and 2014) correlated with national policies and industrialization phases. The number of pneumoconiosis cases showed a decreasing trend from 2015 to 2024. Chengde and Tangshan were identified as current high-risk areas. The ARIMA-GRNN model projected annual cases between 416 and 429 during 2025–2030. Conclusion In the past decade，the number of pneumoconiosis cases in Hebei Province had shown a decreasing trend, it is projected to plateau with no significant decline over the next five years. Furthermore, challenges such as the proportion of silicosis remaining high and shortened dust exposure duration remain severe. It is recommended to focus on key regions like Chengde (ore mining) and Tangshan (ceramics industry). A comprehensive strategy integrating stricter regulation, technological controls, model innovation, and targeted interventions should be implemented to achieve a further substantial reduction in pneumoconiosis incidence.

Background Pneumoconiosis remains a critical occupational disease in China. As a major industrial province, Hebei historically faced severe challenges regarding this condition. The 1986 national epidemiological survey ranked Hebei sixth in reported pneumoconiosis cases nationwide. Objective To analyze 76 years of pneumoconiosis data (1949–2024) in Hebei Province to provide evidence-based support for prevention and control strategies. Methods Occupational pneumoconiosis cases diagnosed in Hebei from 1949 to 2024 were included. Five-year intervals were used to analyze incidence composition, dust exposure duration, age at first diagnosis, and age at death. A hybrid model, integrating autoregressive integrated moving average (ARIMA) with generalized regression neural network (GRNN), was employed to predict case numbers for the 2025−2030 period. Results A total of 36107 cases of pneumoconiosis were recorded (2.10% female) in Hebei from 1949 to 2024. Stages I, II, and III accounted for 77.35%, 16.45%, and 6.20%, respectively. Silicosis (55.60%), coal workers’ pneumoconiosis (27.24%), and pottery workers’ pneumoconiosis (8.88%) were the predominant types. Observed trends included a shortened dust exposure duration [silicosis: (12.78±7.063) years in 2020–2024] and an increasing age at first diagnosis [(54.01±7.499) years in 2020–2024]. The case-fatality rate was 14.84%, with a rising age at death [(82.26±9.632) years in 2015–2019]. Three incidence peaks (1963, 1984, and 2014) correlated with national policies and industrialization phases. The number of pneumoconiosis cases showed a decreasing trend from 2015 to 2024. Chengde and Tangshan were identified as current high-risk areas. The ARIMA-GRNN model projected annual cases between 416 and 429 during 2025–2030. Conclusion In the past decade，the number of pneumoconiosis cases in Hebei Province had shown a decreasing trend, it is projected to plateau with no significant decline over the next five years. Furthermore, challenges such as the proportion of silicosis remaining high and shortened dust exposure duration remain severe. It is recommended to focus on key regions like Chengde (ore mining) and Tangshan (ceramics industry). A comprehensive strategy integrating stricter regulation, technological controls, model innovation, and targeted interventions should be implemented to achieve a further substantial reduction in pneumoconiosis incidence.

In order to promote the development of hair transplantation, particularly the establishment of standards, the Hair Transplantation Expert Group of Plastic and Aesthetic National Medical Quality Control Center invited experts in the field of hair transplantation across China and formed a draft of the Expert Consensus on Standard Terminology for Hair Transplantation based on the collation of relevant literature and monographs. By combining Delphi methodology and consensus meetings, the expert group conducted several rounds of consultations on issues such as follicular unit anatomy, harvesting, dissection, and implantation, ultimately presenting 54 terminologies. This consensus considers the original Chinese and English meanings as well as the professional characteristics of terms used in hair transplantation, highlights the unique features and advantages of hair transplantation, and preserves its essence while promoting innovation, with the hope of providing valuable reference for clinical researchers engaged in hair transplantation both domestically and internationally, and better facilitating the standardization and advancement of the field.

