Objective:To compare the efficacy of saline irrigation following mesh basket lithotripsy and mesh basket combined with balloon lithotripsy for choledocholithiasis.Methods:Data of 76 patients who received endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis in Henan Provincial People's Hospital from May 2021 to May 2023 were retrospectively analyzed. Among them, 30 patients underwent saline irrigation of the biliary tract after mesh basket lithotripsy (the saline group), while 46 patients underwent mesh basket combined with balloon lithotripsy (the balloon group). The procedure success rate, operation time, procedure cost, and incidence of postoperative complications were compared.Results:The stone extraction success rates were 100.0% in both groups. The operation time in the saline group was shorter than that in the balloon group [20.0 (16.0, 27.5) min VS 29.0 (22.0, 33.3) min, Z=-2.88 , P=0.004]. The procedure cost in the saline group was lower than that in the balloon group [13 466.5 (13 318.0, 13 784.0) yuan VS 16 209.0 (15 989.0, 16 327.8) yuan, Z=-6.37 , P<0.001]. There was no significant difference in the incidence of postoperative fever, cholangitis or pancreatitis between the two groups ( P>0.05). Conclusion:Compared with mesh basket combined with balloon lithotripsy, saline irrigation of the biliary tract after mesh basket lithotripsy can shorten the operation time, reduce the procedure cost, and maintain a high procedure success rate for treating choledocholithiasis.

Objective:To investigate the association between dietary diversity and the risk of major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) .Methods:A total of 553 patients diagnosed with CHD and undergoing PCI in the Department of Cardiology at the Second Affiliated Hospital of Harbin Medical University between May and November 2023 were enrolled using a convenience sampling method. A Semi-Quantitative Food Frequency Questionnaire was used to assess patients' dietary intake after PCI, and the Dietary Diversity Score (DDS) was calculated. Patients were followed up for one year to determine the incidence of MACE.Results:History of hypertension, history of hyperlipidemia, body mass index, use of antiplatelet agents, use of diuretics, triglycerides, smoking index and DDS were identified as factors influencing the occurrence of MACE after PCI ( P<0.05) . Among these, higher dietary diversity had a protective effect against MACE. Conclusions:After PCI, patients with lower DDS experienced MACE more frequently than those with higher scores. Increased dietary diversity can effectively help prevent MACE in patients after PCI.

Objective:To explore the current dietary patterns and influencing factors of patients with coronary heart disease (CHD) in severe cold regions, aiming to provide scientific evidence for developing targeted dietary interventions.Methods:A total of 340 patients with CHD who visited the Department of Cardiology at the Second Affiliated Hospital of Harbin Medical University between September and December 2023 were selected using convenience sampling. Patients were assessed using a general information questionnaire, Semi-Quantitative Food Frequency Questionnaire, Food Choice Questionnaire, Nutritional Knowledge Questionnaire, 7-Item Generalized Anxiety Disorder Scale, and Patient Health Questionnaire-9.Results:A total of 340 questionnaires were distributed, and 333 valid questionnaires were collected, with an effective response rate of 97.94% (333/340). Two dietary patterns were identified among patients with CHD in severe cold regions: a "fruit-nut-dairy" dietary pattern and a "meat-seafood-grain" dietary pattern. Factors influencing the "fruit-nut-dairy" dietary pattern included gender, nutritional knowledge, and food choice motivations such as accessibility, sensory appeal, brand and packaging, and emotional dimensions ( P<0.05). Factors influencing the "meat-seafood-grain" dietary pattern included body mass index (BMI), living alone or not, monthly income, and food choice motivations such as convenience, health attributes, sensory appeal, and price ( P<0.05) . Conclusions:When providing dietary interventions for CHD patients, targeted control of factors such as gender, BMI, living alone or not, monthly income, nutritional knowledge, and key elements of food choice motivations may optimize patients' irrational dietary structures and reduce adverse disease outcomes.

