Objective:To analyze the key influencing factors of cognitive function of patients with moderate and severe traumatic brain injury (TBI).Methods:The clinical data of 113 patients with moderate and severe TBI admitted to the Department of Rehabilitation Medicine of the Affiliated Hospital of Nantong University from January 1st, 2012 to December 31st, 2018 were retrospectively reviewed to analyze the factors affecting cognitive function in patients with moderate and severe TBI by using the Mini-Mental State Examination (MMSE) to evaluate the cognitive function of patients at discharge.Results:The average age of 113 patients was 52.42±14.20 years old, among whom 74.34% were male and 64.6% of the male patients were injured due to traffic accidents. In the univariate analysis, a total of 8 variables related with MMSE at discharge, including age, history of hypertension, Glasgow coma scale (GCS) at admission, abnormal pupillary reflex at admission, tracheotomy, days of coma, hyperbaric oxygen therapy, and hydrocephalus during hospitalization, with statistically significant differences ( P<0.05). Multivariate analysis showed that GCS score at admission, hyperbaric oxygen therapy, days of coma, and age were the independent factors affecting MMSE at discharge, and the differences were statistically significant ( P<0.05). Conclusion:GCS score at admission, days of coma, and age can be adopted independently to determine the cognitive function of patients with moderate and severe TBI. Hydrocephalus during hospitalization, history of hypertension, abnormal pupillary reflex at admission, and tracheotomy can be used synthetically to determine the cognitive function. Hyperbaric oxygen therapy can improve the cognitive function.

Objective:To analyze the key influencing factors of cognitive function of patients with moderate and severe traumatic brain injury (TBI).Methods:The clinical data of 113 patients with moderate and severe TBI admitted to the Department of Rehabilitation Medicine of the Affiliated Hospital of Nantong University from January 1st, 2012 to December 31st, 2018 were retrospectively reviewed to analyze the factors affecting cognitive function in patients with moderate and severe TBI by using the Mini-Mental State Examination (MMSE) to evaluate the cognitive function of patients at discharge.Results:The average age of 113 patients was 52.42±14.20 years old, among whom 74.34% were male and 64.6% of the male patients were injured due to traffic accidents. In the univariate analysis, a total of 8 variables related with MMSE at discharge, including age, history of hypertension, Glasgow coma scale (GCS) at admission, abnormal pupillary reflex at admission, tracheotomy, days of coma, hyperbaric oxygen therapy, and hydrocephalus during hospitalization, with statistically significant differences ( P<0.05). Multivariate analysis showed that GCS score at admission, hyperbaric oxygen therapy, days of coma, and age were the independent factors affecting MMSE at discharge, and the differences were statistically significant ( P<0.05). Conclusion:GCS score at admission, days of coma, and age can be adopted independently to determine the cognitive function of patients with moderate and severe TBI. Hydrocephalus during hospitalization, history of hypertension, abnormal pupillary reflex at admission, and tracheotomy can be used synthetically to determine the cognitive function. Hyperbaric oxygen therapy can improve the cognitive function.