In order to promote the development of hair transplantation, particularly the establishment of standards, the Hair Transplantation Expert Group of Plastic and Aesthetic National Medical Quality Control Center invited experts in the field of hair transplantation across China and formed a draft of the Expert Consensus on Standard Terminology for Hair Transplantation based on the collation of relevant literature and monographs. By combining Delphi methodology and consensus meetings, the expert group conducted several rounds of consultations on issues such as follicular unit anatomy, harvesting, dissection, and implantation, ultimately presenting 54 terminologies. This consensus considers the original Chinese and English meanings as well as the professional characteristics of terms used in hair transplantation, highlights the unique features and advantages of hair transplantation, and preserves its essence while promoting innovation, with the hope of providing valuable reference for clinical researchers engaged in hair transplantation both domestically and internationally, and better facilitating the standardization and advancement of the field.

Objective: To explore the effects of different concentrations of glucose solution on the survival of Aedes albopictus and Culex pipiens pallens larvae, the attraction to mosquitoes and egg-laying behaviors, so as to provide the reference for developing mosquito control technology based on sugar bait. Methods: White porcelain bowls were filled with 100 mL of 3%, 5%, 8%, 10% and 15% glucose solutions. Ten of fourth instar larvae of Aedes albopictus or Culex pipiens pallens were added to each bowl, and the survival of larvae was recorded after 2, 4, 6, 24, 48 and 72 hours. Egg-laying cups containing 5%, 8% and 15% glucose solution were put in mosquito cages containing fully blooded female mosquitoes of Aedes albopictus and Culex pipiens pallens (50 mosquitoes each), and the total number of eggs laid in 72 hours was observed. The analogous site room was filled with fully blooded and starved female mosquitoes of Aedes albopictus and Culex pipiens pallens (100 mosquitoes each), and simple mosquito control buckets containing 5% and 8% glucose solution and black sticky insect plates. The number of mosquitoes and eggs was observed after 6 days. All the above experiments were repeated 3 times using dechlorinated water as the control. Results: The 72 hour corrected mortality rates of Aedes albopictus and Culex pipiens pallens larvae gradually increased with the increase of glucose concentration. The glucose solution with 5% and higher concentrations was not suitable for mosquito larvae to survive. The attraction of egg-laying behaviors to Aedes albopictus and Culex pipiens pallens gradually decreased with the increase of glucose concentration. The effects were similar between 5% and 8% glucose solution, with the averages of 686.67 and 682.33 eggs for Aedes albopictus, and 3.00 and 2.33 egg rafts for Culex pipiens pallens. In analogous site room, there were 93.33, 105.00 and 130.33 adult mosquitoes captured on average in the control group, 5% and 8% glucose solution groups, respectively, with 8% glucose solution group more attractive to adult mosquitoes than the control group (F=3.283, P=0.030); there were 70.33, 55.33 and 63.00 Aedes albopictus eggs (eggs counts+larvae counts) on average, respectively, with statistically significant differences among the three groups (H=6.761, P=0.034). Conclusion Glucose solution with concentration of 5% or higher can effectively inhibit the survival of Aedes albopictus and Culex pipiens pallens larvae, and attractive to adult mosquitoes and egg-laying behavoirs.

