Objective To investigate the infection distribution of the hospital-acquired pneumonia (HAP) in patients with Staphylococcus aureus (S.aureus) and its drug resistance to those commonly-used antimicrobial agents, so as to provide evidence for rational use of antibacterial drugs clinically .Methods Retrospective analysis of the infection status and drug resistance of Staphylococ-cus aureus in 336 cases of HAP treated in the hospital from January 2011 to December 2015 was made in the study .Results (1) Nine-ty-three strains of Staphylococcus aureus were isolated from the 336 cases of HAP (27.7%), including 78 strains of methicillin-resist-ant Staphylococcus aureus (MRSA), accounting for 83.9%.(2) The infection rates of Staphylococcus aureus for the HAP patients in the five years were respectively 29.6%, 26.7%, 26.9%, 25.3%and 30.1%.There were no statistical differences in infection rates , when comparisons were made between the years (P>0.05).(3) Bacterial resistance analysis indicated that the patients with HAP-MRSA infection were completely sensitive to vancomycin and linezolid ( by 100%) , fairly sensitive to compound sulfamethoxazole and rifampicin ( by about 70%) and other antibiotics , such as beta lactams , macrolides and fluoroquinolones , was poorly sensitive ( by as low as less than 30%).Conclusion In HAP patients, Staphylococcus aureus was the main Gram positive pathogen , with MRSA infec-tion being the main case .Vancomycin and linezolid should be the first choice of drugs in clinical application of antibiotics for the treat -ment of HAP-MRSA infection.

Asian Continental Ancestry Group ; Hearing Loss ; genetics ; Humans ; Mutation ; genetics ; Pedigree ; RNA, Ribosomal ; genetics