1.Association of atopic dermatitis with ankylosing spondylitis:A two-sample Mendelian randomized study
Mingjing WEI ; Zhengchao SHAO ; Haoyue WAN ; Yiheng WANG ; Wenqi CHEN
Chinese Journal of Immunology 2025;41(5):1055-1059
Objective:To investigate whether there is a causal relationship between atopic dermatitis(AD)and ankylosing spondylitis(AS).Methods:Genetic data of AD and AS were extracted from genome-wide association studies(GWAS)by Mendelian randomization(MR),and inverse variance-weighted(IVW)analysis was used as main analysis,supplemented by weighted median,MR-Egger,weighted mode,etc,and verified by a series of sensitivity analyses.Results:IVW analysis of AD by AS:OR=1.015,95％CI:1.005～1.025,P=0.004.IVW analysis of AD for AS:OR=1.001,95％CI:1.000～1.002,P=0.120.Conclusion:AS has a statisti-cally small causal relationship on AD,and AD has no causal effect on AS.
2.Association of atopic dermatitis with ankylosing spondylitis:A two-sample Mendelian randomized study
Mingjing WEI ; Zhengchao SHAO ; Haoyue WAN ; Yiheng WANG ; Wenqi CHEN
Chinese Journal of Immunology 2025;41(5):1055-1059
Objective:To investigate whether there is a causal relationship between atopic dermatitis(AD)and ankylosing spondylitis(AS).Methods:Genetic data of AD and AS were extracted from genome-wide association studies(GWAS)by Mendelian randomization(MR),and inverse variance-weighted(IVW)analysis was used as main analysis,supplemented by weighted median,MR-Egger,weighted mode,etc,and verified by a series of sensitivity analyses.Results:IVW analysis of AD by AS:OR=1.015,95％CI:1.005～1.025,P=0.004.IVW analysis of AD for AS:OR=1.001,95％CI:1.000～1.002,P=0.120.Conclusion:AS has a statisti-cally small causal relationship on AD,and AD has no causal effect on AS.
Result Analysis
Print
Save
E-mail