Objective: To investigate whether grain-sized moxibustion at Xinshu (BL15) and Shenshu (BL23) can alleviate cognitive decline and other pathologic features in early-stage Alzheimer disease (AD) using transgenic mice with 5 familial AD mutations (5XFAD). Methods: The genotype of transgenic mice was detected by polymerase chain reaction. A total of 40 transgenic mice (1.5 months old) were randomly and equally allocated to an AD model group (5XFAD group) or a grain-sized moxibustion group (5XFAD + GM group), with 20 wild-type (WT) mice (C57BL/6J) serving as the normal control group (WT group). Mice in the 5XFAD + GM group were treated by grain-sized moxibustion at bilateral Xinshu (BL15) and Shenshu (BL23). Mice in the WT group and 5XFAD group received no treatment but were restrained to ensure exposure to a similar experimental condition. Cognitive function and memory were assessed with the Morris water maze and Y-maze tests. The amyloid β 40 (Aβ40) and amyloid β 42 (Aβ42) levels in the brain were evaluated by enzyme-linked immunosorbent assay; amyloid plaque deposition in brain tissue sections was detected by thioflavin-S staining; the expression of glial fibrillary acidic protein (GFAP), cluster of differentiation 11b (CD11b), brain-derived neurotrophic factor (BDNF), and choline acetyltransferase (ChAT) in the hippocampus and prefrontal cortex was analyzed by immunohistochemistry. Results: In the Morris water maze test, compared with the 5XFAD group, mice in the 5XFAD + GM group had a shorter escape latency and more target area crossings and spent more time in the target quadrant (P<0.05). In the Y-maze test, compared with the 5XFAD group, the number of training times of the 5XFAD + GM group was significantly decreased (P<0.05), together with more correct responses (P<0.05). Compared with the 5XFAD group, the levels of Aβ40 and Aβ42 in the brain tissue of the 5XFAD + GM group were significantly lower (P<0.05); in the hippocampus and prefrontal cortex, the total number of amyloid β plaque deposition were significantly lower (P<0.05); the expression levels of GFAP and CD11b were significantly reduced (P<0.05); and the expression levels of ChAT and BDNF were significantly increased (P<0.05).Conclusion: Grain-sized moxibustion at Xinshu (BL15) and Shenshu (BL23) greatly improves learning and memory functions, decreases the levels of Aβ40 and Aβ42, inhibits amyloid β plaque deposition, decreases the expression of GFAP and CD11b, and increases the expression of ChAT and BDNF in AD mice to inhibit the progression of AD.

Objective: To investigate the origin of infection and risk factors of a case with SARS-CoV-2 infection associated with overseas countries in the Ningbo-Zhoushan Port, Zhejiang Province, so as to provide the evidence for improving the COVID-19 control measures at ports. Methods: Ningbo Center for Disease Control and Prevention ( CDC ) and Beilun CDC conducted case finding and epidemiological surveys immediately after being informed. The general information, history of vaccination and the travel during the latest 14 days were collected from the positive case, and all close contacts were tracked. Saliva samples were collected for SARS-CoV-2 nucleic acid testing and whole-genome sequencing, and the sequencing results were aligned with the GISAID's EpiCoV database. The origin of infection and transmission route of the positive case was investigated. Results: A case was identified positive for SARS-CoV-2 nucleic acid during company M's routine screening in the Ningbo-Zhoushan Port on August 10, 2021, and was confirmed positive for SARS-CoV-2 nucleic acid by Beilun CDC and Ningbo CDC on August 11. Whole-genome sequencing showed SARS-CoV-2 B.1.617.2 ( Delta ) variant, which shared the highest homology with the virus sequence uploaded by Russia on June, 2021 ( Russia/MOW-RII-MH27356S/2021 ). The case was a bundling worker for overseas container ships, and reported communicated with foreign boatmen and contacted materials without protected interventions on the SINOKOR AKITA Container Ship between August 4 and 5, 2021. This ship anchored at Vladivostok, Russia from July 27 to 29, anchored at Ningbo Harbor on August 4, and departed on August 5. Then, 11 boatmen from this ship were tested positive for SARS-CoV-2 nucleic acid on August 8. One asymptomatic case was reported in this epidemic; 254 close contacts and 617 secondary close contacts were identified, and all were tested negative for SARS-CoV-2 nucleic acid. No new cases with SARS-CoV-2 infections were detected until August 25, 2021, and the emergency response was therefore terminated. Conclusions The infection was a sporadic COVID-19 epidemic associated with overseas countries, which was caused by Delta variant infection through contacts with foreign boatmen or materials by a bundling worker in Ningbo-Zhoushan Port; fortunately, no epidemic spread occurred. Intensified closed-loop management and increased frequency of SARS-CoV-2 nucleic acid test among high-risk populations, and improving the precision and rapid emergency treatment of COVID-19 epidemics are required for the containment of COVID-19 at ports.