[Purpose]To analyze the trends of incidence and mortality of lung cancer in Jinshan District of Shanghai from 2002 to 2020.[Methods]The data of lung cancer was obtained from the Shanghai Cancer Registry and the population data was obtained from the Jinshan District Bureau of Public Security.The crude rate and age-standardized rate of incidence and mortality(ASIR and ASMR),and the average annual percentage change(AAPC)of lung cancer were calculated.[Results]From 2002 to 2020,8 982 new cases and 6 081 deaths of lung cancer were reported.The ASIR of lung cancer increased from 36.55/105 to 56.72/105 with an AAPC of 3.34％(P＜0.05).The ASIR was also increased in male and female,with higher increase in female(AAPC=8.56％)than that in male(AAPC=0.50％).The ASMR decreased from 32.25/105 to 23.06/105 with an AAPC of-2.08％(P＜0.05).The ASMR was decreased both in male and female,with higher decline in male(AAPC=-2.71％)than that in female(AAPC=-0.43％).The disease risk in male was higher than that in female,while the difference in ASIR between male and female was decreasing.The inci-dence and mortality increased with age.[Conclusion]From 2002 to 2020,the incidence of lung cancer in Jinshan District was increasing,but the age-standardized mortality was decreasing.The incidence and mortality of lung cancer varied among different ages and sexes,so targeted preven-tion and control measures should be implemented.

Objective:To investigate the association between dietary diversity and the risk of major adverse cardiovascular events (MACE) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD) .Methods:A total of 553 patients diagnosed with CHD and undergoing PCI in the Department of Cardiology at the Second Affiliated Hospital of Harbin Medical University between May and November 2023 were enrolled using a convenience sampling method. A Semi-Quantitative Food Frequency Questionnaire was used to assess patients' dietary intake after PCI, and the Dietary Diversity Score (DDS) was calculated. Patients were followed up for one year to determine the incidence of MACE.Results:History of hypertension, history of hyperlipidemia, body mass index, use of antiplatelet agents, use of diuretics, triglycerides, smoking index and DDS were identified as factors influencing the occurrence of MACE after PCI ( P<0.05) . Among these, higher dietary diversity had a protective effect against MACE. Conclusions:After PCI, patients with lower DDS experienced MACE more frequently than those with higher scores. Increased dietary diversity can effectively help prevent MACE in patients after PCI.

Objective:To explore the current dietary patterns and influencing factors of patients with coronary heart disease (CHD) in severe cold regions, aiming to provide scientific evidence for developing targeted dietary interventions.Methods:A total of 340 patients with CHD who visited the Department of Cardiology at the Second Affiliated Hospital of Harbin Medical University between September and December 2023 were selected using convenience sampling. Patients were assessed using a general information questionnaire, Semi-Quantitative Food Frequency Questionnaire, Food Choice Questionnaire, Nutritional Knowledge Questionnaire, 7-Item Generalized Anxiety Disorder Scale, and Patient Health Questionnaire-9.Results:A total of 340 questionnaires were distributed, and 333 valid questionnaires were collected, with an effective response rate of 97.94% (333/340). Two dietary patterns were identified among patients with CHD in severe cold regions: a "fruit-nut-dairy" dietary pattern and a "meat-seafood-grain" dietary pattern. Factors influencing the "fruit-nut-dairy" dietary pattern included gender, nutritional knowledge, and food choice motivations such as accessibility, sensory appeal, brand and packaging, and emotional dimensions ( P<0.05). Factors influencing the "meat-seafood-grain" dietary pattern included body mass index (BMI), living alone or not, monthly income, and food choice motivations such as convenience, health attributes, sensory appeal, and price ( P<0.05) . Conclusions:When providing dietary interventions for CHD patients, targeted control of factors such as gender, BMI, living alone or not, monthly income, nutritional knowledge, and key elements of food choice motivations may optimize patients' irrational dietary structures and reduce adverse disease outcomes.