Objective:To explore the perioperative factors which influence the occurrence of prolonged postoperative ileus (PPOI) in patients with Crohn′s disease (CD) .Methods:A retrospective case-control study was conducted. Clinical data of CD patients who underwent partial intestinal resection at Jinling Hospital of Medical School of Nanjing University from June 2019 to January 2021 were analyzed retrospectively. The patients were divided into PPOI group and non-PPOI group according to whether the PPOI happened or not. The differences in perioperative indexes between PPOI and non-PPOI groups were assessed by univariate analysis. Spearman rank correlation test was used to exclude variables with strong correlations. The receiver operating characteristic (ROC) curve was performed to determine the cut-off values of the variables with P<0.05 in univariate analysis and clinical significance, and the variables were converted into binary qualitative data. And then the data were analyzed by multivariate Logistic regression to determine the independent risk factors of PPOI. Results:A total of 314 patients were included, including 202 males and 112 females with the age of (39 ± 14) years old. Eighty-nine (28.3%) patients with PPOI were set as PPOI group, and 225 (71.7%) patients without PPOI were set as non-PPOI group. Compared with non-PPOI group, patients in PPOI group had longer surgery duration [128 (99, 166) min vs. 110 (85, 141) min, P = 0.006], more total opioids [2.9 (2.4, 3.3) MME/kg vs. 2.7 (2.4, 3.1) MME/kg, P = 0.011, MME: morphine milligram equivalent], more intraoperative infusion volume ( P = 0.009), more crystal solution volume ( P = 0.007), higher intraoperative in-out balance per body weight (IOB/BW) [18.8 (14.1, 25.5) ml/kg vs. 16.4 (12.5, 20.7) ml/kg, P = 0.005], lower minimum level of albumin within 3 days after surgery ( P = 0.019), higher maximum change of albumin level after surgery ( P = 0.024), lower minimum concentration of serum potassium within 3 days after surgery ( P = 0.007), and more infusion supplement on the first day after surgery ( P<0.001), and longer postoperative hospital stay ( P<0.001). In the correlation analysis, there were strong correlations between intraoperative infusion volume and IOB/BW ( r = 0.689, P<0.001), and intraoperative infusion volume and crystal fluid volume ( r = 0.986, P<0.001) respectively. Therefore, intraoperative infusion volume and crystal fluid volume were excluded from the multivariate analysis. The cut-off value of the surgery duration was 123.5 min by ROC curve, the total opioids was 2.84 MME/kg, IOB/BW was 21.08 ml/kg, the minimum level of albumin and the minimum concentration of serum potassium within 3 days after surgery were 29.15 g/L and 3.75 mmol/L respectively, the maximum change of albumin level after surgery was 7.25 g/L, and the fluid supplement on the first day after surgery was 2751.5 ml. In multivariate Logistic regression analysis, surgery duration ≥ 123.5 min ( OR = 2.162, 95% CI: 1.260-3.710, P = 0.005), IOB/BW≥21.08 ml/kg ( OR = 3.184, 95% CI: 1.817-5.581, P<0.001), maximum change of albumin level ≥7.25 g/L after surgery ( OR = 1.948, 95% CI: 1.110-3.419, P = 0.02) and fluid supplement ≥2751.5 ml on the first day after surgery ( OR = 2.845, 95% CI: 1.630-4.966, P<0.001) were the independent risk factors for PPOI. Conclusions:CD patients who have the factors of long surgery duration, high IOB/BW, big change of albumin level after surgery and much fluid supplement on the first day after surgery are prone to PPOI. Therefore, controlling IOB/BW and fluid supplement on the first day after surgery are important measures to reduce the incidence of PPOI.

Objective:To analyze the feasibility and clinical efficacy of reperfusion-expanding-thrombectomy-stenting (RETS) technique in the endovascular treatment of acute carotid artery tandem lesion.Methods:The general clinical data of 88 patients with carotid artery tandem lesion who received emergency endovascular treatment from January 2018 to December 2020 in Department of Neurology, Linyi People′s Hospital were reviewed, the Modified Rankin Scale (mRS) was used as the evaluation standard for the prognosis of patients at 90 days after endovascular treatment, and the clinical data were analyzed, including the recanalization (modified thrombolysis in cerebral infarction ≥2b), perioperative complications and 90-day prognosis, and good prognosis was defined as a mRS score of 0-2.Results:A total of 88 patients with tandem carotid artery disease were included,48 of whom were treated with RETS technique, 40 were treated with anterograde approach. Compared with antegrade recanalization, RETS technique had significant differences in the time from puncture to recanalization [(72.06±17.29) min vs (98.88±26.09) min, t=-5.56, P<0.001] and the primary recanalization rate [35/48(73.0%) vs 21/40(52.5%),χ2=3.93 ,P=0.047], with statistically significant difference. There was no significant difference in clinical prognosis and surgical complications between the two methods (all P>0.05). Conclusions:RETS technique can shorten the operation time and increase the primary recanalization rate. RETS technique is safe and feasible for the treatment of carotid tandem lesions.

Objective:To explore the perioperative factors which influence the occurrence of prolonged postoperative ileus (PPOI) in patients with Crohn′s disease (CD) .Methods:A retrospective case-control study was conducted. Clinical data of CD patients who underwent partial intestinal resection at Jinling Hospital of Medical School of Nanjing University from June 2019 to January 2021 were analyzed retrospectively. The patients were divided into PPOI group and non-PPOI group according to whether the PPOI happened or not. The differences in perioperative indexes between PPOI and non-PPOI groups were assessed by univariate analysis. Spearman rank correlation test was used to exclude variables with strong correlations. The receiver operating characteristic (ROC) curve was performed to determine the cut-off values of the variables with P<0.05 in univariate analysis and clinical significance, and the variables were converted into binary qualitative data. And then the data were analyzed by multivariate Logistic regression to determine the independent risk factors of PPOI. Results:A total of 314 patients were included, including 202 males and 112 females with the age of (39 ± 14) years old. Eighty-nine (28.3%) patients with PPOI were set as PPOI group, and 225 (71.7%) patients without PPOI were set as non-PPOI group. Compared with non-PPOI group, patients in PPOI group had longer surgery duration [128 (99, 166) min vs. 110 (85, 141) min, P = 0.006], more total opioids [2.9 (2.4, 3.3) MME/kg vs. 2.7 (2.4, 3.1) MME/kg, P = 0.011, MME: morphine milligram equivalent], more intraoperative infusion volume ( P = 0.009), more crystal solution volume ( P = 0.007), higher intraoperative in-out balance per body weight (IOB/BW) [18.8 (14.1, 25.5) ml/kg vs. 16.4 (12.5, 20.7) ml/kg, P = 0.005], lower minimum level of albumin within 3 days after surgery ( P = 0.019), higher maximum change of albumin level after surgery ( P = 0.024), lower minimum concentration of serum potassium within 3 days after surgery ( P = 0.007), and more infusion supplement on the first day after surgery ( P<0.001), and longer postoperative hospital stay ( P<0.001). In the correlation analysis, there were strong correlations between intraoperative infusion volume and IOB/BW ( r = 0.689, P<0.001), and intraoperative infusion volume and crystal fluid volume ( r = 0.986, P<0.001) respectively. Therefore, intraoperative infusion volume and crystal fluid volume were excluded from the multivariate analysis. The cut-off value of the surgery duration was 123.5 min by ROC curve, the total opioids was 2.84 MME/kg, IOB/BW was 21.08 ml/kg, the minimum level of albumin and the minimum concentration of serum potassium within 3 days after surgery were 29.15 g/L and 3.75 mmol/L respectively, the maximum change of albumin level after surgery was 7.25 g/L, and the fluid supplement on the first day after surgery was 2751.5 ml. In multivariate Logistic regression analysis, surgery duration ≥ 123.5 min ( OR = 2.162, 95% CI: 1.260-3.710, P = 0.005), IOB/BW≥21.08 ml/kg ( OR = 3.184, 95% CI: 1.817-5.581, P<0.001), maximum change of albumin level ≥7.25 g/L after surgery ( OR = 1.948, 95% CI: 1.110-3.419, P = 0.02) and fluid supplement ≥2751.5 ml on the first day after surgery ( OR = 2.845, 95% CI: 1.630-4.966, P<0.001) were the independent risk factors for PPOI. Conclusions:CD patients who have the factors of long surgery duration, high IOB/BW, big change of albumin level after surgery and much fluid supplement on the first day after surgery are prone to PPOI. Therefore, controlling IOB/BW and fluid supplement on the first day after surgery are important measures to reduce the incidence of PPOI.