[Purpose]To analyze the trends of incidence and mortality of lung cancer in Jinshan District of Shanghai from 2002 to 2020.[Methods]The data of lung cancer was obtained from the Shanghai Cancer Registry and the population data was obtained from the Jinshan District Bureau of Public Security.The crude rate and age-standardized rate of incidence and mortality(ASIR and ASMR),and the average annual percentage change(AAPC)of lung cancer were calculated.[Results]From 2002 to 2020,8 982 new cases and 6 081 deaths of lung cancer were reported.The ASIR of lung cancer increased from 36.55/105 to 56.72/105 with an AAPC of 3.34％(P＜0.05).The ASIR was also increased in male and female,with higher increase in female(AAPC=8.56％)than that in male(AAPC=0.50％).The ASMR decreased from 32.25/105 to 23.06/105 with an AAPC of-2.08％(P＜0.05).The ASMR was decreased both in male and female,with higher decline in male(AAPC=-2.71％)than that in female(AAPC=-0.43％).The disease risk in male was higher than that in female,while the difference in ASIR between male and female was decreasing.The inci-dence and mortality increased with age.[Conclusion]From 2002 to 2020,the incidence of lung cancer in Jinshan District was increasing,but the age-standardized mortality was decreasing.The incidence and mortality of lung cancer varied among different ages and sexes,so targeted preven-tion and control measures should be implemented.

Objective:To compare the efficacy of saline irrigation following mesh basket lithotripsy and mesh basket combined with balloon lithotripsy for choledocholithiasis.Methods:Data of 76 patients who received endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis in Henan Provincial People's Hospital from May 2021 to May 2023 were retrospectively analyzed. Among them, 30 patients underwent saline irrigation of the biliary tract after mesh basket lithotripsy (the saline group), while 46 patients underwent mesh basket combined with balloon lithotripsy (the balloon group). The procedure success rate, operation time, procedure cost, and incidence of postoperative complications were compared.Results:The stone extraction success rates were 100.0% in both groups. The operation time in the saline group was shorter than that in the balloon group [20.0 (16.0, 27.5) min VS 29.0 (22.0, 33.3) min, Z=-2.88 , P=0.004]. The procedure cost in the saline group was lower than that in the balloon group [13 466.5 (13 318.0, 13 784.0) yuan VS 16 209.0 (15 989.0, 16 327.8) yuan, Z=-6.37 , P<0.001]. There was no significant difference in the incidence of postoperative fever, cholangitis or pancreatitis between the two groups ( P>0.05). Conclusion:Compared with mesh basket combined with balloon lithotripsy, saline irrigation of the biliary tract after mesh basket lithotripsy can shorten the operation time, reduce the procedure cost, and maintain a high procedure success rate for treating choledocholithiasis.

With the postponement of human reproductive time, studying how to intervene in reproductive system aging has become a globally significant topic. Sirtuins are NAD +-dependent histone deacetylases that play key roles in gene regulation, apoptosis, energy metabolism, age-related diseases, and the reproductive system. Current evidence suggests that deletion of the Sirtuins gene leads to developmental disorders and reproductive aging in both males and females, and that pharmacological intervention in Sirtuins expression can affect aging-induced decline in reproductive function. This review provides a comprehensive review of the effects and mechanisms of Sirtuins on male and female reproductive aging, and lists some natural drugs that can modulate Sirtuins activity, providing ideas for further studies on the regulation of reproductive aging at the molecular level.

With the postponement of human reproductive time, studying how to intervene in reproductive system aging has become a globally significant topic. Sirtuins are NAD +-dependent histone deacetylases that play key roles in gene regulation, apoptosis, energy metabolism, age-related diseases, and the reproductive system. Current evidence suggests that deletion of the Sirtuins gene leads to developmental disorders and reproductive aging in both males and females, and that pharmacological intervention in Sirtuins expression can affect aging-induced decline in reproductive function. This review provides a comprehensive review of the effects and mechanisms of Sirtuins on male and female reproductive aging, and lists some natural drugs that can modulate Sirtuins activity, providing ideas for further studies on the regulation of reproductive aging at the molecular level.